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Items: 1 to 20 of 42

1.

Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing.

Ri M, Tashiro E, Oikawa D, Shinjo S, Tokuda M, Yokouchi Y, Narita T, Masaki A, Ito A, Ding J, Kusumoto S, Ishida T, Komatsu H, Shiotsu Y, Ueda R, Iwawaki T, Imoto M, Iida S.

Blood Cancer J. 2012 Jul;2(7):e79. doi: 10.1038/bcj.2012.26. Epub 2012 Jul 20.

2.

Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells.

Davenport EL, Moore HE, Dunlop AS, Sharp SY, Workman P, Morgan GJ, Davies FE.

Blood. 2007 Oct 1;110(7):2641-9. Epub 2007 May 24.

3.

Protein kinase CK2 protects multiple myeloma cells from ER stress-induced apoptosis and from the cytotoxic effect of HSP90 inhibition through regulation of the unfolded protein response.

Manni S, Brancalion A, Tubi LQ, Colpo A, Pavan L, Cabrelle A, Ave E, Zaffino F, Di Maira G, Ruzzene M, Adami F, Zambello R, Pitari MR, Tassone P, Pinna LA, Gurrieri C, Semenzato G, Piazza F.

Clin Cancer Res. 2012 Apr 1;18(7):1888-900. doi: 10.1158/1078-0432.CCR-11-1789. Epub 2012 Feb 20.

4.

Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1.

Zhang HM, Ye X, Su Y, Yuan J, Liu Z, Stein DA, Yang D.

J Virol. 2010 Sep;84(17):8446-59. doi: 10.1128/JVI.01416-09. Epub 2010 Jun 16.

5.
6.

Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response.

Chalmers F, van Lith M, Sweeney B, Cain K, Bulleid NJ.

Wellcome Open Res. 2017 Oct 9;2:36. doi: 10.12688/wellcomeopenres.11764.2. eCollection 2017.

8.

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.

Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL.

Diabetes. 2005 Feb;54(2):452-61.

9.

Caspase-2 functions upstream of mitochondria in endoplasmic reticulum stress-induced apoptosis by bortezomib in human myeloma cells.

Gu H, Chen X, Gao G, Dong H.

Mol Cancer Ther. 2008 Aug;7(8):2298-307. doi: 10.1158/1535-7163.MCT-08-0186.

10.

ER stress and distinct outputs of the IRE1α RNase control proliferation and senescence in response to oncogenic Ras.

Blazanin N, Son J, Craig-Lucas AB, John CL, Breech KJ, Podolsky MA, Glick AB.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):9900-9905. doi: 10.1073/pnas.1701757114. Epub 2017 Aug 28.

PMID:
28847931
11.

Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress.

Jiang CC, Lucas K, Avery-Kiejda KA, Wade M, deBock CE, Thorne RF, Allen J, Hersey P, Zhang XD.

Cancer Res. 2008 Aug 15;68(16):6708-17. doi: 10.1158/0008-5472.CAN-08-0349.

12.

Involvement of double-stranded RNA-dependent protein kinase in ER stress-induced retinal neuron damage.

Shimazawa M, Ito Y, Inokuchi Y, Hara H.

Invest Ophthalmol Vis Sci. 2007 Aug;48(8):3729-36.

PMID:
17652745
13.

Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response.

Jiang CC, Chen LH, Gillespie S, Kiejda KA, Mhaidat N, Wang YF, Thorne R, Zhang XD, Hersey P.

Cancer Res. 2007 Jun 15;67(12):5880-8.

14.

20(S)-Protopanaxadiol, a metabolite of ginsenosides, induced cell apoptosis through endoplasmic reticulum stress in human hepatocarcinoma HepG2 cells.

Zhu GY, Li YW, Tse AK, Hau DK, Leung CH, Yu ZL, Fong WF.

Eur J Pharmacol. 2011 Oct 1;668(1-2):88-98. doi: 10.1016/j.ejphar.2011.06.008. Epub 2011 Jun 17.

PMID:
21703260
15.

Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma.

Jiang D, Tam AB, Alagappan M, Hay MP, Gupta A, Kozak MM, Solow-Cordero DE, Lum PY, Denko NC, Giaccia AJ, Le QT, Niwa M, Koong AC.

Mol Cancer Ther. 2016 Sep;15(9):2055-65. doi: 10.1158/1535-7163.MCT-15-1023. Epub 2016 Jun 15.

16.

XBP1-FoxO1 interaction regulates ER stress-induced autophagy in auditory cells.

Kishino A, Hayashi K, Hidai C, Masuda T, Nomura Y, Oshima T.

Sci Rep. 2017 Jun 30;7(1):4442. doi: 10.1038/s41598-017-02960-1.

17.

Phosphorylated PKR contributes the induction of GRP94 under ER stress.

Ito M, Onuki R, Bando Y, Tohyama M, Sugiyama Y.

Biochem Biophys Res Commun. 2007 Aug 31;360(3):615-20. Epub 2007 Jun 26.

PMID:
17612505
18.

IRE1α-XBP1 pathway promotes melanoma progression by regulating IL-6/STAT3 signaling.

Chen C, Zhang X.

J Transl Med. 2017 Feb 21;15(1):42. doi: 10.1186/s12967-017-1147-2.

19.

Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells.

Huang X, Zhang Z, Jia L, Zhao Y, Zhang X, Wu K.

Cancer Lett. 2010 Oct 1;296(1):123-31. doi: 10.1016/j.canlet.2010.04.002.

PMID:
20435408
20.

Identification of a consensus element recognized and cleaved by IRE1 alpha.

Oikawa D, Tokuda M, Hosoda A, Iwawaki T.

Nucleic Acids Res. 2010 Oct;38(18):6265-73. doi: 10.1093/nar/gkq452. Epub 2010 May 27.

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