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Control of cyclooxygenase-2 expression and tumorigenesis by endogenous 5-methoxytryptophan.

Cheng HH, Kuo CC, Yan JL, Chen HL, Lin WC, Wang KH, Tsai KK, Guvén H, Flaberg E, Szekely L, Klein G, Wu KK.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13231-6. doi: 10.1073/pnas.1209919109. Epub 2012 Jul 31.


Inhibition of cancer cell epithelial mesenchymal transition by normal fibroblasts via production of 5-methoxytryptophan.

Cheng HH, Chu LY, Chiang LY, Chen HL, Kuo CC, Wu KK.

Oncotarget. 2016 May 24;7(21):31243-56. doi: 10.18632/oncotarget.9111.


5-methoxyindole metabolites of L-tryptophan: control of COX-2 expression, inflammation and tumorigenesis.

Wu KK, Cheng HH, Chang TC.

J Biomed Sci. 2014 Mar 3;21:17. doi: 10.1186/1423-0127-21-17. Review.


5-Methoxytryptophan-dependent inhibition of oral squamous cell carcinoma metastasis.

Wang SH, Chang CW, Chou HC.

Electrophoresis. 2015 Sep;36(17):2027-34. doi: 10.1002/elps.201500154. Epub 2015 Jul 14.


Quiescent and proliferative fibroblasts exhibit differential p300 HAT activation through control of 5-methoxytryptophan production.

Cheng HH, Wang KH, Chu LY, Chang TC, Kuo CC, Wu KK.

PLoS One. 2014 Feb 11;9(2):e88507. doi: 10.1371/journal.pone.0088507. eCollection 2014.


Antitumor effects of inhibitors of nitric oxide synthase or cyclooxygenase-2 on human KB carcinoma cells overexpressing COX-2.

Ohtsu N, Takaoka K, Segawa E, Hashitani S, Noguchi K, Kishimoto H, Urade M.

Oncol Rep. 2010 Jul;24(1):31-6.


Inhibition of cyclooxygenase-2 by tetramethylpyrazine and its effects on A549 cell invasion and metastasis.

Zheng CY, Xiao W, Zhu MX, Pan XJ, Yang ZH, Zhou SY.

Int J Oncol. 2012 Jun;40(6):2029-37. doi: 10.3892/ijo.2012.1375. Epub 2012 Feb 16.


Green tea polyphenol (-)-epigallocatechin-3-gallate inhibits cyclooxygenase-2 expression in colon carcinogenesis.

Peng G, Dixon DA, Muga SJ, Smith TJ, Wargovich MJ.

Mol Carcinog. 2006 May;45(5):309-19.


Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model.

Xin X, Majumder M, Girish GV, Mohindra V, Maruyama T, Lala PK.

Lab Invest. 2012 Aug;92(8):1115-28. doi: 10.1038/labinvest.2012.90. Epub 2012 May 28.


Radiation-enhancement of MDA-MB-231 breast cancer cell invasion prevented by a cyclooxygenase-2 inhibitor.

Paquette B, Therriault H, Desmarais G, Wagner R, Royer R, Bujold R.

Br J Cancer. 2011 Aug 9;105(4):534-41. doi: 10.1038/bjc.2011.260. Epub 2011 Jul 26.


Antitumor and anti-metastatic effects of cyclooxygenase-2 inhibition by celecoxib on human colorectal carcinoma xenografts in nude mouse rectum.

Ninomiya I, Nagai N, Oyama K, Hayashi H, Tajima H, Kitagawa H, Fushida S, Fujimura T, Ohta T.

Oncol Rep. 2012 Sep;28(3):777-84. doi: 10.3892/or.2012.1885. Epub 2012 Jun 26.


Cyclooxygenase inhibitors decrease the growth and induce regression of human esophageal adenocarcinoma xenografts in nude mice.

Santander S, Cebrián C, Esquivias P, Conde B, Esteva F, Jiménez P, Ortego J, Lanas A, Piazuelo E.

Int J Oncol. 2012 Feb;40(2):527-34. doi: 10.3892/ijo.2011.1219. Epub 2011 Oct 3.


Endothelium-Derived 5-Methoxytryptophan Is a Circulating Anti-Inflammatory Molecule That Blocks Systemic Inflammation.

Wang YF, Hsu YJ, Wu HF, Lee GL, Yang YS, Wu JY, Yet SF, Wu KK, Kuo CC.

Circ Res. 2016 Jul 8;119(2):222-36. doi: 10.1161/CIRCRESAHA.116.308559. Epub 2016 May 5. Erratum in: Circ Res. 2016 Sep 2;119(6):e108.


The cyclooxygenase-2 inhibitor NS-398 inhibits proliferation and induces apoptosis in human osteosarcoma cells via downregulation of the survivin pathway.

Duan DP, Dang XQ, Wang KZ, Wang YP, Zhang H, You WL.

Oncol Rep. 2012 Nov;28(5):1693-700. doi: 10.3892/or.2012.1992. Epub 2012 Aug 24.


In vitro and in vivo inhibitory effect evaluation of cyclooxygenase-2 inhibitors, antisense cyclooxygenase-2 cDNA, and their combination on the growth of human bladder cancer cells.

Qin J, Yuan J, Li L, Liu H, Qin R, Qin W, Chen B, Wang H, Wu K.

Biomed Pharmacother. 2009 Mar;63(3):241-8. doi: 10.1016/j.biopha.2008.04.007. Epub 2008 May 23.


Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells.

Spinella F, Rosanò L, Di Castro V, Nicotra MR, Natali PG, Bagnato A.

Clin Cancer Res. 2004 Jul 15;10(14):4670-9.


Inhibition of cell survival, cell cycle progression, tumor growth and cyclooxygenase-2 activity in MDA-MB-231 breast cancer cells by camphorataimide B.

Lin WL, Lee YJ, Wang SM, Huang PY, Tseng TH.

Eur J Pharmacol. 2012 Apr 5;680(1-3):8-15. doi: 10.1016/j.ejphar.2012.01.032. Epub 2012 Feb 10.


Cyclooxygenase-2 is involved in S100A2-mediated tumor suppression in squamous cell carcinoma.

Tsai WC, Tsai ST, Jin YT, Wu LW.

Mol Cancer Res. 2006 Aug;4(8):539-47.


Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion.

Nystrom ML, McCulloch D, Weinreb PH, Violette SM, Speight PM, Marshall JF, Hart IR, Thomas GJ.

Cancer Res. 2006 Nov 15;66(22):10833-42.


Cyclooxygenase-2 inhibition prevents migration of colorectal cancer cells to extracellular matrix by down-regulation of matrix metalloproteinase-2 expression.

Leung E, McArthur D, Morris A, Williams N.

Dis Colon Rectum. 2008 Mar;51(3):342-7. doi: 10.1007/s10350-007-9120-4. Epub 2008 Jan 29.


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