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Items: 1 to 20 of 88

1.

Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase.

von Castelmur E, Strümpfer J, Franke B, Bogomolovas J, Barbieri S, Qadota H, Konarev PV, Svergun DI, Labeit S, Benian GM, Schulten K, Mayans O.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13608-13. doi: 10.1073/pnas.1200697109. Epub 2012 Aug 6.

2.

Single-molecule force spectroscopy reveals a stepwise unfolding of Caenorhabditis elegans giant protein kinase domains.

Greene DN, Garcia T, Sutton RB, Gernert KM, Benian GM, Oberhauser AF.

Biophys J. 2008 Aug;95(3):1360-70. doi: 10.1529/biophysj.108.130237. Epub 2008 Apr 4.

3.

Activation of calcium/calmodulin regulated kinases.

Wilmann M, Gautel M, Mayans O.

Cell Mol Biol (Noisy-le-grand). 2000 Jul;46(5):883-94.

PMID:
10976872
4.

Giant protein kinases: domain interactions and structural basis of autoregulation.

Kobe B, Heierhorst J, Feil SC, Parker MW, Benian GM, Weiss KR, Kemp BE.

EMBO J. 1996 Dec 16;15(24):6810-21.

5.

Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle.

Matsunaga Y, Qadota H, Furukawa M, Choe HH, Benian GM.

Mol Biol Cell. 2015 Jun 1;26(11):2096-111. doi: 10.1091/mbc.E14-05-1009. Epub 2015 Apr 7.

6.

Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line.

Bogomolovas J, Gasch A, Simkovic F, Rigden DJ, Labeit S, Mayans O.

Open Biol. 2014 May;4(5):140041. doi: 10.1098/rsob.140041.

7.

Insights into autoregulation from the crystal structure of twitchin kinase.

Hu SH, Parker MW, Lei JY, Wilce MC, Benian GM, Kemp BE.

Nature. 1994 Jun 16;369(6481):581-4.

PMID:
8202162
8.

Titins in C.elegans with unusual features: coiled-coil domains, novel regulation of kinase activity and two new possible elastic regions.

Flaherty DB, Gernert KM, Shmeleva N, Tang X, Mercer KB, Borodovsky M, Benian GM.

J Mol Biol. 2002 Oct 25;323(3):533-49.

PMID:
12381307
9.

Protein kinase domain of twitchin has protein kinase activity and an autoinhibitory region.

Lei J, Tang X, Chambers TC, Pohl J, Benian GM.

J Biol Chem. 1994 Aug 19;269(33):21078-85.

10.

Autophosphorylation of molluscan twitchin and interaction of its kinase domain with calcium/calmodulin.

Heierhorst J, Probst WC, Vilim FS, Buku A, Weiss KR.

J Biol Chem. 1994 Aug 19;269(33):21086-93.

11.

Targeting aurora2 kinase in oncogenesis: a structural bioinformatics approach to target validation and rational drug design.

Vankayalapati H, Bearss DJ, Saldanha JW, Muñoz RM, Rojanala S, Von Hoff DD, Mahadevan D.

Mol Cancer Ther. 2003 Mar;2(3):283-94.

12.

Substrate specificity and inhibitor sensitivity of Ca2+/S100-dependent twitchin kinases.

Heierhorst J, Tang X, Lei J, Probst WC, Weiss KR, Kemp BE, Benian GM.

Eur J Biochem. 1996 Dec 15;242(3):454-9.

13.

Ca2+/S100 regulation of giant protein kinases.

Heierhorst J, Kobe B, Feil SC, Parker MW, Benian GM, Weiss KR, Kemp BE.

Nature. 1996 Apr 18;380(6575):636-9.

PMID:
8602266
14.

Intrasteric regulation of calmodulin-dependent protein kinases.

Kemp BE, Barden JA, Kobe B, House C, Parker MW.

Adv Pharmacol. 1996;36:221-49. Review. No abstract available.

PMID:
8783562
15.

Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme.

Rosenberg OS, Deindl S, Sung RJ, Nairn AC, Kuriyan J.

Cell. 2005 Dec 2;123(5):849-60.

16.

Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans.

Fong S, Hamill SJ, Proctor M, Freund SM, Benian GM, Chothia C, Bycroft M, Clarke J.

J Mol Biol. 1996 Dec 6;264(3):624-39.

PMID:
8969309
17.

Cytoskeletal protein kinases: titin and its relations in mechanosensing.

Gautel M.

Pflugers Arch. 2011 Jul;462(1):119-34. doi: 10.1007/s00424-011-0946-1. Epub 2011 Mar 18. Review.

18.

Drosophila has a twitchin/titin-related gene that appears to encode projectin.

Ayme-Southgate A, Vigoreaux J, Benian G, Pardue ML.

Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):7973-7.

19.

Structural basis for activation of the titin kinase domain during myofibrillogenesis.

Mayans O, van der Ven PF, Wilm M, Mues A, Young P, Fürst DO, Wilmanns M, Gautel M.

Nature. 1998 Oct 29;395(6705):863-9. Erratum in: Nature 1999 Feb 25;397(6712):719.

PMID:
9804419
20.

Phosphorylation of myosin regulatory light chains by the molluscan twitchin kinase.

Heierhorst J, Probst WC, Kohanski RA, Buku A, Weiss KR.

Eur J Biochem. 1995 Oct 15;233(2):426-31.

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