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Transient inability to manage proteobacteria promotes chronic gut inflammation in TLR5-deficient mice.

Carvalho FA, Koren O, Goodrich JK, Johansson ME, Nalbantoglu I, Aitken JD, Su Y, Chassaing B, Walters WA, González A, Clemente JC, Cullender TC, Barnich N, Darfeuille-Michaud A, Vijay-Kumar M, Knight R, Ley RE, Gewirtz AT.

Cell Host Microbe. 2012 Aug 16;12(2):139-52. doi: 10.1016/j.chom.2012.07.004. Epub 2012 Aug 2.


AIEC pathobiont instigates chronic colitis in susceptible hosts by altering microbiota composition.

Chassaing B, Koren O, Carvalho FA, Ley RE, Gewirtz AT.

Gut. 2014 Jul;63(7):1069-80. doi: 10.1136/gutjnl-2013-304909. Epub 2013 Jul 29.


Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis.

Carvalho FA, Nalbantoglu I, Ortega-Fernandez S, Aitken JD, Su Y, Koren O, Walters WA, Knight R, Ley RE, Vijay-Kumar M, Gewirtz AT.

Gut. 2012 Mar;61(3):373-84. doi: 10.1136/gut.2011.240556. Epub 2011 Jun 5.


Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice.

Chassaing B, Ley RE, Gewirtz AT.

Gastroenterology. 2014 Dec;147(6):1363-77.e17. doi: 10.1053/j.gastro.2014.08.033. Epub 2014 Aug 27.


Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut.

Cullender TC, Chassaing B, Janzon A, Kumar K, Muller CE, Werner JJ, Angenent LT, Bell ME, Hay AG, Peterson DA, Walter J, Vijay-Kumar M, Gewirtz AT, Ley RE.

Cell Host Microbe. 2013 Nov 13;14(5):571-81. doi: 10.1016/j.chom.2013.10.009.


Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice.

Singh V, Chassaing B, Zhang L, San Yeoh B, Xiao X, Kumar M, Baker MT, Cai J, Walker R, Borkowski K, Harvatine KJ, Singh N, Shearer GC, Ntambi JM, Joe B, Patterson AD, Gewirtz AT, Vijay-Kumar M.

Cell Metab. 2015 Dec 1;22(6):983-96. doi: 10.1016/j.cmet.2015.09.028. Epub 2015 Oct 29.


Deletion of TLR5 results in spontaneous colitis in mice.

Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT.

J Clin Invest. 2007 Dec;117(12):3909-21.


TLR5 is not required for flagellin-mediated exacerbation of DSS colitis.

Ivison SM, Himmel ME, Hardenberg G, Wark PA, Kifayet A, Levings MK, Steiner TS.

Inflamm Bowel Dis. 2010 Mar;16(3):401-9. doi: 10.1002/ibd.21097.


Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice.

Klimesova K, Kverka M, Zakostelska Z, Hudcovic T, Hrncir T, Stepankova R, Rossmann P, Ridl J, Kostovcik M, Mrazek J, Kopecny J, Kobayashi KS, Tlaskalova-Hogenova H.

Inflamm Bowel Dis. 2013 May;19(6):1266-77. doi: 10.1097/MIB.0b013e318281330a.


Toll like receptor-5: protecting the gut from enteric microbes.

Vijay-Kumar M, Aitken JD, Gewirtz AT.

Semin Immunopathol. 2008 Feb;30(1):11-21. Epub 2007 Dec 7. Review.


Intestinal steroid profiles and microbiota composition in colitic mice.

Wohlgemuth S, Keller S, Kertscher R, Stadion M, Haller D, Kisling S, Jahreis G, Blaut M, Loh G.

Gut Microbes. 2011 May-Jun;2(3):159-66. doi: 10.4161/gmic.2.3.16104.


Proneness of TLR5 deficient mice to develop colitis is microbiota dependent.

Singh V, Yeoh BS, Carvalho F, Gewirtz AT, Vijay-Kumar M.

Gut Microbes. 2015 Jul 4;6(4):279-83. doi: 10.1080/19490976.2015.1060390. Epub 2015 Jun 11.


Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease.

Vijay-Kumar M, Aitken JD, Kumar A, Neish AS, Uematsu S, Akira S, Gewirtz AT.

Infect Immun. 2008 Mar;76(3):1276-81. doi: 10.1128/IAI.01491-07. Epub 2008 Jan 14.


Mannan-binding lectin deficiency results in unusual antibody production and excessive experimental colitis in response to mannose-expressing mild gut pathogens.

Müller S, Schaffer T, Flogerzi B, Seibold-Schmid B, Schnider J, Takahashi K, Darfeuille-Michaud A, Vazeille E, Schoepfer AM, Seibold F.

Gut. 2010 Nov;59(11):1493-500. doi: 10.1136/gut.2010.208348. Epub 2010 Aug 3.


Proteobacteria-specific IgA regulates maturation of the intestinal microbiota.

Mirpuri J, Raetz M, Sturge CR, Wilhelm CL, Benson A, Savani RC, Hooper LV, Yarovinsky F.

Gut Microbes. 2014 Jan-Feb;5(1):28-39. doi: 10.4161/gmic.26489. Epub 2013 Sep 25.


Commensal gut flora reduces susceptibility to experimentally induced colitis via T-cell-derived interleukin-10.

Pils MC, Bleich A, Prinz I, Fasnacht N, Bollati-Fogolin M, Schippers A, Rozell B, Müller W.

Inflamm Bowel Dis. 2011 Oct;17(10):2038-46. doi: 10.1002/ibd.21587. Epub 2010 Dec 22.


Gut microbiota: Diet promotes dysbiosis and colitis in susceptible hosts.

Sartor RB.

Nat Rev Gastroenterol Hepatol. 2012 Oct;9(10):561-2. doi: 10.1038/nrgastro.2012.157. Epub 2012 Aug 14. No abstract available.


Medicinal lavender modulates the enteric microbiota to protect against Citrobacter rodentium-induced colitis.

Baker J, Brown K, Rajendiran E, Yip A, DeCoffe D, Dai C, Molcan E, Chittick SA, Ghosh S, Mahmoud S, Gibson DL.

Am J Physiol Gastrointest Liver Physiol. 2012 Oct;303(7):G825-36. doi: 10.1152/ajpgi.00327.2011. Epub 2012 Jul 19.


Strain-specific colitis susceptibility in IL10-deficient mice depends on complex gut microbiota-host interactions.

Büchler G, Wos-Oxley ML, Smoczek A, Zschemisch NH, Neumann D, Pieper DH, Hedrich HJ, Bleich A.

Inflamm Bowel Dis. 2012 May;18(5):943-54. doi: 10.1002/ibd.21895. Epub 2012 Jan 11.


Crohn's disease-associated Escherichia coli LF82 aggravates colitis in injured mouse colon via signaling by flagellin.

Carvalho FA, Barnich N, Sauvanet P, Darcha C, Gelot A, Darfeuille-Michaud A.

Inflamm Bowel Dis. 2008 Aug;14(8):1051-60. doi: 10.1002/ibd.20423.


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