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Items: 1 to 20 of 210

1.

Folate-PEG-appended dendrimer conjugate with α-cyclodextrin as a novel cancer cell-selective siRNA delivery carrier.

Arima H, Yoshimatsu A, Ikeda H, Ohyama A, Motoyama K, Higashi T, Tsuchiya A, Niidome T, Katayama Y, Hattori K, Takeuchi T.

Mol Pharm. 2012 Sep 4;9(9):2591-604. doi: 10.1021/mp300188f. Epub 2012 Aug 9.

PMID:
22873579
2.

Potential use of folate-polyethylene glycol (PEG)-appended dendrimer (G3) conjugate with α-cyclodextrin as DNA carriers to tumor cells.

Arima H, Arizono M, Higashi T, Yoshimatsu A, Ikeda H, Motoyama K, Hattori K, Takeuchi T, Hirayama F, Uekama K.

Cancer Gene Ther. 2012 May;19(5):358-66. doi: 10.1038/cgt.2012.9. Epub 2012 Mar 9.

PMID:
22402627
3.

In Vitro and In Vivo Tumor-Targeting siRNA Delivery Using Folate-PEG-appended Dendrimer (G4)/α-Cyclodextrin Conjugates.

Ohyama A, Higashi T, Motoyama K, Arima H.

Bioconjug Chem. 2016 Mar 16;27(3):521-32. doi: 10.1021/acs.bioconjchem.5b00545. Epub 2016 Jan 13.

PMID:
26715308
4.

Ternary complexes of folate-PEG-appended dendrimer (G4)/α-cyclodextrin conjugate, siRNA and low-molecular-weight polysaccharide sacran as a novel tumor-selective siRNA delivery system.

Ohyama A, Higashi T, Motoyama K, Arima H.

Int J Biol Macromol. 2017 Jun;99:21-28. doi: 10.1016/j.ijbiomac.2017.02.045. Epub 2017 Feb 14.

PMID:
28223132
5.

Design and evaluation of polyamidoamine dendrimer conjugate with PEG, α-cyclodextrin and lactose as a novel hepatocyte-selective gene carrier in vitro and in vivo.

Hayashi Y, Higashi T, Motoyama K, Mori Y, Jono H, Ando Y, Arima H.

J Drug Target. 2013 May;21(5):487-96. doi: 10.3109/1061186X.2013.769105. Epub 2013 Apr 9.

PMID:
23570609
6.

Recent Findings Concerning PAMAM Dendrimer Conjugates with Cyclodextrins as Carriers of DNA and RNA.

Arima H, Motoyama K.

Sensors (Basel). 2009;9(8):6346-61. doi: 10.3390/s90806346. Epub 2009 Aug 17.

7.

Sugar-appended polyamidoamine dendrimer conjugates with cyclodextrins as cell-specific non-viral vectors.

Arima H, Motoyama K, Higashi T.

Adv Drug Deliv Rev. 2013 Aug;65(9):1204-14. doi: 10.1016/j.addr.2013.04.001. Epub 2013 Apr 17. Review.

PMID:
23602906
8.

Inhibitory effect of siRNA complexes with polyamidoamine dendrimer/α-cyclodextrin conjugate (generation 3, G3) on endogenous gene expression.

Arima H, Tsutsumi T, Yoshimatsu A, Ikeda H, Motoyama K, Higashi T, Hirayama F, Uekama K.

Eur J Pharm Sci. 2011 Oct 9;44(3):375-84. doi: 10.1016/j.ejps.2011.08.019. Epub 2011 Aug 28.

PMID:
21896329
9.

Potential use of lactosylated dendrimer (G3)/α-cyclodextrin conjugates as hepatocyte-specific siRNA carriers for the treatment of familial amyloidotic polyneuropathy.

Hayashi Y, Mori Y, Yamashita S, Motoyama K, Higashi T, Jono H, Ando Y, Arima H.

Mol Pharm. 2012 Jun 4;9(6):1645-53. doi: 10.1021/mp200654g. Epub 2012 Apr 30.

PMID:
22510029
10.

Preparation and evaluation of polyamidoamine dendrimer conjugate with glucuronylglucosyl-β-cyclodextrin (G3) as a novel carrier for siRNA.

Abdelwahab AF, Ohyama A, Higashi T, Motoyama K, Khaled KA, Sarhan HA, Hussein AK, Arima H.

J Drug Target. 2014 Dec;22(10):927-34. doi: 10.3109/1061186X.2014.950663. Epub 2014 Aug 22.

PMID:
25148608
11.

Development of a targeted siRNA delivery system using FOL-PEG-PEI conjugate.

Biswal BK, Debata NB, Verma RS.

Mol Biol Rep. 2010 Jul;37(6):2919-26. doi: 10.1007/s11033-009-9853-3. Epub 2009 Oct 9.

PMID:
19816791
12.

Potential Use of Thioalkylated Mannose-Modified Dendrimer (G3)/α-Cyclodextrin Conjugate as an NF-κB siRNA Carrier for the Treatment of Fulminant Hepatitis.

Motoyama K, Mitsuyasu R, Akao C, Abu Hashim II, Sato N, Tanaka T, Higashi T, Arima H.

Mol Pharm. 2015 Sep 8;12(9):3129-36. doi: 10.1021/mp500814f. Epub 2015 Aug 20.

PMID:
26270769
13.

Evaluation of polyamidoamine dendrimer/alpha-cyclodextrin conjugate (generation 3, G3) as a novel carrier for small interfering RNA (siRNA).

Tsutsumi T, Hirayama F, Uekama K, Arima H.

J Control Release. 2007 Jun 22;119(3):349-59. Epub 2007 Mar 30.

PMID:
17477999
14.

In vitro and in vivo gene delivery mediated by Lactosylated dendrimer/alpha-cyclodextrin conjugates (G2) into hepatocytes.

Arima H, Yamashita S, Mori Y, Hayashi Y, Motoyama K, Hattori K, Takeuchi T, Jono H, Ando Y, Hirayama F, Uekama K.

J Control Release. 2010 Aug 17;146(1):106-17. doi: 10.1016/j.jconrel.2010.05.030. Epub 2010 May 31.

PMID:
20678990
15.

Polypseudorotaxanes of pegylated α-cyclodextrin/polyamidoamine dendrimer conjugate with cyclodextrins as a sustained release system for DNA.

Motoyama K, Hayashida K, Higashi T, Arima H.

Bioorg Med Chem. 2012 Feb 15;20(4):1425-33. doi: 10.1016/j.bmc.2011.12.060. Epub 2012 Jan 9.

PMID:
22277591
16.

Folate-appended β-cyclodextrin as a promising tumor targeting carrier for antitumor drugs in vitro and in vivo.

Okamatsu A, Motoyama K, Onodera R, Higashi T, Koshigoe T, Shimada Y, Hattori K, Takeuchi T, Arima H.

Bioconjug Chem. 2013 Apr 17;24(4):724-33. doi: 10.1021/bc400015r. Epub 2013 Mar 15.

PMID:
23458386
17.

Efficient and Tumor Targeted siRNA Delivery by Polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol)-folate (PEI-PCL-PEG-Fol).

Liu L, Zheng M, Librizzi D, Renette T, Merkel OM, Kissel T.

Mol Pharm. 2016 Jan 4;13(1):134-43. doi: 10.1021/acs.molpharmaceut.5b00575. Epub 2015 Dec 16.

PMID:
26641134
18.

Design and evaluation of folate-appended α-, β-, and γ-cyclodextrins having a caproic acid as a tumor selective antitumor drug carrier in vitro and in vivo.

Okamatsu A, Motoyama K, Onodera R, Higashi T, Koshigoe T, Shimada Y, Hattori K, Takeuchi T, Arima H.

Biomacromolecules. 2013 Dec 9;14(12):4420-8. doi: 10.1021/bm401340g. Epub 2013 Nov 21.

PMID:
24175976
19.

Cyclodextrin/Dendrimer conjugates as DNA and oligonucleotide carriers.

Arima H, Motoyama K, Higashi T.

Curr Top Med Chem. 2014;14(4):465-77. Review.

PMID:
24354672
20.

Design and evaluation of thioalkylated mannose-modified dendrimer (G3)/α-cyclodextrin conjugates as antigen-presenting cell-selective siRNA carriers.

Motoyama K, Mitsuyasu R, Akao C, Tanaka T, Ohyama A, Sato N, Higashi T, Arima H.

AAPS J. 2014 Nov;16(6):1298-308. doi: 10.1208/s12248-014-9665-9. Epub 2014 Sep 19.

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