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Items: 1 to 20 of 202


Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1.

Broz P, Ruby T, Belhocine K, Bouley DM, Kayagaki N, Dixit VM, Monack DM.

Nature. 2012 Oct 11;490(7419):288-91. doi: 10.1038/nature11419.


Non-canonical inflammasome activation targets caspase-11.

Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, Newton K, Qu Y, Liu J, Heldens S, Zhang J, Lee WP, Roose-Girma M, Dixit VM.

Nature. 2011 Oct 16;479(7371):117-21. doi: 10.1038/nature10558.


Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1β Production upon Extrinsic Stimulation in Culture.

Cieniewicz B, Dong Q, Li G, Forrest JC, Mounce BC, Tarakanova VL, van der Velden A, Krug LT.

J Virol. 2015 Jul;89(13):6562-74. doi: 10.1128/JVI.00658-15.


Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production.

Man SM, Tourlomousis P, Hopkins L, Monie TP, Fitzgerald KA, Bryant CE.

J Immunol. 2013 Nov 15;191(10):5239-46. doi: 10.4049/jimmunol.1301581.


Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar typhimurium infection, but not for the initiation of bacterial clearance.

Talbot S, Tötemeyer S, Yamamoto M, Akira S, Hughes K, Gray D, Barr T, Mastroeni P, Maskell DJ, Bryant CE.

Immunology. 2009 Dec;128(4):472-83. doi: 10.1111/j.1365-2567.2009.03146.x.


Salmonella Suppresses the TRIF-Dependent Type I Interferon Response in Macrophages.

Owen KA, Anderson CJ, Casanova JE.

MBio. 2016 Feb 16;7(1):e02051-15. doi: 10.1128/mBio.02051-15.


Evolution of inflammasome functions in vertebrates: Inflammasome and caspase-1 trigger fish macrophage cell death but are dispensable for the processing of IL-1β.

Angosto D, López-Castejón G, López-Muñoz A, Sepulcre MP, Arizcun M, Meseguer J, Mulero V.

Innate Immun. 2012 Dec;18(6):815-24. doi: 10.1177/1753425912441956.


Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.

Pilla DM, Hagar JA, Haldar AK, Mason AK, Degrandi D, Pfeffer K, Ernst RK, Yamamoto M, Miao EA, Coers J.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6046-51. doi: 10.1073/pnas.1321700111.


Caspase-11 protects against bacteria that escape the vacuole.

Aachoui Y, Leaf IA, Hagar JA, Fontana MF, Campos CG, Zak DE, Tan MH, Cotter PA, Vance RE, Aderem A, Miao EA.

Science. 2013 Feb 22;339(6122):975-8. doi: 10.1126/science.1230751.


Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens.

Casson CN, Yu J, Reyes VM, Taschuk FO, Yadav A, Copenhaver AM, Nguyen HT, Collman RG, Shin S.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):6688-93. doi: 10.1073/pnas.1421699112.


Mechanisms and pathways of innate immune activation and regulation in health and cancer.

Cui J, Chen Y, Wang HY, Wang RF.

Hum Vaccin Immunother. 2014;10(11):3270-85. doi: 10.4161/21645515.2014.979640. Review.


Activation of P2X(7) receptor by ATP plays an important role in regulating inflammatory responses during acute viral infection.

Lee BH, Hwang DM, Palaniyar N, Grinstein S, Philpott DJ, Hu J.

PLoS One. 2012;7(4):e35812. doi: 10.1371/journal.pone.0035812.


Pyroptotic cell death defends against intracellular pathogens.

Jorgensen I, Miao EA.

Immunol Rev. 2015 May;265(1):130-42. doi: 10.1111/imr.12287. Review.


Salmonella Typhimurium Co-Opts the Host Type I IFN System To Restrict Macrophage Innate Immune Transcriptional Responses Selectively.

Perkins DJ, Rajaiah R, Tennant SM, Ramachandran G, Higginson EE, Dyson TN, Vogel SN.

J Immunol. 2015 Sep 1;195(5):2461-71. doi: 10.4049/jimmunol.1500105.


Actin polymerization as a key innate immune effector mechanism to control Salmonella infection.

Man SM, Ekpenyong A, Tourlomousis P, Achouri S, Cammarota E, Hughes K, Rizzo A, Ng G, Wright JA, Cicuta P, Guck JR, Bryant CE.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17588-93. doi: 10.1073/pnas.1419925111.


Salmonella downregulates Nod-like receptor family CARD domain containing protein 4 expression to promote its survival in B cells by preventing inflammasome activation and cell death.

Perez-Lopez A, Rosales-Reyes R, Alpuche-Aranda CM, Ortiz-Navarrete V.

J Immunol. 2013 Feb 1;190(3):1201-9. doi: 10.4049/jimmunol.1200415.


Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity.

Yang J, Zhao Y, Shao F.

Curr Opin Immunol. 2015 Feb;32:78-83. doi: 10.1016/j.coi.2015.01.007. Review.


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