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The methyl xanthine caffeine inhibits DNA damage signaling and reactive species and reduces atherosclerosis in ApoE(-/-) mice.

Mercer JR, Gray K, Figg N, Kumar S, Bennett MR.

Arterioscler Thromb Vasc Biol. 2012 Oct;32(10):2461-7. doi: 10.1161/ATVBAHA.112.251322. Epub 2012 Aug 2. Erratum in: Arterioscler Thromb Vasc Biol. 2012 Nov;32(11):e148.


Mitochondrial DNA damage can promote atherosclerosis independently of reactive oxygen species through effects on smooth muscle cells and monocytes and correlates with higher-risk plaques in humans.

Yu E, Calvert PA, Mercer JR, Harrison J, Baker L, Figg NL, Kumar S, Wang JC, Hurst LA, Obaid DR, Logan A, West NE, Clarke MC, Vidal-Puig A, Murphy MP, Bennett MR.

Circulation. 2013 Aug 13;128(7):702-12. doi: 10.1161/CIRCULATIONAHA.113.002271. Epub 2013 Jul 10.


Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis.

Gorenne I, Kumar S, Gray K, Figg N, Yu H, Mercer J, Bennett M.

Circulation. 2013 Jan 22;127(3):386-96. doi: 10.1161/CIRCULATIONAHA.112.124404. Epub 2012 Dec 7.


The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice.

Mercer JR, Yu E, Figg N, Cheng KK, Prime TA, Griffin JL, Masoodi M, Vidal-Puig A, Murphy MP, Bennett MR.

Free Radic Biol Med. 2012 Mar 1;52(5):841-9. doi: 10.1016/j.freeradbiomed.2011.11.026. Epub 2011 Dec 14.


A meprin inhibitor suppresses atherosclerotic plaque formation in ApoE-/- mice.

Gao P, Guo RW, Chen JF, Chen Y, Wang H, Yu Y, Huang L.

Atherosclerosis. 2009 Nov;207(1):84-92. doi: 10.1016/j.atherosclerosis.2009.04.036. Epub 2009 May 4.


DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome.

Mercer JR, Cheng KK, Figg N, Gorenne I, Mahmoudi M, Griffin J, Vidal-Puig A, Logan A, Murphy MP, Bennett M.

Circ Res. 2010 Oct 15;107(8):1021-31. doi: 10.1161/CIRCRESAHA.110.218966. Epub 2010 Aug 12. Erratum in: Circ Res. 2011 Jan 7;108(1):e2.


Txnip ablation reduces vascular smooth muscle cell inflammation and ameliorates atherosclerosis in apolipoprotein E knockout mice.

Byon CH, Han T, Wu J, Hui ST.

Atherosclerosis. 2015 Aug;241(2):313-21. doi: 10.1016/j.atherosclerosis.2015.05.020. Epub 2015 Jun 3.


BRCA1 is a novel target to improve endothelial dysfunction and retard atherosclerosis.

Singh KK, Shukla PC, Quan A, Al-Omran M, Lovren F, Pan Y, Brezden-Masley C, Ingram AJ, Stanford WL, Teoh H, Verma S.

J Thorac Cardiovasc Surg. 2013 Oct;146(4):949-960.e4. doi: 10.1016/j.jtcvs.2012.12.064. Epub 2013 Feb 14.


Accelerated atherosclerosis in Apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1.

Galkina EV, Butcher M, Keller SR, Goff M, Bruce A, Pei H, Sarembock IJ, Sanders JM, Nagelin MH, Srinivasan S, Kulkarni RN, Hedrick CC, Lattanzio FA, Dobrian AD, Nadler JL, Ley K.

Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):247-56. doi: 10.1161/ATVBAHA.111.240358. Epub 2011 Dec 22.


Expression of human tissue factor pathway inhibitor on vascular smooth muscle cells inhibits secretion of macrophage migration inhibitory factor and attenuates atherosclerosis in ApoE-/- mice.

Chen D, Xia M, Hayford C, Tham el-L, Semik V, Hurst S, Chen Y, Tam HH, Pan J, Wang Y, Tan X, Lan HY, Shen H, Kakkar VV, Xu Q, McVey JH, Dorling A.

Circulation. 2015 Apr 14;131(15):1350-60. doi: 10.1161/CIRCULATIONAHA.114.013423. Epub 2015 Feb 12.


Human plasminogen kringle 1-5 reduces atherosclerosis and neointima formation in mice by suppressing the inflammatory signaling pathway.

Chang PC, Wu HL, Lin HC, Wang KC, Shi GY.

J Thromb Haemost. 2010 Jan;8(1):194-201. doi: 10.1111/j.1538-7836.2009.03671.x. Epub 2009 Oct 30.


Early hypercholesterolemia contributes to vasomotor dysfunction and injury associated atherogenesis that can be inhibited by nitric oxide.

Raman KG, Gandley RE, Rohland J, Zenati MS, Tzeng E.

J Vasc Surg. 2011 Mar;53(3):754-63. doi: 10.1016/j.jvs.2010.09.038. Epub 2010 Dec 15.


Dextromethorphan reduces oxidative stress and inhibits atherosclerosis and neointima formation in mice.

Liu SL, Li YH, Shi GY, Tang SH, Jiang SJ, Huang CW, Liu PY, Hong JS, Wu HL.

Cardiovasc Res. 2009 Apr 1;82(1):161-9. doi: 10.1093/cvr/cvp043. Epub 2009 Feb 3.


Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice.

Mercer J, Figg N, Stoneman V, Braganza D, Bennett MR.

Circ Res. 2005 Apr 1;96(6):667-74. Epub 2005 Mar 3.


FoxO4 inhibits atherosclerosis through its function in bone marrow derived cells.

Zhu M, Zhang QJ, Wang L, Li H, Liu ZP.

Atherosclerosis. 2011 Dec;219(2):492-8. doi: 10.1016/j.atherosclerosis.2011.09.038. Epub 2011 Oct 2.


Decreased levels of lipid peroxidation-induced DNA damage in the onset of atherogenesis in apolipoprotein E deficient mice.

Godschalk RW, Albrecht C, Curfs DM, Schins RP, Bartsch H, van Schooten FJ, Nair J.

Mutat Res. 2007 Aug 1;621(1-2):87-94. Epub 2007 Mar 2.


Myricitrin attenuates endothelial cell apoptosis to prevent atherosclerosis: An insight into PI3K/Akt activation and STAT3 signaling pathways.

Qin M, Luo Y, Meng XB, Wang M, Wang HW, Song SY, Ye JX, Pan RL, Yao F, Wu P, Sun GB, Sun XB.

Vascul Pharmacol. 2015 Jul;70:23-34. doi: 10.1016/j.vph.2015.03.002. Epub 2015 Apr 4.


Early inflammatory reactions in atherosclerosis are induced by proline-rich tyrosine kinase/reactive oxygen species-mediated release of tumor necrosis factor-alpha and subsequent activation of the p21Cip1/Ets-1/p300 system.

Katsume A, Okigaki M, Matsui A, Che J, Adachi Y, Kishita E, Yamaguchi S, Ikeda K, Ueyama T, Matoba S, Yamada H, Matsubara H.

Arterioscler Thromb Vasc Biol. 2011 May;31(5):1084-92. doi: 10.1161/ATVBAHA.110.221804. Epub 2011 Mar 3. Retraction in: Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):e6.


Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling.

Gray SP, Di Marco E, Kennedy K, Chew P, Okabe J, El-Osta A, Calkin AC, Biessen EA, Touyz RM, Cooper ME, Schmidt HH, Jandeleit-Dahm KA.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):295-307. doi: 10.1161/ATVBAHA.115.307012. Epub 2015 Dec 29.


Carvacrol inhibits atherosclerotic neointima formation by downregulating reactive oxygen species production in vascular smooth muscle cells.

Lee KP, Sudjarwo GW, Jung SH, Lee D, Lee DY, Lee GB, Baek S, Kim DY, Lee HM, Kim B, Kwon SC, Won KJ.

Atherosclerosis. 2015 Jun;240(2):367-73. doi: 10.1016/j.atherosclerosis.2015.03.038. Epub 2015 Mar 28.


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