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Items: 1 to 20 of 104

1.

TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.

Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grøfte M, Bartkova J, Poulsen M, Oka Y, Bekker-Jensen S, Mailand N, Neumann B, Heriche JK, Shearer R, Saunders D, Bartek J, Lukas J, Lukas C.

Cell. 2012 Aug 17;150(4):697-709. doi: 10.1016/j.cell.2012.06.039. Epub 2012 Aug 9. Erratum in: Cell. 2014 Dec 4;159(6):1476-7.

2.

Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks.

Poulsen M, Lukas C, Lukas J, Bekker-Jensen S, Mailand N.

J Cell Biol. 2012 Apr 16;197(2):189-99. doi: 10.1083/jcb.201109100. Epub 2012 Apr 9.

3.

RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins.

Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C.

Cell. 2009 Feb 6;136(3):435-46. doi: 10.1016/j.cell.2008.12.041.

4.

A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci.

Helchowski CM, Skow LF, Roberts KH, Chute CL, Canman CE.

Cell Cycle. 2013 Dec 15;12(24):3749-58. doi: 10.4161/cc.26640. Epub 2013 Oct 3.

5.

RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks.

Bohgaki M, Bohgaki T, El Ghamrasni S, Srikumar T, Maire G, Panier S, Fradet-Turcotte A, Stewart GS, Raught B, Hakem A, Hakem R.

Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):20982-7. doi: 10.1073/pnas.1320302111. Epub 2013 Dec 9.

6.

Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage.

Thorslund T, Ripplinger A, Hoffmann S, Wild T, Uckelmann M, Villumsen B, Narita T, Sixma TK, Choudhary C, Bekker-Jensen S, Mailand N.

Nature. 2015 Nov 19;527(7578):389-93. doi: 10.1038/nature15401. Epub 2015 Oct 21.

PMID:
26503038
7.

The deubiquitylating enzyme USP44 counteracts the DNA double-strand break response mediated by the RNF8 and RNF168 ubiquitin ligases.

Mosbech A, Lukas C, Bekker-Jensen S, Mailand N.

J Biol Chem. 2013 Jun 7;288(23):16579-87. doi: 10.1074/jbc.M113.459917. Epub 2013 Apr 24.

8.

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins.

Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J.

Cell. 2007 Nov 30;131(5):887-900. Epub 2007 Nov 20.

9.

Regulatory ubiquitylation in response to DNA double-strand breaks.

Panier S, Durocher D.

DNA Repair (Amst). 2009 Apr 5;8(4):436-43. doi: 10.1016/j.dnarep.2009.01.013. Epub 2009 Feb 18. Review.

PMID:
19230794
10.

The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.

Typas D, Luijsterburg MS, Wiegant WW, Diakatou M, Helfricht A, Thijssen PE, van den Broek B, Mullenders LH, van Attikum H.

Nucleic Acids Res. 2015 Aug 18;43(14):6919-33. doi: 10.1093/nar/gkv613. Epub 2015 Jun 22. Erratum in: Nucleic Acids Res. 2016 Apr 7;44(6):2976. van de Broek, Bram [Corrected to van den Broek, Bram].

11.

Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling.

Smeenk G, Wiegant WW, Marteijn JA, Luijsterburg MS, Sroczynski N, Costelloe T, Romeijn RJ, Pastink A, Mailand N, Vermeulen W, van Attikum H.

J Cell Sci. 2013 Feb 15;126(Pt 4):889-903. doi: 10.1242/jcs.109413. Epub 2012 Dec 21.

12.

Ubiquitin-H2AX fusions render 53BP1 recruitment to DNA damage sites independent of RNF8 or RNF168.

Kocyłowski MK, Rey AJ, Stewart GS, Halazonetis TD.

Cell Cycle. 2015;14(11):1748-58. doi: 10.1080/15384101.2015.1010918.

13.

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks.

Acs K, Luijsterburg MS, Ackermann L, Salomons FA, Hoppe T, Dantuma NP.

Nat Struct Mol Biol. 2011 Nov 27;18(12):1345-50. doi: 10.1038/nsmb.2188.

PMID:
22120668
14.

Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks.

Harding SM, Bristow RG.

Cell Cycle. 2012 Apr 1;11(7):1432-44. doi: 10.4161/cc.19824. Epub 2012 Apr 1.

PMID:
22421153
15.

The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks.

Bekker-Jensen S, Mailand N.

FEBS Lett. 2011 Sep 16;585(18):2914-9. doi: 10.1016/j.febslet.2011.05.056. Epub 2011 Jun 12. Review.

16.

RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage.

Ramaekers CH, van den Beucken T, Bristow RG, Chiu RK, Durocher D, Wouters BG.

PLoS One. 2014 Feb 28;9(2):e89997. doi: 10.1371/journal.pone.0089997. eCollection 2014.

17.

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.

Galanty Y, Belotserkovskaya R, Coates J, Polo S, Miller KM, Jackson SP.

Nature. 2009 Dec 17;462(7275):935-9. doi: 10.1038/nature08657.

18.

RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1.

Muñoz MC, Laulier C, Gunn A, Cheng A, Robbiani DF, Nussenzweig A, Stark JM.

J Biol Chem. 2012 Nov 23;287(48):40618-28. doi: 10.1074/jbc.M112.410951. Epub 2012 Oct 10.

19.

Crosstalk between histone modifications during the DNA damage response.

van Attikum H, Gasser SM.

Trends Cell Biol. 2009 May;19(5):207-17. doi: 10.1016/j.tcb.2009.03.001. Epub 2009 Apr 1. Review.

PMID:
19342239
20.

The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks.

Sy SM, Jiang J, O WS, Deng Y, Huen MS.

Nucleic Acids Res. 2013 Oct;41(18):8572-80. doi: 10.1093/nar/gkt622. Epub 2013 Jul 17.

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