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Extracellular matrix lumican promotes bacterial phagocytosis, and Lum-/- mice show increased Pseudomonas aeruginosa lung infection severity.

Shao H, Lee S, Gae-Scott S, Nakata C, Chen S, Hamad AR, Chakravarti S.

J Biol Chem. 2012 Oct 19;287(43):35860-72. doi: 10.1074/jbc.M112.380550. Epub 2012 Aug 3. Erratum in: J Biol Chem. 2014 Dec 5;289(49):33874.


Extracellular matrix protein lumican promotes clearance and resolution of Pseudomonas aeruginosa keratitis in a mouse model.

Shao H, Scott SG, Nakata C, Hamad AR, Chakravarti S.

PLoS One. 2013;8(1):e54765. doi: 10.1371/journal.pone.0054765. Epub 2013 Jan 24.


A novel role of the lumican core protein in bacterial lipopolysaccharide-induced innate immune response.

Wu F, Vij N, Roberts L, Lopez-Briones S, Joyce S, Chakravarti S.

J Biol Chem. 2007 Sep 7;282(36):26409-17. Epub 2007 Jul 5.


Extracellular matrix lumican deposited on the surface of neutrophils promotes migration by binding to beta2 integrin.

Lee S, Bowrin K, Hamad AR, Chakravarti S.

J Biol Chem. 2009 Aug 28;284(35):23662-9. doi: 10.1074/jbc.M109.026229. Epub 2009 Jun 15.


Keratocan, a cornea-specific keratan sulfate proteoglycan, is regulated by lumican.

Carlson EC, Liu CY, Chikama T, Hayashi Y, Kao CW, Birk DE, Funderburgh JL, Jester JV, Kao WW.

J Biol Chem. 2005 Jul 8;280(27):25541-7. Epub 2005 Apr 22.


Functions of lumican and fibromodulin: lessons from knockout mice.

Chakravarti S.

Glycoconj J. 2002 May-Jun;19(4-5):287-93. Review.


Collagen fibril assembly during postnatal development and dysfunctional regulation in the lumican-deficient murine cornea.

Chakravarti S, Zhang G, Chervoneva I, Roberts L, Birk DE.

Dev Dyn. 2006 Sep;235(9):2493-506.


Lumican suppresses cell proliferation and aids Fas-Fas ligand mediated apoptosis: implications in the cornea.

Vij N, Roberts L, Joyce S, Chakravarti S.

Exp Eye Res. 2004 May;78(5):957-71.


Lumican binds ALK5 to promote epithelium wound healing.

Yamanaka O, Yuan Y, Coulson-Thomas VJ, Gesteira TF, Call MK, Zhang Y, Zhang J, Chang SH, Xie C, Liu CY, Saika S, Jester JV, Kao WW.

PLoS One. 2013 Dec 18;8(12):e82730. doi: 10.1371/journal.pone.0082730. eCollection 2013.


Lumican is required for neutrophil extravasation following corneal injury and wound healing.

Hayashi Y, Call MK, Chikama T, Liu H, Carlson EC, Sun Y, Pearlman E, Funderburgh JL, Babcock G, Liu CY, Ohashi Y, Kao WW.

J Cell Sci. 2010 Sep 1;123(Pt 17):2987-95. doi: 10.1242/jcs.068221. Epub 2010 Aug 10.


Targeted expression of a lumican transgene rescues corneal deficiencies in lumican-null mice.

Meij JT, Carlson EC, Wang L, Liu CY, Jester JV, Birk DE, Kao WW.

Mol Vis. 2007 Oct 18;13:2012-8.


Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1.

Carlson EC, Lin M, Liu CY, Kao WW, Perez VL, Pearlman E.

J Biol Chem. 2007 Dec 7;282(49):35502-9. Epub 2007 Oct 2.


Lumican deficiency results in cardiomyocyte hypertrophy with altered collagen assembly.

Dupuis LE, Berger MG, Feldman S, Doucette L, Fowlkes V, Chakravarti S, Thibaudeau S, Alcala NE, Bradshaw AD, Kern CB.

J Mol Cell Cardiol. 2015 Jul;84:70-80. doi: 10.1016/j.yjmcc.2015.04.007. Epub 2015 Apr 15.


Interclass small leucine-rich repeat proteoglycan interactions regulate collagen fibrillogenesis and corneal stromal assembly.

Chen S, Young MF, Chakravarti S, Birk DE.

Matrix Biol. 2014 Apr;35:103-11. doi: 10.1016/j.matbio.2014.01.004. Epub 2014 Jan 18.


Homologous sequence in lumican and fibromodulin leucine-rich repeat 5-7 competes for collagen binding.

Kalamajski S, Oldberg A.

J Biol Chem. 2009 Jan 2;284(1):534-9. doi: 10.1074/jbc.M805721200. Epub 2008 Nov 13.


Role of lumican in the corneal epithelium during wound healing.

Saika S, Shiraishi A, Liu CY, Funderburgh JL, Kao CW, Converse RL, Kao WW.

J Biol Chem. 2000 Jan 28;275(4):2607-12.


Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22.

Chakravarti S, Stallings RL, SundarRaj N, Cornuet PK, Hassell JR.

Genomics. 1995 Jun 10;27(3):481-8.


PTEN limits alveolar macrophage function against Pseudomonas aeruginosa after bone marrow transplantation.

Hubbard LL, Wilke CA, White ES, Moore BB.

Am J Respir Cell Mol Biol. 2011 Nov;45(5):1050-8. doi: 10.1165/rcmb.2011-0079OC. Epub 2011 Apr 28.


Extracellular matrix protein lumican regulates inflammation in a mouse model of colitis.

Lohr K, Sardana H, Lee S, Wu F, Huso DL, Hamad AR, Chakravarti S.

Inflamm Bowel Dis. 2012 Jan;18(1):143-51. doi: 10.1002/ibd.21713. Epub 2011 Apr 11.


Macrophage receptors for lumican. A corneal keratan sulfate proteoglycan.

Funderburgh JL, Mitschler RR, Funderburgh ML, Roth MR, Chapes SK, Conrad GW.

Invest Ophthalmol Vis Sci. 1997 May;38(6):1159-67.


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