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Items: 1 to 20 of 214

1.

Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation.

Visweswaraiah J, Lee SJ, Hinnebusch AG, Sattlegger E.

J Biol Chem. 2012 Nov 2;287(45):37757-68. doi: 10.1074/jbc.M112.368266. Epub 2012 Aug 10.

2.

Gcn1 contacts the small ribosomal protein Rps10, which is required for full activation of the protein kinase Gcn2.

Lee SJ, Swanson MJ, Sattlegger E.

Biochem J. 2015 Mar 15;466(3):547-59. doi: 10.1042/BJ20140782.

PMID:
25437641
3.
4.

Evidence that GCN1 and GCN20, translational regulators of GCN4, function on elongating ribosomes in activation of eIF2alpha kinase GCN2.

Marton MJ, Vazquez de Aldana CR, Qiu H, Chakraburtty K, Hinnebusch AG.

Mol Cell Biol. 1997 Aug;17(8):4474-89.

5.

Evidence that Yih1 resides in a complex with ribosomes.

Waller T, Lee SJ, Sattlegger E.

FEBS J. 2012 May;279(10):1761-76. doi: 10.1111/j.1742-4658.2012.08553.x. Epub 2012 Apr 10.

6.

Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity.

Visweswaraiah J, Lageix S, Castilho BA, Izotova L, Kinzy TG, Hinnebusch AG, Sattlegger E.

J Biol Chem. 2011 Oct 21;286(42):36568-79. doi: 10.1074/jbc.M111.248898. Epub 2011 Aug 17.

8.

YIH1 is an actin-binding protein that inhibits protein kinase GCN2 and impairs general amino acid control when overexpressed.

Sattlegger E, Swanson MJ, Ashcraft EA, Jennings JL, Fekete RA, Link AJ, Hinnebusch AG.

J Biol Chem. 2004 Jul 16;279(29):29952-62. Epub 2004 May 4.

9.
11.

Budding yeast GCN1 binds the GI domain to activate the eIF2alpha kinase GCN2.

Kubota H, Ota K, Sakaki Y, Ito T.

J Biol Chem. 2001 May 18;276(20):17591-6. Epub 2001 Feb 28.

13.

Gcn1 and actin binding to Yih1: implications for activation of the eIF2 kinase GCN2.

Sattlegger E, Barbosa JA, Moraes MC, Martins RM, Hinnebusch AG, Castilho BA.

J Biol Chem. 2011 Mar 25;286(12):10341-55. doi: 10.1074/jbc.M110.171587. Epub 2011 Jan 14.

14.

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.

Ramirez M, Wek RC, Vazquez de Aldana CR, Jackson BM, Freeman B, Hinnebusch AG.

Mol Cell Biol. 1992 Dec;12(12):5801-15.

15.

Saccharomyces cerevisiae Rbg1 protein and its binding partner Gir2 interact on Polyribosomes with Gcn1.

Wout PK, Sattlegger E, Sullivan SM, Maddock JR.

Eukaryot Cell. 2009 Jul;8(7):1061-71. doi: 10.1128/EC.00356-08. Epub 2009 May 15.

16.

Mutations in the chromodomain-like insertion of translation elongation factor 3 compromise protein synthesis through reduced ATPase activity.

Sasikumar AN, Kinzy TG.

J Biol Chem. 2014 Feb 21;289(8):4853-60. doi: 10.1074/jbc.M113.536201. Epub 2013 Dec 30.

18.

Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo.

Lageix S, Zhang J, Rothenburg S, Hinnebusch AG.

PLoS Genet. 2015 Feb 19;11(2):e1004991. doi: 10.1371/journal.pgen.1004991. eCollection 2015 Feb.

19.

A network of hydrophobic residues impeding helix alphaC rotation maintains latency of kinase Gcn2, which phosphorylates the alpha subunit of translation initiation factor 2.

Gárriz A, Qiu H, Dey M, Seo EJ, Dever TE, Hinnebusch AG.

Mol Cell Biol. 2009 Mar;29(6):1592-607. doi: 10.1128/MCB.01446-08. Epub 2008 Dec 29.

20.

Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

Cambiaghi TD, Pereira CM, Shanmugam R, Bolech M, Wek RC, Sattlegger E, Castilho BA.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):592-7. doi: 10.1016/j.bbrc.2013.12.021. Epub 2013 Dec 11.

PMID:
24333428

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