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Larix laricina, an Antidiabetic Alternative Treatment from the Cree of Northern Quebec Pharmacopoeia, Decreases Glycemia and Improves Insulin Sensitivity In Vivo.

Harbilas D, Vallerand D, Brault A, Saleem A, Arnason JT, Musallam L, Haddad PS.

Evid Based Complement Alternat Med. 2012;2012:296432. doi: 10.1155/2012/296432. Epub 2012 Jul 19.


Adipogenic constituents from the bark of Larix laricina du Roi (K. Koch; Pinaceae), an important medicinal plant used traditionally by the Cree of Eeyou Istchee (Quebec, Canada) for the treatment of type 2 diabetes symptoms.

Shang N, Guerrero-Analco JA, Musallam L, Saleem A, Muhammad A, Walshe-Roussel B, Cuerrier A, Arnason JT, Haddad PS.

J Ethnopharmacol. 2012 Jun 14;141(3):1051-7. doi: 10.1016/j.jep.2012.04.002. Epub 2012 Apr 19.


Populus balsamifera L. (Salicaceae) mitigates the development of obesity and improves insulin sensitivity in a diet-induced obese mouse model.

Harbilas D, Brault A, Vallerand D, Martineau LC, Saleem A, Arnason JT, Musallam L, Haddad PS.

J Ethnopharmacol. 2012 Jun 14;141(3):1012-20. doi: 10.1016/j.jep.2012.03.046. Epub 2012 Apr 4.


Populus balsamifera Extract and Its Active Component Salicortin Reduce Obesity and Attenuate Insulin Resistance in a Diet-Induced Obese Mouse Model.

Harbilas D, Vallerand D, Brault A, Saleem A, Arnason JT, Musallam L, Haddad PS.

Evid Based Complement Alternat Med. 2013;2013:172537. doi: 10.1155/2013/172537. Epub 2013 May 27.


Larix laricina bark, a traditional medicine used by the Cree of Eeyou Istchee: Antioxidant constituents and in vitro permeability across Caco-2 cell monolayers.

Yong Y, Saleem A, Guerrero-Analco JA, Haddad PS, Cuerrier A, Arnason JT, Harris CS, Johns T.

J Ethnopharmacol. 2016 Dec 24;194:651-657. doi: 10.1016/j.jep.2016.10.054. Epub 2016 Oct 21.


Rhododendron groenlandicum (Labrador tea), an antidiabetic plant from the traditional pharmacopoeia of the Canadian Eastern James Bay Cree, improves renal integrity in the diet-induced obese mouse model.

Li S, Brault A, Sanchez Villavicencio M, Haddad PS.

Pharm Biol. 2016 Oct;54(10):1998-2006. doi: 10.3109/13880209.2015.1137953. Epub 2016 Feb 26.


Lingonberry (Vaccinium vitis-idaea L.) Exhibits Antidiabetic Activities in a Mouse Model of Diet-Induced Obesity.

Eid HM, Ouchfoun M, Brault A, Vallerand D, Musallam L, Arnason JT, Haddad PS.

Evid Based Complement Alternat Med. 2014;2014:645812. doi: 10.1155/2014/645812. Epub 2014 Jun 10.


The action of antidiabetic plants of the canadian james bay cree traditional pharmacopeia on key enzymes of hepatic glucose homeostasis.

Nachar A, Vallerand D, Musallam L, Lavoie L, Badawi A, Arnason J, Haddad PS.

Evid Based Complement Alternat Med. 2013;2013:189819. doi: 10.1155/2013/189819. Epub 2013 Jun 24.


In Vivo Anti-Diabetic Activity of the Ethanolic Crude Extract of Sorbus decora C.K.Schneid. (Rosacea): A Medicinal Plant Used by Canadian James Bay Cree Nations to Treat Symptoms Related to Diabetes.

Vianna R, Brault A, Martineau LC, Couture R, Arnason JT, Haddad PS.

Evid Based Complement Alternat Med. 2011;2011:237941. doi: 10.1093/ecam/nep158. Epub 2011 Aug 11.


Labrador tea (Rhododendron groenlandicum) attenuates insulin resistance in a diet-induced obesity mouse model.

Ouchfoun M, Eid HM, Musallam L, Brault A, Li S, Vallerand D, Arnason JT, Haddad PS.

Eur J Nutr. 2016 Apr;55(3):941-54. doi: 10.1007/s00394-015-0908-z. Epub 2015 Apr 28.


Antidiabetic compounds from Sarracenia purpurea used traditionally by the Eeyou Istchee Cree First Nation.

Muhammad A, Guerrero-Analco JA, Martineau LC, Musallam L, Madiraju P, Nachar A, Saleem A, Haddad PS, Arnason JT.

J Nat Prod. 2012 Jul 27;75(7):1284-8. doi: 10.1021/np3001317. Epub 2012 Jun 27.


Plants used by the Cree Nation of Eeyou Istchee (Quebec, Canada) for the treatment of diabetes: A novel approach in quantitative ethnobotany.

Leduc C, Coonishish J, Haddad P, Cuerrier A.

J Ethnopharmacol. 2006 Apr 21;105(1-2):55-63. Epub 2005 Nov 16.


Adipogenic Activity of Wild Populations of Rhododendron groenlandicum, a Medicinal Shrub from the James Bay Cree Traditional Pharmacopeia.

Rapinski M, Musallam L, Arnason JT, Haddad P, Cuerrier A.

Evid Based Complement Alternat Med. 2015;2015:492458. doi: 10.1155/2015/492458. Epub 2015 Oct 5.


Stimulation of AMP-activated protein kinase and enhancement of basal glucose uptake in muscle cells by quercetin and quercetin glycosides, active principles of the antidiabetic medicinal plant Vaccinium vitis-idaea.

Eid HM, Martineau LC, Saleem A, Muhammad A, Vallerand D, Benhaddou-Andaloussi A, Nistor L, Afshar A, Arnason JT, Haddad PS.

Mol Nutr Food Res. 2010 Jul;54(7):991-1003. doi: 10.1002/mnfr.200900218.


Quality of diet is associated with insulin resistance in the Cree (Eeyouch) indigenous population of northern Qu├ębec.

Johnson-Down L, Labonte ME, Martin ID, Tsuji LJ, Nieboer E, Dewailly E, Egeland G, Lucas M.

Nutr Metab Cardiovasc Dis. 2015 Jan;25(1):85-92. doi: 10.1016/j.numecd.2014.08.002. Epub 2014 Aug 28.


Metformin reduces body weight gain and improves glucose intolerance in high-fat diet-fed C57BL/6J mice.

Matsui Y, Hirasawa Y, Sugiura T, Toyoshi T, Kyuki K, Ito M.

Biol Pharm Bull. 2010;33(6):963-70.


Utility of current obesity thresholds in signaling diabetes risk in the James Bay Cree of Eeyou Istchee.

Manjoo P, Dannenbaum D, Joseph L, Torrie J, Dasgupta K.

BMJ Open Diabetes Res Care. 2015 Aug 14;3(1):e000114. doi: 10.1136/bmjdrc-2015-000114. eCollection 2015.


Oral salmon calcitonin protects against impaired fasting glycemia, glucose intolerance, and obesity induced by high-fat diet and ovariectomy in rats.

Feigh M, Andreassen KV, Hjuler ST, Nielsen RH, Christiansen C, Henriksen K, Karsdal MA.

Menopause. 2013 Jul;20(7):785-94. doi: 10.1097/GME.0b013e31827c58ab.


Selected plant species from the Cree pharmacopoeia of northern Quebec possess anti-diabetic potential.

Spoor DC, Martineau LC, Leduc C, Benhaddou-Andaloussi A, Meddah B, Harris C, Burt A, Fraser MH, Coonishish J, Joly E, Cuerrier A, Bennett SA, Johns T, Prentki M, Arnason JT, Haddad PS.

Can J Physiol Pharmacol. 2006 Aug-Sep;84(8-9):847-58.


A combination of (+)-catechin and (-)-epicatechin underlies the in vitro adipogenic action of Labrador tea (Rhododendron groenlandicum), an antidiabetic medicinal plant of the Eastern James Bay Cree pharmacopeia.

Eid HM, Ouchfoun M, Saleem A, Guerrero-Analco JA, Walshe-Roussel B, Musallam L, Rapinski M, Cuerrier A, Martineau LC, Arnason JT, Haddad PS.

J Ethnopharmacol. 2016 Feb 3;178:251-7. doi: 10.1016/j.jep.2015.12.021. Epub 2015 Dec 18.


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