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Items: 1 to 20 of 111

1.

An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.

Nelson AC, Pillay N, Henderson S, Presneau N, Tirabosco R, Halai D, Berisha F, Flicek P, Stemple DL, Stern CD, Wardle FC, Flanagan AM.

J Pathol. 2012 Nov;228(3):274-85. doi: 10.1002/path.4082. Epub 2012 Sep 26.

PMID:
22847733
2.

'The chicken or the egg?' dilemma strikes back for the controlling mechanism in chordoma(#).

Szuhai K, Hogendoorn PC.

J Pathol. 2012 Nov;228(3):261-5. doi: 10.1002/path.4102.

PMID:
22952146
3.

Brachyury and chordoma: the chondroid-chordoid dilemma resolved?

Romeo S, Hogendoorn PC.

J Pathol. 2006 Jun;209(2):143-6.

PMID:
16604512
4.

Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target.

Hsu W, Mohyeldin A, Shah SR, ap Rhys CM, Johnson LF, Sedora-Roman NI, Kosztowski TA, Awad OA, McCarthy EF, Loeb DM, Wolinsky JP, Gokaslan ZL, Quiñones-Hinojosa A.

J Neurosurg. 2011 Oct;115(4):760-9. doi: 10.3171/2011.5.JNS11185. Epub 2011 Jun 24.

5.

From notochord formation to hereditary chordoma: the many roles of Brachyury.

Nibu Y, José-Edwards DS, Di Gregorio A.

Biomed Res Int. 2013;2013:826435. doi: 10.1155/2013/826435. Epub 2013 Mar 31. Review.

6.

Analysis of the fibroblastic growth factor receptor-RAS/RAF/MEK/ERK-ETS2/brachyury signalling pathway in chordomas.

Shalaby AA, Presneau N, Idowu BD, Thompson L, Briggs TR, Tirabosco R, Diss TC, Flanagan AM.

Mod Pathol. 2009 Aug;22(8):996-1005. doi: 10.1038/modpathol.2009.63. Epub 2009 May 1.

7.

Genomic targets of Brachyury (T) in differentiating mouse embryonic stem cells.

Evans AL, Faial T, Gilchrist MJ, Down T, Vallier L, Pedersen RA, Wardle FC, Smith JC.

PLoS One. 2012;7(3):e33346. doi: 10.1371/journal.pone.0033346. Epub 2012 Mar 30.

8.

The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival.

Hu Y, Mintz A, Shah SR, Quinones-Hinojosa A, Hsu W.

Carcinogenesis. 2014 Jul;35(7):1491-9. doi: 10.1093/carcin/bgu014. Epub 2014 Jan 20.

9.

Mesoderm formation in response to Brachyury requires FGF signalling.

Schulte-Merker S, Smith JC.

Curr Biol. 1995 Jan 1;5(1):62-7.

10.

The brachyury Gly177Asp SNP is not associated with a risk of skull base chordoma in the Chinese population.

Wu Z, Wang K, Wang L, Feng J, Hao S, Tian K, Zhang L, Jia G, Wan H, Zhang J.

Int J Mol Sci. 2013 Oct 25;14(11):21258-65. doi: 10.3390/ijms141121258.

11.

Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.

Presneau N, Shalaby A, Ye H, Pillay N, Halai D, Idowu B, Tirabosco R, Whitwell D, Jacques TS, Kindblom LG, Brüderlein S, Möller P, Leithner A, Liegl B, Amary FM, Athanasou NN, Hogendoorn PC, Mertens F, Szuhai K, Flanagan AM.

J Pathol. 2011 Feb;223(3):327-35. doi: 10.1002/path.2816. Epub 2010 Nov 24.

PMID:
21171078
12.

Molecular profiling of chordoma.

Scheil-Bertram S, Kappler R, von Baer A, Hartwig E, Sarkar M, Serra M, Brüderlein S, Westhoff B, Melzner I, Bassaly B, Herms J, Hugo HH, Schulte M, Möller P.

Int J Oncol. 2014 Apr;44(4):1041-55. doi: 10.3892/ijo.2014.2268. Epub 2014 Jan 21.

13.

Brachyury-downstream gene sets in a chordate, Ciona intestinalis: integrating notochord specification, morphogenesis and chordate evolution.

Hotta K, Takahashi H, Satoh N, Gojobori T.

Evol Dev. 2008 Jan-Feb;10(1):37-51. doi: 10.1111/j.1525-142X.2007.00212.x.

PMID:
18184356
14.

Brachyury, a crucial regulator of notochordal development, is a novel biomarker for chordomas.

Vujovic S, Henderson S, Presneau N, Odell E, Jacques TS, Tirabosco R, Boshoff C, Flanagan AM.

J Pathol. 2006 Jun;209(2):157-65.

PMID:
16538613
15.

Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue.

Tirabosco R, Mangham DC, Rosenberg AE, Vujovic S, Bousdras K, Pizzolitto S, De Maglio G, den Bakker MA, Di Francesco L, Kalil RK, Athanasou NA, O'Donnell P, McCarthy EF, Flanagan AM.

Am J Surg Pathol. 2008 Apr;32(4):572-80. doi: 10.1097/PAS.0b013e31815b693a.

PMID:
18301055
16.

[Novel molecular aspects of chordomas].

Scheil-Bertram S.

Pathologe. 2014 Nov;35 Suppl 2:237-41. doi: 10.1007/s00292-014-1986-z. German.

PMID:
25394972
17.

T (brachyury) gene duplication confers major susceptibility to familial chordoma.

Yang XR, Ng D, Alcorta DA, Liebsch NJ, Sheridan E, Li S, Goldstein AM, Parry DM, Kelley MJ.

Nat Genet. 2009 Nov;41(11):1176-8. doi: 10.1038/ng.454. Epub 2009 Oct 4.

18.

Classic chordoma coexisting with benign notochordal cell rest demonstrating different immunohistological expression patterns of brachyury and galectin-3.

Shen J, Li CD, Yang HL, Lu J, Zou TM, Wang DL, Deng M.

J Clin Neurosci. 2011 Jan;18(1):96-9. doi: 10.1016/j.jocn.2010.03.066. Epub 2010 Sep 19.

PMID:
20855213
19.

Novel therapeutic targets in chordoma.

Bydon M, Papadimitriou K, Witham T, Wolinsky JP, Bydon A, Sciubba D, Gokaslan Z.

Expert Opin Ther Targets. 2012 Nov;16(11):1139-43. doi: 10.1517/14728222.2012.714772. Epub 2012 Aug 4. Review.

PMID:
22860993
20.

Tissue microarray immunohistochemical detection of brachyury is not a prognostic indicator in chordoma.

Zhang L, Guo S, Schwab JH, Nielsen GP, Choy E, Ye S, Zhang Z, Mankin H, Hornicek FJ, Duan Z.

PLoS One. 2013 Sep 23;8(9):e75851. doi: 10.1371/journal.pone.0075851. eCollection 2013.

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