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Items: 1 to 20 of 135

1.

The innate immune protein Nod2 binds directly to MDP, a bacterial cell wall fragment.

Grimes CL, Ariyananda Lde Z, Melnyk JE, O'Shea EK.

J Am Chem Soc. 2012 Aug 22;134(33):13535-7. doi: 10.1021/ja303883c. Epub 2012 Aug 13.

2.

Pathogen sensing by nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is mediated by direct binding to muramyl dipeptide and ATP.

Mo J, Boyle JP, Howard CB, Monie TP, Davis BK, Duncan JA.

J Biol Chem. 2012 Jun 29;287(27):23057-67. doi: 10.1074/jbc.M112.344283. Epub 2012 May 1.

3.

Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components.

Lee KH, Biswas A, Liu YJ, Kobayashi KS.

J Biol Chem. 2012 Nov 16;287(47):39800-11. doi: 10.1074/jbc.M112.410027. Epub 2012 Sep 27.

4.
5.

Freund's adjuvant, NOD2 and mycobacteria.

Behr MA, Divangahi M.

Curr Opin Microbiol. 2015 Feb;23:126-32. doi: 10.1016/j.mib.2014.11.015. Epub 2014 Dec 5. Review.

PMID:
25483349
6.

Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide.

Coulombe F, Divangahi M, Veyrier F, de Léséleuc L, Gleason JL, Yang Y, Kelliher MA, Pandey AK, Sassetti CM, Reed MB, Behr MA.

J Exp Med. 2009 Aug 3;206(8):1709-16. doi: 10.1084/jem.20081779. Epub 2009 Jul 6.

7.

Muramyl peptides activate innate immunity conjointly via YB1 and NOD2.

Laman AG, Lathe R, Shepelyakovskaya AO, Gartseva A, Brovko FA, Guryanova S, Alekseeva L, Meshcheryakova EA, Ivanov VT.

Innate Immun. 2016 Nov;22(8):666-673. doi: 10.1177/1753425916668982. Epub 2016 Sep 30.

PMID:
27694635
8.

Identification of a synthetic muramyl peptide derivative with enhanced Nod2 stimulatory capacity.

Rubino SJ, Magalhaes JG, Philpott D, Bahr GM, Blanot D, Girardin SE.

Innate Immun. 2013 Oct;19(5):493-503. doi: 10.1177/1753425912471691. Epub 2013 Jan 22.

PMID:
23339926
9.

Synthesis of biologically active biotinylated muramyl dipeptides.

Grimes CL, Podolsky DK, O'Shea EK.

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6061-3. doi: 10.1016/j.bmcl.2010.08.056. Epub 2010 Aug 17.

10.

Blau syndrome-associated Nod2 mutation alters expression of full-length NOD2 and limits responses to muramyl dipeptide in knock-in mice.

Dugan J, Griffiths E, Snow P, Rosenzweig H, Lee E, Brown B, Carr DW, Rose C, Rosenbaum J, Davey MP.

J Immunol. 2015 Jan 1;194(1):349-57. doi: 10.4049/jimmunol.1402330. Epub 2014 Nov 26.

11.

Computational studies on receptor-ligand interactions between novel buffalo (Bubalus bubalis) nucleotide-binding oligomerization domain-containing protein 2 (NOD2) variants and muramyl dipeptide (MDP).

Brahma B, Patra MC, Mishra P, De BC, Kumar S, Maharana J, Vats A, Ahlawat S, Datta TK, De S.

J Mol Graph Model. 2016 Apr;65:15-26. doi: 10.1016/j.jmgm.2016.02.004. Epub 2016 Feb 10.

PMID:
26897084
12.

Lipophilic Muramyl Dipeptide-Antigen Conjugates as Immunostimulating Agents.

Willems MM, Zom GG, Meeuwenoord N, Khan S, Ossendorp F, Overkleeft HS, van der Marel GA, Filippov DV, Codée JD.

ChemMedChem. 2016 Jan 19;11(2):190-8. doi: 10.1002/cmdc.201500196. Epub 2015 Jun 9.

PMID:
26059481
13.

Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation.

Marina-García N, Franchi L, Kim YG, Hu Y, Smith DE, Boons GJ, Núñez G.

J Immunol. 2009 Apr 1;182(7):4321-7. doi: 10.4049/jimmunol.0802197.

14.

Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease.

van Heel DA, Ghosh S, Hunt KA, Mathew CG, Forbes A, Jewell DP, Playford RJ.

Gut. 2005 Nov;54(11):1553-7. Epub 2005 May 31.

15.

Muramyl dipeptide mediated activation of human bronchial epithelial cells interacting with basophils: a novel mechanism of airway inflammation.

Qiu HN, Wong CK, Chu IM, Hu S, Lam CW.

Clin Exp Immunol. 2013 Apr;172(1):81-94. doi: 10.1111/cei.12031.

16.

Structural insights into the MDP binding and CARD-CARD interaction in zebrafish (Danio rerio) NOD2: a molecular dynamics approach.

Maharana J, Patra MC, De BC, Sahoo BR, Behera BK, De S, Pradhan SK.

J Mol Recognit. 2014 May;27(5):260-75. doi: 10.1002/jmr.2357.

PMID:
24700593
17.

Chronic stimulation of Nod2 mediates tolerance to bacterial products.

Hedl M, Li J, Cho JH, Abraham C.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19440-5. Epub 2007 Nov 21.

18.

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling.

Nakamura N, Lill JR, Phung Q, Jiang Z, Bakalarski C, de Mazière A, Klumperman J, Schlatter M, Delamarre L, Mellman I.

Nature. 2014 May 8;509(7499):240-4. doi: 10.1038/nature13133. Epub 2014 Mar 30.

PMID:
24695226
19.
20.

Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.

Inohara N, Ogura Y, Fontalba A, Gutierrez O, Pons F, Crespo J, Fukase K, Inamura S, Kusumoto S, Hashimoto M, Foster SJ, Moran AP, Fernandez-Luna JL, Nuñez G.

J Biol Chem. 2003 Feb 21;278(8):5509-12. Epub 2003 Jan 4.

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