Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 102

1.

Synthesis of stable isotope labelled internal standards for drug-drug interaction (DDI) studies.

Atzrodt J, Blankenstein J, Brasseur D, Calvo-Vicente S, Denoux M, Derdau V, Lavisse M, Perard S, Roy S, Sandvoss M, Schofield J, Zimmermann J.

Bioorg Med Chem. 2012 Sep 15;20(18):5658-67. doi: 10.1016/j.bmc.2012.06.052. Epub 2012 Jul 20.

PMID:
22890009
2.

Microwave-assisted deuterium exchange: the convenient preparation of isotopically labelled analogues for stable isotope dilution analysis of volatile wine phenols.

Crump AM, Sefton MA, Wilkinson KL.

Food Chem. 2014 Nov 1;162:261-3. doi: 10.1016/j.foodchem.2014.04.051. Epub 2014 Apr 24.

PMID:
24874385
3.

Preparation of labeled human drug metabolites and drug-drug interaction-probes with fungal peroxygenases.

Poraj-Kobielska M, Atzrodt J, Holla W, Sandvoss M, Gröbe G, Scheibner K, Hofrichter M.

J Labelled Comp Radiopharm. 2013 Jul-Aug;56(9-10):513-9. doi: 10.1002/jlcr.3103. Epub 2013 Aug 29.

PMID:
24285530
4.

Preparative synthesis of drug metabolites using human cytochrome P450s 3A4, 2C9 and 1A2 with NADPH-P450 reductase expressed in Escherichia coli.

Vail RB, Homann MJ, Hanna I, Zaks A.

J Ind Microbiol Biotechnol. 2005 Feb;32(2):67-74. Epub 2005 Mar 1.

PMID:
15739102
5.

Liquid chromatography/tandem mass spectrometry method for simultaneous evaluation of activities of five cytochrome P450s using a five-drug cocktail and application to cytochrome P450 phenotyping studies in rats.

Zhang S, Song N, Li Q, Fan H, Liu C.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Aug 1;871(1):78-89. doi: 10.1016/j.jchromb.2008.06.034. Epub 2008 Jun 27.

PMID:
18614408
6.

Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat.

Kobayashi K, Urashima K, Shimada N, Chiba K.

Biochem Pharmacol. 2002 Mar 1;63(5):889-96.

PMID:
11911841
7.

High-resolution isotope-dilution mass spectrometry using metabolism of isotope-labeled compounds: application to drug metabolites.

Vrbanac JJ, Hilgers A, Dubnicka T, Shilliday FB, Humphries D, Hayes RN.

Rapid Commun Mass Spectrom. 2012 Nov 30;26(22):2569-76. doi: 10.1002/rcm.6376.

PMID:
23059872
8.

Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites.

Damsten MC, van Vugt-Lussenburg BM, Zeldenthuis T, de Vlieger JS, Commandeur JN, Vermeulen NP.

Chem Biol Interact. 2008 Jan 10;171(1):96-107. Epub 2007 Oct 5.

PMID:
17996858
10.

Experiments for a systematic comparison between stable-isotope-(deuterium) labeling and radio-((14)C) labeling for the elucidation of the in vitro metabolic pattern of pharmaceutical drugs.

Grunwald H, Hargreaves P, Gebhardt K, Klauer D, Serafyn A, Schmitt-Hoffmann A, Schleimer M, Schlotterbeck G, Wind M.

J Pharm Biomed Anal. 2013 Nov;85:138-44. doi: 10.1016/j.jpba.2013.07.004. Epub 2013 Jul 19.

PMID:
23933567
11.

Regional distribution of drug-metabolizing enzyme activities in the liver and small intestine of cynomolgus monkeys.

Nakanishi Y, Matsushita A, Matsuno K, Iwasaki K, Utoh M, Nakamura C, Uno Y.

Drug Metab Pharmacokinet. 2011 Jun;26(3):288-94. doi: 10.2133/dmpk.DMPK-10-NT-101. Epub 2011 Jan 25.

12.

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

Gorski JC, Hall SD, Jones DR, VandenBranden M, Wrighton SA.

Biochem Pharmacol. 1994 Apr 29;47(9):1643-53.

PMID:
8185679
13.

Microbial production of phase I and phase II metabolites of midazolam.

Marvalin C, Denoux M, Pérard S, Roy S, Azerad R.

Xenobiotica. 2012 Mar;42(3):285-93. doi: 10.3109/00498254.2011.622417. Epub 2011 Oct 24.

PMID:
22022919
14.

First evidence for occurrence of hydroxylated human metabolites of diclofenac and aceclofenac in wastewater using QqLIT-MS and QqTOF-MS.

Pérez S, Barceló D.

Anal Chem. 2008 Nov 1;80(21):8135-45. doi: 10.1021/ac801167w. Epub 2008 Sep 26.

PMID:
18821734
15.

Synthesis of deuterium-labelled fluorobenzoic acids to be used as internal standards in isotope dilution mass spectrometry.

Müller K, Seubert A.

Isotopes Environ Health Stud. 2014;50(1):88-93. doi: 10.1080/10256016.2013.830612. Epub 2014 Feb 5.

PMID:
24499142
16.

Drug interactions of diclofenac and its oxidative metabolite with human liver microsomal cytochrome P450 1A2-dependent drug oxidation.

Ohyama K, Murayama N, Shimizu M, Yamazaki H.

Xenobiotica. 2014 Jan;44(1):10-6. doi: 10.3109/00498254.2013.806837. Epub 2013 Jun 18.

PMID:
23777257
17.

A sensitive and specific CYP cocktail assay for the simultaneous assessment of human cytochrome P450 activities in primary cultures of human hepatocytes using LC-MS/MS.

Pillai VC, Strom SC, Caritis SN, Venkataramanan R.

J Pharm Biomed Anal. 2013 Feb 23;74:126-32. doi: 10.1016/j.jpba.2012.10.016. Epub 2012 Oct 22.

18.

A UPLC-MS/MS assay of the "Pittsburgh cocktail": six CYP probe-drug/metabolites from human plasma and urine using stable isotope dilution.

Stewart NA, Buch SC, Conrads TP, Branch RA.

Analyst. 2011 Feb 7;136(3):605-12. doi: 10.1039/c0an00643b. Epub 2010 Nov 25.

19.

An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point.

Youdim KA, Lyons R, Payne L, Jones BC, Saunders K.

J Pharm Biomed Anal. 2008 Sep 10;48(1):92-9. doi: 10.1016/j.jpba.2008.05.011. Epub 2008 May 17.

PMID:
18584988

Supplemental Content

Support Center