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Aneuploidy as a mechanism for stress-induced liver adaptation.

Duncan AW, Hanlon Newell AE, Bi W, Finegold MJ, Olson SB, Beaudet AL, Grompe M.

J Clin Invest. 2012 Sep;122(9):3307-15. doi: 10.1172/JCI64026. Epub 2012 Aug 6.


Aneuploidy, polyploidy and ploidy reversal in the liver.

Duncan AW.

Semin Cell Dev Biol. 2013 Apr;24(4):347-56. doi: 10.1016/j.semcdb.2013.01.003. Epub 2013 Jan 16. Review.


In vivo selection of transplanted hepatocytes by pharmacological inhibition of fumarylacetoacetate hydrolase in wild-type mice.

Paulk NK, Wursthorn K, Haft A, Pelz C, Clarke G, Newell AH, Olson SB, Harding CO, Finegold MJ, Bateman RL, Witte JF, McClard R, Grompe M.

Mol Ther. 2012 Oct;20(10):1981-7. doi: 10.1038/mt.2012.154. Epub 2012 Aug 7.


Complete rescue of lethal albino c14CoS mice by null mutation of 4-hydroxyphenylpyruvate dioxygenase and induction of apoptosis of hepatocytes in these mice by in vivo retrieval of the tyrosine catabolic pathway.

Endo F, Kubo S, Awata H, Kiwaki K, Katoh H, Kanegae Y, Saito I, Miyazaki J, Yamamoto T, Jakobs C, Hattori S, Matsuda I.

J Biol Chem. 1997 Sep 26;272(39):24426-32.


The ploidy conveyor of mature hepatocytes as a source of genetic variation.

Duncan AW, Taylor MH, Hickey RD, Hanlon Newell AE, Lenzi ML, Olson SB, Finegold MJ, Grompe M.

Nature. 2010 Oct 7;467(7316):707-10. doi: 10.1038/nature09414. Epub 2010 Sep 22.


Aneuploidy screening of embryonic stem cell clones by metaphase karyotyping and droplet digital polymerase chain reaction.

Codner GF, Lindner L, Caulder A, Wattenhofer-Donzé M, Radage A, Mertz A, Eisenmann B, Mianné J, Evans EP, Beechey CV, Fray MD, Birling MC, Hérault Y, Pavlovic G, Teboul L.

BMC Cell Biol. 2016 Aug 5;17(1):30. doi: 10.1186/s12860-016-0108-6.


Ploidy reductions in murine fusion-derived hepatocytes.

Duncan AW, Hickey RD, Paulk NK, Culberson AJ, Olson SB, Finegold MJ, Grompe M.

PLoS Genet. 2009 Feb;5(2):e1000385. doi: 10.1371/journal.pgen.1000385. Epub 2009 Feb 20.


Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development.

Peterson SE, Yang AH, Bushman DM, Westra JW, Yung YC, Barral S, Mutoh T, Rehen SK, Chun J.

J Neurosci. 2012 Nov 14;32(46):16213-22. doi: 10.1523/JNEUROSCI.3706-12.2012.


In vivo suppressor mutations correct a murine model of hereditary tyrosinemia type I.

Manning K, Al-Dhalimy M, Finegold M, Grompe M.

Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11928-33.


Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies.

Bakker B, Taudt A, Belderbos ME, Porubsky D, Spierings DC, de Jong TV, Halsema N, Kazemier HG, Hoekstra-Wakker K, Bradley A, de Bont ES, van den Berg A, Guryev V, Lansdorp PM, Colomé-Tatché M, Foijer F.

Genome Biol. 2016 May 31;17(1):115. doi: 10.1186/s13059-016-0971-7.


Aneuploidy is permissive for hepatocyte-like cell differentiation from human induced pluripotent stem cells.

Noto FK, Determan MR, Cai J, Cayo MA, Mallanna SK, Duncan SA.

BMC Res Notes. 2014 Jul 8;7:437. doi: 10.1186/1756-0500-7-437.


Polar body analysis by array comparative genomic hybridization accurately predicts aneuploidies of maternal meiotic origin in cleavage stage embryos of women of advanced maternal age.

Christopikou D, Tsorva E, Economou K, Shelley P, Davies S, Mastrominas M, Handyside AH.

Hum Reprod. 2013 May;28(5):1426-34. doi: 10.1093/humrep/det053. Epub 2013 Mar 10.


Frequent aneuploidy among normal human hepatocytes.

Duncan AW, Hanlon Newell AE, Smith L, Wilson EM, Olson SB, Thayer MJ, Strom SC, Grompe M.

Gastroenterology. 2012 Jan;142(1):25-8. doi: 10.1053/j.gastro.2011.10.029. Epub 2011 Nov 2.


Low level chromosome instability in embryonic cells of primary aneuploid mice.

Lightfoot DA, Höög C.

Cytogenet Genome Res. 2004;107(1-2):95-8.


Aneuploid chromosomes are highly unstable during DNA transformation of Candida albicans.

Bouchonville K, Forche A, Tang KE, Selmecki A, Berman J.

Eukaryot Cell. 2009 Oct;8(10):1554-66. doi: 10.1128/EC.00209-09. Epub 2009 Aug 21.


Point mutations in the murine fumarylacetoacetate hydrolase gene: Animal models for the human genetic disorder hereditary tyrosinemia type 1.

Aponte JL, Sega GA, Hauser LJ, Dhar MS, Withrow CM, Carpenter DA, Rinchik EM, Culiat CT, Johnson DK.

Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):641-5.


Kidneys of mice with hereditary tyrosinemia type I are extremely sensitive to cytotoxicity.

Jacobs SM, van Beurden DH, Klomp LW, Berger R, van den Berg IE.

Pediatr Res. 2006 Mar;59(3):365-70.


Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.

Donehower LA, Godley LA, Aldaz CM, Pyle R, Shi YP, Pinkel D, Gray J, Bradley A, Medina D, Varmus HE.

Genes Dev. 1995 Apr 1;9(7):882-95.


Animal models of tyrosinemia.

Nakamura K, Tanaka Y, Mitsubuchi H, Endo F.

J Nutr. 2007 Jun;137(6 Suppl 1):1556S-1560S; discussion 1573S-1575S. Review.


Plasticity of hepatic cell differentiation: bipotential adult mouse liver clonal cell lines competent to differentiate in vitro and in vivo.

Fougère-Deschatrette C, Imaizumi-Scherrer T, Strick-Marchand H, Morosan S, Charneau P, Kremsdorf D, Faust DM, Weiss MC.

Stem Cells. 2006 Sep;24(9):2098-109.

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