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GNAS1 and PHD2 short-interfering RNA support bone regeneration in vitro and in an in vivo sheep model.

Ríos CN, Skoracki RJ, Mathur AB.

Clin Orthop Relat Res. 2012 Sep;470(9):2541-53. doi: 10.1007/s11999-012-2475-4.


Noggin suppression decreases BMP-2-induced osteogenesis of human bone marrow-derived mesenchymal stem cells in vitro.

Chen C, Uludağ H, Wang Z, Jiang H.

J Cell Biochem. 2012 Dec;113(12):3672-80. doi: 10.1002/jcb.24240.


Berberine promotes bone marrow-derived mesenchymal stem cells osteogenic differentiation via canonical Wnt/β-catenin signaling pathway.

Tao K, Xiao D, Weng J, Xiong A, Kang B, Zeng H.

Toxicol Lett. 2016 Jan 5;240(1):68-80. doi: 10.1016/j.toxlet.2015.10.007. Epub 2015 Oct 22.


Repairing critical-sized calvarial defects with BMSCs modified by a constitutively active form of hypoxia-inducible factor-1α and a phosphate cement scaffold.

Zou D, Zhang Z, He J, Zhu S, Wang S, Zhang W, Zhou J, Xu Y, Huang Y, Wang Y, Han W, Zhou Y, Wang S, You S, Jiang X, Huang Y.

Biomaterials. 2011 Dec;32(36):9707-18. doi: 10.1016/j.biomaterials.2011.09.005. Epub 2011 Oct 4.


Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors.

Aprelikova O, Chandramouli GV, Wood M, Vasselli JR, Riss J, Maranchie JK, Linehan WM, Barrett JC.

J Cell Biochem. 2004 Jun 1;92(3):491-501. Erratum in: J Cell Biochem. 2004 Oct 15;93(3):639.


Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].

Stolze IP, Tian YM, Appelhoff RJ, Turley H, Wykoff CC, Gleadle JM, Ratcliffe PJ.

J Biol Chem. 2004 Oct 8;279(41):42719-25. Epub 2004 Aug 9. Erratum in: J Biol Chem. 2004 Dec 24;279(52):54974.


In vitro mineralization of human mesenchymal stem cells on three-dimensional type I collagen versus PLGA scaffolds: a comparative analysis.

Kruger EA, Im DD, Bischoff DS, Pereira CT, Huang W, Rudkin GH, Yamaguchi DT, Miller TA.

Plast Reconstr Surg. 2011 Jun;127(6):2301-11. doi: 10.1097/PRS.0b013e318213a004.


Modulation of Bone-Specific Tissue Regeneration by Incorporating Bone Morphogenetic Protein and Controlling the Shell Thickness of Silk Fibroin/Chitosan/Nanohydroxyapatite Core-Shell Nanofibrous Membranes.

Shalumon KT, Lai GJ, Chen CH, Chen JP.

ACS Appl Mater Interfaces. 2015 Sep 30;7(38):21170-81. doi: 10.1021/acsami.5b04962. Epub 2015 Sep 18.


Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury.

Natarajan R, Salloum FN, Fisher BJ, Kukreja RC, Fowler AA 3rd.

Circ Res. 2006 Jan 6;98(1):133-40. Epub 2005 Nov 23.


Short hairpin RNA interference therapy for ischemic heart disease.

Huang M, Chan DA, Jia F, Xie X, Li Z, Hoyt G, Robbins RC, Chen X, Giaccia AJ, Wu JC.

Circulation. 2008 Sep 30;118(14 Suppl):S226-33. doi: 10.1161/CIRCULATIONAHA.107.760785.


Mesenchymal stem cell function on hybrid organic/inorganic microparticles in vitro.

Jayasuriya AC, Bhat A.

J Tissue Eng Regen Med. 2010 Jul;4(5):340-8. doi: 10.1002/term.244.


Prolyl hydroxylase 2 deficiency limits proliferation of vascular smooth muscle cells by hypoxia-inducible factor-1{alpha}-dependent mechanisms.

Schultz K, Murthy V, Tatro JB, Beasley D.

Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L921-7. doi: 10.1152/ajplung.90393.2008. Epub 2009 Mar 20.


Topical prolyl hydroxylase domain-2 silencing improves diabetic murine wound closure.

Wetterau M, George F, Weinstein A, Nguyen PD, Tutela JP, Knobel D, Cohen Ba O, Warren SM, Saadeh PB.

Wound Repair Regen. 2011 Jul-Aug;19(4):481-6. doi: 10.1111/j.1524-475X.2011.00697.x. Epub 2011 May 31.


Temporal expression of Pelp1 during proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells.

Wang J, Qiang Z, Song S, Shi L, Ma C, Tan X, Yin D, Niu Z.

PLoS One. 2013 Oct 16;8(10):e75477. doi: 10.1371/journal.pone.0075477. eCollection 2013. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/5fa9cfb4-9964-4586-845d-d8205f318d68. PLoS One. 2013;8(12). doi:10.1371/annotation/b5254278-c64f-40e1-90a8-de2ac7ffc001. Zhu, Qiang [corrected to Qiang, Zhu]. PLoS One. 2014;9(2):e90259. Ding, Yin [corrected to Yin, Ding].


Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells.

Yang HY, Vonk LA, Licht R, van Boxtel AM, Bekkers JE, Kragten AH, Hein S, Varghese OP, Howard KA, Öner FC, Dhert WJ, Creemers LB.

Eur J Pharm Sci. 2014 Mar 12;53:35-44. doi: 10.1016/j.ejps.2013.12.006. Epub 2013 Dec 15.


HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia.

Berra E, Benizri E, Ginouvès A, Volmat V, Roux D, Pouysségur J.

EMBO J. 2003 Aug 15;22(16):4082-90.


Conditional disruption of the prolyl hydroxylase domain-containing protein 2 (Phd2) gene defines its key role in skeletal development.

Cheng S, Xing W, Pourteymoor S, Mohan S.

J Bone Miner Res. 2014 Oct;29(10):2276-86. doi: 10.1002/jbmr.2258.


Superior osteogenic capacity of different mesenchymal stem cells for bone tissue engineering.

Wen Y, Jiang B, Cui J, Li G, Yu M, Wang F, Zhang G, Nan X, Yue W, Xu X, Pei X.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Nov;116(5):e324-32. doi: 10.1016/j.oooo.2012.02.024. Epub 2012 Jul 26.


The osteogenic properties of CaP/silk composite scaffolds.

Zhang Y, Wu C, Friis T, Xiao Y.

Biomaterials. 2010 Apr;31(10):2848-56. doi: 10.1016/j.biomaterials.2009.12.049. Epub 2010 Jan 13.


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