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Items: 1 to 20 of 80

1.

[Structure-activity relationship of novel vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists].

Suhara Y, Motoyoshi S, Hirota Y, Sawada N, Nakagawa K, Tokiwa H, Okano T.

Yakugaku Zasshi. 2012;132(8):881-6. Review. Japanese.

2.

Synthesis of novel vitamin K2 analogues with modification at the ω-terminal position and their biological evaluation as potent steroid and xenobiotic receptor (SXR) agonists.

Suhara Y, Watanabe M, Nakagawa K, Wada A, Ito Y, Takeda K, Takahashi K, Okano T.

J Med Chem. 2011 Jun 23;54(12):4269-73. doi: 10.1021/jm200025f. Epub 2011 May 26.

PMID:
21561094
3.

Synthesis of new vitamin K analogues as steroid and xenobiotic receptor (SXR) agonists: insights into the biological role of the side chain part of vitamin K.

Suhara Y, Watanabe M, Motoyoshi S, Nakagawa K, Wada A, Takeda K, Takahashi K, Tokiwa H, Okano T.

J Med Chem. 2011 Jul 14;54(13):4918-22. doi: 10.1021/jm200201k. Epub 2011 Jun 20.

PMID:
21618996
4.

PROX1 suppresses vitamin K-induced transcriptional activity of Steroid and Xenobiotic Receptor.

Azuma K, Urano T, Watabe T, Ouchi Y, Inoue S.

Genes Cells. 2011 Nov;16(11):1063-70. doi: 10.1111/j.1365-2443.2011.01551.x.

5.

Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR.

Tabb MM, Sun A, Zhou C, Grün F, Errandi J, Romero K, Pham H, Inoue S, Mallick S, Lin M, Forman BM, Blumberg B.

J Biol Chem. 2003 Nov 7;278(45):43919-27. Epub 2003 Aug 14.

6.

Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics.

Takeshita A, Taguchi M, Koibuchi N, Ozawa Y.

J Biol Chem. 2002 Sep 6;277(36):32453-8. Epub 2002 Jun 18.

7.

Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene.

Igarashi M, Yogiashi Y, Mihara M, Takada I, Kitagawa H, Kato S.

Mol Cell Biol. 2007 Nov;27(22):7947-54. Epub 2007 Sep 17. Retraction in: Mol Cell Biol. 2014 Mar;34(5):918.

8.

Structure-activity relationship of novel menaquinone-4 analogues: modification of the side chain affects their biological activities.

Suhara Y, Hanada N, Okitsu T, Sakai M, Watanabe M, Nakagawa K, Wada A, Takeda K, Takahashi K, Tokiwa H, Okano T.

J Med Chem. 2012 Feb 23;55(4):1553-8. doi: 10.1021/jm2013166. Epub 2012 Feb 7.

PMID:
22250752
9.

The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.

Zhou C, Verma S, Blumberg B.

Nucl Recept Signal. 2009;7:e001. doi: 10.1621/nrs.07001. Epub 2009 Jan 16. Review.

10.

Steroid and xenobiotic receptor SXR mediates vitamin K2-activated transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells.

Ichikawa T, Horie-Inoue K, Ikeda K, Blumberg B, Inoue S.

J Biol Chem. 2006 Jun 23;281(25):16927-34. Epub 2006 Apr 10.

11.

[Vitamin K function mediated by activation of steroid and xenobiotic receptor].

Azuma K, Inoue S.

Clin Calcium. 2009 Dec;19(12):1770-8. doi: CliCa091217701778. Review. Japanese.

PMID:
19949268
12.

Mitotane induces CYP3A4 expression via activation of the steroid and xenobiotic receptor.

Takeshita A, Igarashi-Migitaka J, Koibuchi N, Takeuchi Y.

J Endocrinol. 2013 Feb 15;216(3):297-305. doi: 10.1530/JOE-12-0297. Print 2013 Mar.

13.

Homologous metabolic and gene activating routes for vitamins E and K.

Landes N, Birringer M, Brigelius-Flohé R.

Mol Aspects Med. 2003 Dec;24(6):337-44. Review.

PMID:
14585304
14.

Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells.

Basseville A, Preisser L, de Carné Trécesson S, Boisdron-Celle M, Gamelin E, Coqueret O, Morel A.

Mol Cancer. 2011 Jul 6;10:80. doi: 10.1186/1476-4598-10-80.

15.
16.

Steroid and xenobiotic receptor mediates a novel vitamin K2 signaling pathway in osteoblastic cells.

Horie-Inoue K, Inoue S.

J Bone Miner Metab. 2008;26(1):9-12. Epub 2008 Jan 10. Review.

PMID:
18095058
17.

Structure-activity relationships in the conversion of vitamin K analogues into menaquinone-4. Substrates essential to the synthesis of menaquinone-4 in cultured human cell lines.

Suhara Y, Wada A, Tachibana Y, Watanabe M, Nakamura K, Nakagawa K, Okano T.

Bioorg Med Chem. 2010 May 1;18(9):3116-24. doi: 10.1016/j.bmc.2010.03.035. Epub 2010 Mar 19.

PMID:
20378364
18.

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR.

Kawana K, Ikuta T, Kobayashi Y, Gotoh O, Takeda K, Kawajiri K.

Mol Pharmacol. 2003 Mar;63(3):524-31.

19.

Interaction of silencing mediator for retinoid and thyroid receptors with steroid and xenobiotic receptor on multidrug resistance 1 promoter.

Hirooka-Masui K, Lesmana R, Iwasaki T, Xu M, Hayasaka K, Haraguchi M, Takeshita A, Shimokawa N, Yamamoto K, Koibuchi N.

Life Sci. 2013 May 20;92(17-19):911-5. doi: 10.1016/j.lfs.2013.03.007. Epub 2013 Apr 3.

PMID:
23562850
20.

Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes.

Zhou C, Tabb MM, Sadatrafiei A, Grün F, Blumberg B.

Drug Metab Dispos. 2004 Oct;32(10):1075-82. Epub 2004 Jul 21.

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