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DEPTOR cell-autonomously promotes adipogenesis, and its expression is associated with obesity.

Laplante M, Horvat S, Festuccia WT, Birsoy K, Prevorsek Z, Efeyan A, Sabatini DM.

Cell Metab. 2012 Aug 8;16(2):202-12. doi: 10.1016/j.cmet.2012.07.008.


TGFβ-induced deptor suppression recruits mTORC1 and not mTORC2 to enhance collagen I (α2) gene expression.

Das F, Bera A, Ghosh-Choudhury N, Abboud HE, Kasinath BS, Choudhury GG.

PLoS One. 2014 Oct 15;9(10):e109608. doi: 10.1371/journal.pone.0109608. eCollection 2014.


Rapid mitogenic regulation of the mTORC1 inhibitor, DEPTOR, by phosphatidic acid.

Yoon MS, Rosenberger CL, Wu C, Truong N, Sweedler JV, Chen J.

Mol Cell. 2015 May 7;58(3):549-56. doi: 10.1016/j.molcel.2015.03.028. Epub 2015 Apr 30.


Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity.

Caron A, Labbé SM, Lanfray D, Blanchard PG, Villot R, Roy C, Sabatini DM, Richard D, Laplante M.

Mol Metab. 2015 Dec 8;5(2):102-12. doi: 10.1016/j.molmet.2015.11.005. eCollection 2016 Feb.


DEPTOR-mTOR Signaling Is Critical for Lipid Metabolism and Inflammation Homeostasis of Lymphocytes in Human PBMC Culture.

Xie QB, Liang Y, Yang M, Yang Y, Cen XM, Yin G.

J Immunol Res. 2017;2017:5252840. doi: 10.1155/2017/5252840. Epub 2017 Feb 27.


DEP domain-containing mTOR-interacting protein in the rat brain: distribution of expression and potential implication.

Caron A, Baraboi ED, Laplante M, Richard D.

J Comp Neurol. 2015 Jan 1;523(1):93-107. doi: 10.1002/cne.23668. Epub 2014 Sep 22.


Chemopreventive Effect of Dietary Glutamineon Colitis-Associated Colorectal Cancer Is Associated with Modulation of the DEPTOR/mTOR Signaling Pathway.

Tian Y, Wang K, Fan Y, Wang Y, Sun L, Wang L, Wang J, Wang Z, Li J, Ye Y, Ji G.

Nutrients. 2016 May 2;8(5). pii: E261. doi: 10.3390/nu8050261.


Elucidating the role of DEPTOR in Alzheimer's disease.

Davies J, Zachariades E, Rogers-Broadway KR, Karteris E.

Int J Mol Med. 2014 Nov;34(5):1195-200. doi: 10.3892/ijmm.2014.1895. Epub 2014 Aug 12.


Fisetin regulates obesity by targeting mTORC1 signaling.

Jung CH, Kim H, Ahn J, Jeon TI, Lee DH, Ha TY.

J Nutr Biochem. 2013 Aug;24(8):1547-54. doi: 10.1016/j.jnutbio.2013.01.003. Epub 2013 Mar 18.


Deptor knockdown enhances mTOR Activity and protein synthesis in myocytes and ameliorates disuse muscle atrophy.

Kazi AA, Hong-Brown L, Lang SM, Lang CH.

Mol Med. 2011 Sep-Oct;17(9-10):925-36. doi: 10.2119/molmed.2011.00070. Epub 2011 May 19.


The Baf60c/Deptor pathway links skeletal muscle inflammation to glucose homeostasis in obesity.

Meng ZX, Wang L, Xiao Y, Lin JD.

Diabetes. 2014 May;63(5):1533-45. doi: 10.2337/db13-1061. Epub 2014 Jan 23.


Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation.

Meng ZX, Li S, Wang L, Ko HJ, Lee Y, Jung DY, Okutsu M, Yan Z, Kim JK, Lin JD.

Nat Med. 2013 May;19(5):640-5. doi: 10.1038/nm.3144. Epub 2013 Apr 7.


Transcriptional response to aging and caloric restriction in heart and adipose tissue.

Linford NJ, Beyer RP, Gollahon K, Krajcik RA, Malloy VL, Demas V, Burmer GC, Rabinovitch PS.

Aging Cell. 2007 Oct;6(5):673-88.


p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation.

González-Terán B, López JA, Rodríguez E, Leiva L, Martínez-Martínez S, Bernal JA, Jiménez-Borreguero LJ, Redondo JM, Vazquez J, Sabio G.

Nat Commun. 2016 Jan 22;7:10477. doi: 10.1038/ncomms10477.


Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.

Liu M, Bai J, He S, Villarreal R, Hu D, Zhang C, Yang X, Liang H, Slaga TJ, Yu Y, Zhou Z, Blenis J, Scherer PE, Dong LQ, Liu F.

Cell Metab. 2014 Jun 3;19(6):967-80. doi: 10.1016/j.cmet.2014.03.018. Epub 2014 Apr 17.


Placental DEPTOR as a stress sensor during pregnancy.

Mparmpakas D, Zachariades E, Goumenou A, Gidron Y, Karteris E.

Clin Sci (Lond). 2012 Apr;122(7):349-59. doi: 10.1042/CS20110378.


DEPTOR-related mTOR suppression is involved in metformin's anti-cancer action in human liver cancer cells.

Obara A, Fujita Y, Abudukadier A, Fukushima T, Oguri Y, Ogura M, Harashima S, Hosokawa M, Inagaki N.

Biochem Biophys Res Commun. 2015 May 15;460(4):1047-52. doi: 10.1016/j.bbrc.2015.03.148. Epub 2015 Apr 3.


Functional characterization of glycine N-methyltransferase and its interactive protein DEPDC6/DEPTOR in hepatocellular carcinoma.

Yen CH, Lu YC, Li CH, Lee CM, Chen CY, Cheng MY, Huang SF, Chen KF, Cheng AL, Liao LY, Lee YH, Chen YM.

Mol Med. 2012 Mar 30;18:286-96. doi: 10.2119/molmed.2011.00331. Erratum in: Mol Med. 2012;18(1):546.


Ursolic acid inhibits leucine-stimulated mTORC1 signaling by suppressing mTOR localization to lysosome.

Ou X, Liu M, Luo H, Dong LQ, Liu F.

PLoS One. 2014 Apr 16;9(4):e95393. doi: 10.1371/journal.pone.0095393. eCollection 2014.


Androgen receptor functions as a negative transcriptional regulator of DEPTOR, mTOR inhibitor.

Kanno Y, Zhao S, Yamashita N, Yanai K, Nemoto K, Inouye Y.

J Toxicol Sci. 2015 Dec;40(6):753-8. doi: 10.2131/jts.40.753.

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