Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 59

1.

Casting a wider net: whole-cell assays to capture varied and biased signaling.

Kenakin T.

Mol Pharmacol. 2012 Oct;82(4):571-4. Epub 2012 Jul 24.

2.

Discovery of regulators of receptor internalization with high-throughput flow cytometry.

Wu Y, Tapia PH, Fisher GW, Simons PC, Strouse JJ, Foutz T, Waggoner AS, Jarvik J, Sklar LA.

Mol Pharmacol. 2012 Oct;82(4):645-57. Epub 2012 Jul 5.

3.

The role of conformational ensembles of seven transmembrane receptors in functional selectivity.

Vaidehi N, Kenakin T.

Curr Opin Pharmacol. 2010 Dec;10(6):775-81. doi: 10.1016/j.coph.2010.09.004. Review.

PMID:
20933468
4.

Resonant waveguide grating biosensor for whole-cell GPCR assays.

Fang Y, Ferrie AM, Tran E.

Methods Mol Biol. 2009;552:239-52. doi: 10.1007/978-1-60327-317-6_17.

PMID:
19513654
5.

Functional selectivity of GPCR ligand stereoisomers: new pharmacological opportunities.

Seifert R, Dove S.

Mol Pharmacol. 2009 Jan;75(1):13-8. doi: 10.1124/mol.108.052944. Epub 2008 Nov 10.

6.

High-throughput analysis of ligand-induced internalization of β2-adrenoceptors using the coiled-coil tag-probe method.

Takeda Y, Yano Y, Matsuzaki K.

Anal Chem. 2012 Feb 7;84(3):1754-9. doi: 10.1021/ac203231n. Epub 2012 Jan 30.

PMID:
22243418
7.

Monitoring ligand-mediated internalization of G protein-coupled receptor as a novel pharmacological approach.

Fukunaga S, Setoguchi S, Hirasawa A, Tsujimoto G.

Life Sci. 2006 Dec 3;80(1):17-23. Epub 2006 Aug 25.

PMID:
16978657
8.

Duplexed label-free G protein--coupled receptor assays for high-throughput screening.

Tran E, Ye Fang.

J Biomol Screen. 2008 Dec;13(10):975-85. doi: 10.1177/1087057108326141. Epub 2008 Nov 21.

PMID:
19029014
9.

A high-content subtractive screen for selecting small molecules affecting internalization of GPCRs.

Kwon YJ, Lee W, Genovesio A, Emans N.

J Biomol Screen. 2012 Mar;17(3):379-85. doi: 10.1177/1087057111427347. Epub 2011 Nov 15.

PMID:
22086721
10.

Cell-based high-throughput screening assay system for monitoring G protein-coupled receptor activation using beta-galactosidase enzyme complementation technology.

Yan YX, Boldt-Houle DM, Tillotson BP, Gee MA, D'Eon BJ, Chang XJ, Olesen CE, Palmer MA.

J Biomol Screen. 2002 Oct;7(5):451-9.

PMID:
14599361
11.

High throughput screening (HTS) in identification new ligands and drugable targets of G protein-coupled receptors (GPCRs).

Wang D, Li Y, Zhang Y, Liu Y, Shi G.

Comb Chem High Throughput Screen. 2012 Mar;15(3):232-41. Review.

PMID:
22221056
12.

Relationship between the G protein signaling and homologous desensitization of G protein-coupled receptors.

Barak LS, Gilchrist J, Becker JM, Kim KM.

Biochem Biophys Res Commun. 2006 Jan 13;339(2):695-700.

PMID:
16325780
13.

High throughput screening methodologies classified for major drug target classes according to target signaling pathways.

Kool J, Lingeman H, Niessen W, Irth H.

Comb Chem High Throughput Screen. 2010 Jul;13(6):548-61. Review.

PMID:
20429869
14.
15.

New strategies in drug discovery for GPCRs: high throughput detection of cellular ERK phosphorylation.

Crouch MF, Osmond RI.

Comb Chem High Throughput Screen. 2008 Jun;11(5):344-56.

PMID:
18537556
16.

Restructuring G-protein- coupled receptor activation.

Audet M, Bouvier M.

Cell. 2012 Sep 28;151(1):14-23. doi: 10.1016/j.cell.2012.09.003. Review.

17.

Profiling of toxicity and identification of distinct apoptosis profiles using a 384-well high-throughput flow cytometry screening platform.

Luu YK, Rana P, Duensing TD, Black C, Will Y.

J Biomol Screen. 2012 Jul;17(6):806-12. doi: 10.1177/1087057112441205. Epub 2012 Apr 6.

PMID:
22496094
18.

A novel enzyme complementation-based assay for monitoring G-protein-coupled receptor internalization.

Hammer MM, Wehrman TS, Blau HM.

FASEB J. 2007 Dec;21(14):3827-34. Epub 2007 Oct 17.

PMID:
17942829
19.

Label-free biosensor assays in GPCR screening.

Grundmann M, Kostenis E.

Methods Mol Biol. 2015;1272:199-213. doi: 10.1007/978-1-4939-2336-6_14.

PMID:
25563186
20.

Biased ligands for better cardiovascular drugs: dissecting G-protein-coupled receptor pharmacology.

DeWire SM, Violin JD.

Circ Res. 2011 Jul 8;109(2):205-16. doi: 10.1161/CIRCRESAHA.110.231308. Review.

Supplemental Content

Support Center