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Cell surface expression of human ether-a-go-go-related gene (hERG) channels is regulated by caveolin-3 protein via the ubiquitin ligase Nedd4-2.

Guo J, Wang T, Li X, Shallow H, Yang T, Li W, Xu J, Fridman MD, Yang X, Zhang S.

J Biol Chem. 2012 Sep 28;287(40):33132-41. Epub 2012 Aug 9.


Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips).

Kang Y, Guo J, Yang T, Li W, Zhang S.

Biochem J. 2015 Nov 15;472(1):71-82. doi: 10.1042/BJ20141282. Epub 2015 Sep 11.


The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11.

Lamothe SM, Zhang S.

J Biol Chem. 2013 May 24;288(21):15075-84. doi: 10.1074/jbc.M113.453670. Epub 2013 Apr 15.


Muscarinic receptor activation increases hERG channel expression through phosphorylation of ubiquitin ligase Nedd4-2.

Wang T, Hogan-Cann A, Kang Y, Cui Z, Guo J, Yang T, Lamothe SM, Li W, Ma A, Fisher JT, Zhang S.

Mol Pharmacol. 2014 Jun;85(6):877-86. doi: 10.1124/mol.113.091553. Epub 2014 Mar 31.


Involvement of caveolin in low K+-induced endocytic degradation of cell-surface human ether-a-go-go-related gene (hERG) channels.

Massaeli H, Sun T, Li X, Shallow H, Wu J, Xu J, Li W, Hanson C, Guo J, Zhang S.

J Biol Chem. 2010 Aug 27;285(35):27259-64. doi: 10.1074/jbc.M110.124909. Epub 2010 Jul 6.


Nedd4-2-dependent ubiquitylation and regulation of the cardiac potassium channel hERG1.

Albesa M, Grilo LS, Gavillet B, Abriel H.

J Mol Cell Cardiol. 2011 Jul;51(1):90-8. doi: 10.1016/j.yjmcc.2011.03.015. Epub 2011 Apr 2.


Mechanisms underlying probucol-induced hERG-channel deficiency.

Shi YQ, Yan CC, Zhang X, Yan M, Liu LR, Geng HZ, Lv L, Li BX.

Drug Des Devel Ther. 2015 Jul 20;9:3695-704. doi: 10.2147/DDDT.S86724. eCollection 2015.


Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes.

Guo J, Massaeli H, Li W, Xu J, Luo T, Shaw J, Kirshenbaum LA, Zhang S.

J Pharmacol Exp Ther. 2007 Jun;321(3):911-20. Epub 2007 Mar 21.


Rab11-dependent Recycling of the Human Ether-a-go-go-related Gene (hERG) Channel.

Chen J, Guo J, Yang T, Li W, Lamothe SM, Kang Y, Szendrey JA, Zhang S.

J Biol Chem. 2015 Aug 21;290(34):21101-13. doi: 10.1074/jbc.M115.636324. Epub 2015 Jul 7.


The role of monoubiquitination in endocytic degradation of human ether-a-go-go-related gene (hERG) channels under low K+ conditions.

Sun T, Guo J, Shallow H, Yang T, Xu J, Li W, Hanson C, Wu JG, Li X, Massaeli H, Zhang S.

J Biol Chem. 2011 Feb 25;286(8):6751-9. doi: 10.1074/jbc.M110.198408. Epub 2010 Dec 21.


Extracellular K+ is a prerequisite for the function and plasma membrane stability of HERG channels.

Massaeli H, Guo J, Xu J, Zhang S.

Circ Res. 2010 Apr 2;106(6):1072-82. doi: 10.1161/CIRCRESAHA.109.215970. Epub 2010 Feb 4.


Involvement of caveolin in probucol-induced reduction in hERG plasma-membrane expression.

Guo J, Li X, Shallow H, Xu J, Yang T, Massaeli H, Li W, Sun T, Pierce GN, Zhang S.

Mol Pharmacol. 2011 May;79(5):806-13. doi: 10.1124/mol.110.069419. Epub 2011 Jan 28.


Interaction between the cardiac rapidly (IKr) and slowly (IKs) activating delayed rectifier potassium channels revealed by low K+-induced hERG endocytic degradation.

Guo J, Wang T, Yang T, Xu J, Li W, Fridman MD, Fisher JT, Zhang S.

J Biol Chem. 2011 Oct 7;286(40):34664-74. doi: 10.1074/jbc.M111.253351. Epub 2011 Aug 15.


The regulation of the cardiac potassium channel (HERG) by caveolin-1.

Lin J, Lin S, Choy PC, Shen X, Deng C, Kuang S, Wu J, Xu W.

Biochem Cell Biol. 2008 Oct;86(5):405-15. doi: 10.1139/o08-118.


Ubiquitin ligase Nedd4-2 modulates Kv1.3 current amplitude and ion channel protein targeting.

VĂ©lez P, Schwartz AB, Iyer SR, Warrington A, Fadool DA.

J Neurophysiol. 2016 Aug 1;116(2):671-85. doi: 10.1152/jn.00874.2015. Epub 2016 May 4.


Hsp90 prevents interaction between CHIP and HERG proteins to facilitate maturation of wild-type and mutant HERG proteins.

Iwai C, Li P, Kurata Y, Hoshikawa Y, Morikawa K, Maharani N, Higaki K, Sasano T, Notsu T, Ishido Y, Miake J, Yamamoto Y, Shirayoshi Y, Ninomiya H, Nakai A, Murata S, Yoshida A, Yamamoto K, Hiraoka M, Hisatome I.

Cardiovasc Res. 2013 Dec 1;100(3):520-8. doi: 10.1093/cvr/cvt200. Epub 2013 Aug 20.


Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels.

Hantouche C, Williamson B, Valinsky WC, Solomon J, Shrier A, Young JC.

J Biol Chem. 2017 Feb 10;292(6):2287-2300. doi: 10.1074/jbc.M116.752618. Epub 2016 Dec 20.


The interaction of caveolin 3 protein with the potassium inward rectifier channel Kir2.1: physiology and pathology related to long qt syndrome 9 (LQT9).

Vaidyanathan R, Vega AL, Song C, Zhou Q, Tan BH, Berger S, Makielski JC, Eckhardt LL.

J Biol Chem. 2013 Jun 14;288(24):17472-80. doi: 10.1074/jbc.M112.435370. Epub 2013 May 2. Erratum in: J Biol Chem. 2013 Oct 4;288(40):28948. Tan, Bihua [corrected to Tan, Bi-Hua].


Progesterone impairs human ether-a-go-go-related gene (HERG) trafficking by disruption of intracellular cholesterol homeostasis.

Wu ZY, Yu DJ, Soong TW, Dawe GS, Bian JS.

J Biol Chem. 2011 Jun 24;286(25):22186-94. doi: 10.1074/jbc.M110.198853. Epub 2011 Apr 27.

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