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Late sodium current inhibition alone with ranolazine is sufficient to reduce ischemia- and cardiac glycoside-induced calcium overload and contractile dysfunction mediated by reverse-mode sodium/calcium exchange.

Soliman D, Wang L, Hamming KS, Yang W, Fatehi M, Carter CC, Clanachan AS, Light PE.

J Pharmacol Exp Ther. 2012 Nov;343(2):325-32. doi: 10.1124/jpet.112.196949. Epub 2012 Aug 9.


Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts.

Fraser H, Belardinelli L, Wang L, Light PE, McVeigh JJ, Clanachan AS.

J Mol Cell Cardiol. 2006 Dec;41(6):1031-8. Epub 2006 Oct 5.


Reducing the late sodium current improves cardiac function during sodium pump inhibition by ouabain.

Hoyer K, Song Y, Wang D, Phan D, Balschi J, Ingwall JS, Belardinelli L, Shryock JC.

J Pharmacol Exp Ther. 2011 May;337(2):513-23. doi: 10.1124/jpet.110.176776. Epub 2011 Feb 16.


Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat.

Aistrup GL, Gupta DK, Kelly JE, O'Toole MJ, Nahhas A, Chirayil N, Misener S, Beussink L, Singh N, Ng J, Reddy M, Mongkolrattanothai T, El-Bizri N, Rajamani S, Shryock JC, Belardinelli L, Shah SJ, Wasserstrom JA.

Am J Physiol Heart Circ Physiol. 2013 Oct 1;305(7):H1068-79. doi: 10.1152/ajpheart.00401.2013. Epub 2013 Jul 19.


Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice.

Burr AR, Millay DP, Goonasekera SA, Park KH, Sargent MA, Collins J, Altamirano F, Philipson KD, Allen PD, Ma J, López JR, Molkentin JD.

Mol Cell Biol. 2014 Jun;34(11):1991-2002. doi: 10.1128/MCB.00339-14. Epub 2014 Mar 24.


Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction.

Song Y, Shryock JC, Wagner S, Maier LS, Belardinelli L.

J Pharmacol Exp Ther. 2006 Jul;318(1):214-22. Epub 2006 Mar 24.


Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation.

Sossalla S, Wagner S, Rasenack EC, Ruff H, Weber SL, Schöndube FA, Tirilomis T, Tenderich G, Hasenfuss G, Belardinelli L, Maier LS.

J Mol Cell Cardiol. 2008 Jul;45(1):32-43. doi: 10.1016/j.yjmcc.2008.03.006. Epub 2008 Mar 14.


A novel mechanism for the treatment of angina, arrhythmias, and diastolic dysfunction: inhibition of late I(Na) using ranolazine.

Maier LS.

J Cardiovasc Pharmacol. 2009 Oct;54(4):279-86. doi: 10.1097/FJC.0b013e3181a1b9e7. Review.


The late Na+ current (INa) inhibitor ranolazine attenuates effects of palmitoyl-L-carnitine to increase late INa and cause ventricular diastolic dysfunction.

Wu Y, Song Y, Belardinelli L, Shryock JC.

J Pharmacol Exp Ther. 2009 Aug;330(2):550-7. doi: 10.1124/jpet.109.151936. Epub 2009 Apr 29.


Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action.

Beyder A, Strege PR, Reyes S, Bernard CE, Terzic A, Makielski J, Ackerman MJ, Farrugia G.

Circulation. 2012 Jun 5;125(22):2698-706. doi: 10.1161/CIRCULATIONAHA.112.094714. Epub 2012 May 7.


Induced overexpression of phospholemman S68E mutant improves cardiac contractility and mortality after ischemia-reperfusion.

Wang J, Song J, Gao E, Zhang XQ, Gu T, Yu D, Koch WJ, Feldman AM, Cheung JY.

Am J Physiol Heart Circ Physiol. 2014 Apr 1;306(7):H1066-77. doi: 10.1152/ajpheart.00861.2013. Epub 2014 Jan 31.


An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes.

Song Y, Shryock JC, Belardinelli L.

Am J Physiol Heart Circ Physiol. 2008 May;294(5):H2031-9. doi: 10.1152/ajpheart.01357.2007. Epub 2008 Feb 29.


Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties.

Antzelevitch C, Belardinelli L, Zygmunt AC, Burashnikov A, Di Diego JM, Fish JM, Cordeiro JM, Thomas G.

Circulation. 2004 Aug 24;110(8):904-10. Epub 2004 Aug 9.


Low extracellular K+ increases intracellular Ca2+ oscillation and injury by activating the reverse mode Na+-Ca2+ exchanger and inhibiting the Na+, K+ ATPase in rat cardiomyocytes.

Wu F, Wei GZ, Li WJ, Liu B, Zhou JJ, Wang HC, Gao F.

Int J Cardiol. 2010 Apr 15;140(2):161-8. doi: 10.1016/j.ijcard.2008.11.037. Epub 2008 Dec 6.


Ranolazine reduces Ca2+ overload and oxidative stress and improves mitochondrial integrity to protect against ischemia reperfusion injury in isolated hearts.

Aldakkak M, Camara AK, Heisner JS, Yang M, Stowe DF.

Pharmacol Res. 2011 Oct;64(4):381-92. doi: 10.1016/j.phrs.2011.06.018. Epub 2011 Jun 29.


Reactive oxygen species directly modify sodium-calcium exchanger activity in a splice variant-dependent manner.

Soliman D, Hamming KS, Matemisz LC, Light PE.

J Mol Cell Cardiol. 2009 Nov;47(5):595-602. doi: 10.1016/j.yjmcc.2009.05.011. Epub 2009 May 28.


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