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Items: 1 to 20 of 104

1.

Structure analysis between the SWAP-70 RHO-GEF and the newly described PLD2-GEF.

Gomez-Cambronero J.

Small GTPases. 2012 Oct-Dec;3(4):202-8. doi: 10.4161/sgtp.20887. Epub 2012 Aug 3.

2.

Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2.

Mahankali M, Peng HJ, Henkels KM, Dinauer MC, Gomez-Cambronero J.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19617-22. doi: 10.1073/pnas.1114692108. Epub 2011 Nov 21.

3.

Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activity.

Mahankali M, Henkels KM, Alter G, Gomez-Cambronero J.

J Biol Chem. 2012 Nov 30;287(49):41417-31. doi: 10.1074/jbc.M112.383596. Epub 2012 Oct 3.

4.

A minimal Rac activation domain in the unconventional guanine nucleotide exchange factor Dock180.

Wu X, Ramachandran S, Lin MC, Cerione RA, Erickson JW.

Biochemistry. 2011 Feb 15;50(6):1070-80. doi: 10.1021/bi100971y. Epub 2011 Jan 20.

5.

The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF).

Gomez-Cambronero J.

Cell Signal. 2011 Dec;23(12):1885-95. doi: 10.1016/j.cellsig.2011.06.017. Epub 2011 Jun 29. Review.

6.

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

Jaiswal M, Gremer L, Dvorsky R, Haeusler LC, Cirstea IC, Uhlenbrock K, Ahmadian MR.

J Biol Chem. 2011 May 20;286(20):18202-12. doi: 10.1074/jbc.M111.226431. Epub 2011 Mar 28.

7.

Specific recognition of Rac2 and Cdc42 by DOCK2 and DOCK9 guanine nucleotide exchange factors.

Kwofie MA, Skowronski J.

J Biol Chem. 2008 Feb 8;283(6):3088-96. Epub 2007 Dec 3.

8.

Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system.

Gupta S, Lee A, Hu C, Fanzo J, Goldberg I, Cattoretti G, Pernis AB.

Hum Immunol. 2003 Apr;64(4):389-401.

PMID:
12651066
9.

In vitro guanine nucleotide exchange activity of DHR-2/DOCKER/CZH2 domains.

Côté JF, Vuori K.

Methods Enzymol. 2006;406:41-57.

PMID:
16472648
10.

Mechanism of enzymatic reaction and protein-protein interactions of PLD from a 3D structural model.

Mahankali M, Alter G, Gomez-Cambronero J.

Cell Signal. 2015 Jan;27(1):69-81. doi: 10.1016/j.cellsig.2014.09.008. Epub 2014 Oct 12.

11.

Real-time NMR study of guanine nucleotide exchange and activation of RhoA by PDZ-RhoGEF.

Gasmi-Seabrook GM, Marshall CB, Cheung M, Kim B, Wang F, Jang YJ, Mak TW, Stambolic V, Ikura M.

J Biol Chem. 2010 Feb 19;285(8):5137-45. doi: 10.1074/jbc.M109.064691. Epub 2009 Dec 17.

12.

Phospholipase D2 induces stress fiber formation through mediating nucleotide exchange for RhoA.

Jeon H, Kwak D, Noh J, Lee MN, Lee CS, Suh PG, Ryu SH.

Cell Signal. 2011 Aug;23(8):1320-6. doi: 10.1016/j.cellsig.2011.03.014. Epub 2011 Mar 31.

PMID:
21440060
13.

A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migration.

Mahankali M, Henkels KM, Gomez-Cambronero J.

J Cell Sci. 2013 Mar 15;126(Pt 6):1416-28. doi: 10.1242/jcs.117960. Epub 2013 Feb 1.

14.

Structure of the Rho-specific guanine nucleotide-exchange factor Xpln.

Murayama K, Kato-Murayama M, Akasaka R, Terada T, Yokoyama S, Shirouzu M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1455-9. doi: 10.1107/S1744309112045265. Epub 2012 Nov 19.

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18.

The guanine nucleotide exchange factor Tiam1: a Janus-faced molecule in cellular signaling.

Boissier P, Huynh-Do U.

Cell Signal. 2014 Mar;26(3):483-91. doi: 10.1016/j.cellsig.2013.11.034. Epub 2013 Dec 2. Review.

PMID:
24308970
19.

Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF.

Chen Z, Guo L, Sprang SR, Sternweis PC.

Protein Sci. 2011 Jan;20(1):107-17. doi: 10.1002/pro.542.

20.

SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling.

Shinohara M, Terada Y, Iwamatsu A, Shinohara A, Mochizuki N, Higuchi M, Gotoh Y, Ihara S, Nagata S, Itoh H, Fukui Y, Jessberger R.

Nature. 2002 Apr 18;416(6882):759-63.

PMID:
11961559

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