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Items: 1 to 20 of 91

1.

Amino acid catabolism: a pivotal regulator of innate and adaptive immunity.

McGaha TL, Huang L, Lemos H, Metz R, Mautino M, Prendergast GC, Mellor AL.

Immunol Rev. 2012 Sep;249(1):135-57. doi: 10.1111/j.1600-065X.2012.01149.x. Review.

2.

Control of immune response by amino acid metabolism.

Grohmann U, Bronte V.

Immunol Rev. 2010 Jul;236:243-64. doi: 10.1111/j.1600-065X.2010.00915.x. Review.

PMID:
20636821
3.

Indoleamine 2,3 dioxygenase and metabolic control of immune responses.

Munn DH, Mellor AL.

Trends Immunol. 2013 Mar;34(3):137-43. doi: 10.1016/j.it.2012.10.001. Epub 2012 Oct 25. Review.

4.

Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells.

Eleftheriadis T, Pissas G, Antoniadi G, Liakopoulos V, Stefanidis I.

Immunology. 2015 Oct;146(2):292-300. doi: 10.1111/imm.12502. Epub 2015 Jul 27.

5.

Inhibition of indoleamine 2,3-dioxygenase in mixed lymphocyte reaction affects glucose influx and enzymes involved in aerobic glycolysis and glutaminolysis in alloreactive T-cells.

Eleftheriadis T, Pissas G, Yiannaki E, Markala D, Arampatzis S, Antoniadi G, Liakopoulos V, Stefanidis I.

Hum Immunol. 2013 Dec;74(12):1501-9. doi: 10.1016/j.humimm.2013.08.268. Epub 2013 Aug 28.

PMID:
23993986
6.

Amino acid auxotrophy as a system of immunological control nodes.

Murray PJ.

Nat Immunol. 2016 Feb;17(2):132-9. doi: 10.1038/ni.3323. Review.

7.

Metabolic control of tumour progression and antitumour immunity.

Huang L, Mellor AL.

Curr Opin Oncol. 2014 Jan;26(1):92-9. doi: 10.1097/CCO.0000000000000035. Review.

8.

Molecules in focus: indoleamine 2,3-dioxygenase.

King NJ, Thomas SR.

Int J Biochem Cell Biol. 2007;39(12):2167-72. Epub 2007 Jan 20. Review.

PMID:
17320464
9.

Tryptophan catabolism and T cell responses.

Mellor AL, Munn D, Chandler P, Keskin D, Johnson T, Marshall B, Jhaver K, Baban B.

Adv Exp Med Biol. 2003;527:27-35. Review.

PMID:
15206713
10.

Indoleamine 2,3-dioxygenase and dendritic cell tolerogenicity.

Harden JL, Egilmez NK.

Immunol Invest. 2012;41(6-7):738-64. doi: 10.3109/08820139.2012.676122. Review.

11.

Indoleamine 2,3 dioxygenase and regulation of T cell immunity.

Mellor A.

Biochem Biophys Res Commun. 2005 Dec 9;338(1):20-4. Epub 2005 Sep 8. Review.

PMID:
16157293
12.

IDO expression by dendritic cells: tolerance and tryptophan catabolism.

Mellor AL, Munn DH.

Nat Rev Immunol. 2004 Oct;4(10):762-74. Review.

PMID:
15459668
13.

Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation.

Eleftheriadis T, Pissas G, Antoniadi G, Spanoulis A, Liakopoulos V, Stefanidis I.

Int Immunol. 2014 Dec;26(12):673-84. doi: 10.1093/intimm/dxu077. Epub 2014 Jul 26.

PMID:
25064493
14.

Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer disease.

Macchiarulo A, Camaioni E, Nuti R, Pellicciari R.

Amino Acids. 2009 Jul;37(2):219-29. doi: 10.1007/s00726-008-0137-3. Epub 2008 Jul 9. Review.

PMID:
18612775
15.

TOR in the immune system.

Araki K, Ellebedy AH, Ahmed R.

Curr Opin Cell Biol. 2011 Dec;23(6):707-15. doi: 10.1016/j.ceb.2011.08.006. Epub 2011 Sep 16. Review.

16.

Clinical relevance of indoleamine 2,3-dioxygenase for alloimmunity and transplantation.

Brandacher G, Margreiter R, Fuchs D.

Curr Opin Organ Transplant. 2008 Feb;13(1):10-5. doi: 10.1097/MOT.0b013e3282f3df26. Review.

PMID:
18660700
17.

Amino acid deprivation links BLIMP-1 to the immunomodulatory enzyme indoleamine 2,3-dioxygenase.

Barnes NA, Stephenson SJ, Tooze RM, Doody GM.

J Immunol. 2009 Nov 1;183(9):5768-77. doi: 10.4049/jimmunol.0803480. Epub 2009 Oct 14.

18.

Efficient tryptophan-catabolizing activity is consistently conserved through evolution of TDO enzymes, but not IDO enzymes.

Yuasa HJ, Ball HJ.

J Exp Zool B Mol Dev Evol. 2015 Mar;324(2):128-40. doi: 10.1002/jez.b.22608. Epub 2015 Feb 20.

PMID:
25702628
19.

Tryptophan catabolism generates autoimmune-preventive regulatory T cells.

Fallarino F, Grohmann U, You S, McGrath BC, Cavener DR, Vacca C, Orabona C, Bianchi R, Belladonna ML, Volpi C, Fioretti MC, Puccetti P.

Transpl Immunol. 2006 Dec;17(1):58-60. Epub 2006 Oct 10.

PMID:
17157218
20.

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.

Ye J, Palm W, Peng M, King B, Lindsten T, Li MO, Koumenis C, Thompson CB.

Genes Dev. 2015 Nov 15;29(22):2331-6. doi: 10.1101/gad.269324.115. Epub 2015 Nov 5.

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