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Items: 1 to 20 of 116

1.

β1 integrin NPXY motifs regulate kidney collecting-duct development and maintenance by induced-fit interactions with cytosolic proteins.

Mathew S, Lu Z, Palamuttam RJ, Mernaugh G, Hadziselimovic A, Chen J, Bulus N, Gewin LS, Voehler M, Meves A, Ballestrem C, Fässler R, Pozzi A, Sanders CR, Zent R.

Mol Cell Biol. 2012 Oct;32(20):4080-91. Epub 2012 Aug 6.

2.
3.

Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development.

Mathew S, Palamuttam RJ, Mernaugh G, Ramalingam H, Lu Z, Zhang MZ, Ishibe S, Critchley DR, Fässler R, Pozzi A, Sanders CR, Carroll TJ, Zent R.

Development. 2017 Nov 15;144(22):4148-4158. doi: 10.1242/dev.149914. Epub 2017 Oct 9.

PMID:
28993400
4.

β1 integrins with individually disrupted cytoplasmic NPxY motifs are embryonic lethal but partially active in the epidermis.

Meves A, Stremmel C, Böttcher RT, Fässler R.

J Invest Dermatol. 2013 Dec;133(12):2722-2731. doi: 10.1038/jid.2013.232. Epub 2013 May 23.

5.

Genetic analysis of beta1 integrin "activation motifs" in mice.

Czuchra A, Meyer H, Legate KR, Brakebusch C, Fässler R.

J Cell Biol. 2006 Sep 11;174(6):889-99. Epub 2006 Sep 5.

6.
7.

Integrin αII b tail distal of GFFKR participates in inside-out αII b β3 activation.

Li A, Guo Q, Kim C, Hu W, Ye F.

J Thromb Haemost. 2014 Jul;12(7):1145-55. doi: 10.1111/jth.12610. Epub 2014 Jun 25.

8.

Biophysical analysis of Kindlin-3 reveals an elongated conformation and maps integrin binding to the membrane-distal β-subunit NPXY motif.

Yates LA, Füzéry AK, Bonet R, Campbell ID, Gilbert RJ.

J Biol Chem. 2012 Nov 2;287(45):37715-31. doi: 10.1074/jbc.M112.415208. Epub 2012 Sep 18.

9.

Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation.

Bledzka K, Bialkowska K, Nie H, Qin J, Byzova T, Wu C, Plow EF, Ma YQ.

J Biol Chem. 2010 Oct 1;285(40):30370-4. doi: 10.1074/jbc.C110.134247. Epub 2010 Aug 11.

10.

The NPIY motif in the integrin beta1 tail dictates the requirement for talin-1 in outside-in signaling.

Nieves B, Jones CW, Ward R, Ohta Y, Reverte CG, LaFlamme SE.

J Cell Sci. 2010 Apr 15;123(Pt 8):1216-26. doi: 10.1242/jcs.056549. Epub 2010 Mar 23.

11.

Distinct roles of talin and kindlin in regulating integrin α5β1 function and trafficking.

Margadant C, Kreft M, de Groot DJ, Norman JC, Sonnenberg A.

Curr Biol. 2012 Sep 11;22(17):1554-63. doi: 10.1016/j.cub.2012.06.060. Epub 2012 Jul 12.

13.

Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation.

Anthis NJ, Haling JR, Oxley CL, Memo M, Wegener KL, Lim CJ, Ginsberg MH, Campbell ID.

J Biol Chem. 2009 Dec 25;284(52):36700-10. doi: 10.1074/jbc.M109.061275. Epub 2009 Oct 20.

14.

Structural determinants of integrin recognition by talin.

García-Alvarez B, de Pereda JM, Calderwood DA, Ulmer TS, Critchley D, Campbell ID, Ginsberg MH, Liddington RC.

Mol Cell. 2003 Jan;11(1):49-58.

15.

The extreme C-terminal region of kindlin-2 is critical to its regulation of integrin activation.

Hirbawi J, Bialkowska K, Bledzka KM, Liu J, Fukuda K, Qin J, Plow EF.

J Biol Chem. 2017 Aug 25;292(34):14258-14269. doi: 10.1074/jbc.M117.776195. Epub 2017 Jun 26.

PMID:
28652408
16.

The N-terminal domains of talin cooperate with the phosphotyrosine binding-like domain to activate beta1 and beta3 integrins.

Bouaouina M, Lad Y, Calderwood DA.

J Biol Chem. 2008 Mar 7;283(10):6118-25. doi: 10.1074/jbc.M709527200. Epub 2007 Dec 28.

17.

Beta1 integrin cytoplasmic tyrosines promote skin tumorigenesis independent of their phosphorylation.

Meves A, Geiger T, Zanivan S, DiGiovanni J, Mann M, Fässler R.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15213-8. doi: 10.1073/pnas.1105689108. Epub 2011 Aug 29.

18.

Effects of mutations in the cytoplasmic domain of integrin beta(1) to talin binding and cell spreading.

Kääpä A, Peter K, Ylänne J.

Exp Cell Res. 1999 Aug 1;250(2):524-34.

PMID:
10413605
19.

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.

Calderwood DA, Fujioka Y, de Pereda JM, García-Alvarez B, Nakamoto T, Margolis B, McGlade CJ, Liddington RC, Ginsberg MH.

Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2272-7. Epub 2003 Feb 26.

20.

The phosphotyrosine binding-like domain of talin activates integrins.

Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg MH.

J Biol Chem. 2002 Jun 14;277(24):21749-58. Epub 2002 Apr 3.

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