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Items: 1 to 20 of 135

1.

Synergistic effects of nelfinavir and bortezomib on proteotoxic death of NSCLC and multiple myeloma cells.

Kawabata S, Gills JJ, Mercado-Matos JR, Lopiccolo J, Wilson W 3rd, Hollander MC, Dennis PA.

Cell Death Dis. 2012 Jul 19;3:e353. doi: 10.1038/cddis.2012.87.

2.

PKCδ regulates death receptor 5 expression induced by PS-341 through ATF4-ATF3/CHOP axis in human lung cancer cells.

Xu L, Su L, Liu X.

Mol Cancer Ther. 2012 Oct;11(10):2174-82. doi: 10.1158/1535-7163.MCT-12-0602. Epub 2012 Jul 30.

3.

Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo.

Escalante AM, McGrath RT, Karolak MR, Dorr RT, Lynch RM, Landowski TH.

Cancer Chemother Pharmacol. 2013 Jun;71(6):1567-76. doi: 10.1007/s00280-013-2156-3. Epub 2013 Apr 10.

4.

Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells.

Moriya S, Che XF, Komatsu S, Abe A, Kawaguchi T, Gotoh A, Inazu M, Tomoda A, Miyazawa K.

Int J Oncol. 2013 May;42(5):1541-50. doi: 10.3892/ijo.2013.1870. Epub 2013 Mar 28.

5.

Targeting the integrated networks of aggresome formation, proteasome, and autophagy potentiates ER stress‑mediated cell death in multiple myeloma cells.

Moriya S, Komatsu S, Yamasaki K, Kawai Y, Kokuba H, Hirota A, Che XF, Inazu M, Gotoh A, Hiramoto M, Miyazawa K.

Int J Oncol. 2015 Feb;46(2):474-86. doi: 10.3892/ijo.2014.2773. Epub 2014 Nov 24.

6.

Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells.

Nawrocki ST, Carew JS, Dunner K Jr, Boise LH, Chiao PJ, Huang P, Abbruzzese JL, McConkey DJ.

Cancer Res. 2005 Dec 15;65(24):11510-9.

7.

Combined treatment with bortezomib plus bafilomycin A1 enhances the cytocidal effect and induces endoplasmic reticulum stress in U266 myeloma cells: crosstalk among proteasome, autophagy-lysosome and ER stress.

Kawaguchi T, Miyazawa K, Moriya S, Ohtomo T, Che XF, Naito M, Itoh M, Tomoda A.

Int J Oncol. 2011 Mar;38(3):643-54. doi: 10.3892/ijo.2010.882. Epub 2010 Dec 21.

PMID:
21174067
8.

Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6.

Guan M, Fousek K, Jiang C, Guo S, Synold T, Xi B, Shih CC, Chow WA.

Clin Cancer Res. 2011 Apr 1;17(7):1796-806. doi: 10.1158/1078-0432.CCR-10-3216. Epub 2011 Feb 25.

9.

The human immunodeficiency virus-1 protease inhibitor nelfinavir impairs proteasome activity and inhibits the proliferation of multiple myeloma cells in vitro and in vivo.

Bono C, Karlin L, Harel S, Mouly E, Labaume S, Galicier L, Apcher S, Sauvageon H, Fermand JP, Bories JC, Arnulf B.

Haematologica. 2012 Jul;97(7):1101-9. doi: 10.3324/haematol.2011.049981. Epub 2012 Jan 22.

10.

NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines.

Yang Y, Ikezoe T, Nishioka C, Bandobashi K, Takeuchi T, Adachi Y, Kobayashi M, Takeuchi S, Koeffler HP, Taguchi H.

Br J Cancer. 2006 Dec 18;95(12):1653-62. Epub 2006 Nov 28.

11.

Activating transcription factor 4, an ER stress mediator, is required for, but excessive ER stress suppresses osteoblastogenesis by bortezomib.

Nakamura S, Miki H, Kido S, Nakano A, Hiasa M, Oda A, Amou H, Watanabe K, Harada T, Fujii S, Takeuchi K, Kagawa K, Ozaki S, Matsumoto T, Abe M.

Int J Hematol. 2013 Jul;98(1):66-73. doi: 10.1007/s12185-013-1367-z. Epub 2013 May 25.

PMID:
23708974
12.

Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.

Nawrocki ST, Carew JS, Maclean KH, Courage JF, Huang P, Houghton JA, Cleveland JL, Giles FJ, McConkey DJ.

Blood. 2008 Oct 1;112(7):2917-26. doi: 10.1182/blood-2007-12-130823. Epub 2008 Jul 18.

13.

Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells.

Obeng EA, Carlson LM, Gutman DM, Harrington WJ Jr, Lee KP, Boise LH.

Blood. 2006 Jun 15;107(12):4907-16. Epub 2006 Feb 28.

14.

Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma.

Chauhan D, Singh A, Brahmandam M, Podar K, Hideshima T, Richardson P, Munshi N, Palladino MA, Anderson KC.

Blood. 2008 Feb 1;111(3):1654-64. Epub 2007 Nov 15.

15.

Bortezomib/proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells.

Selimovic D, Porzig BB, El-Khattouti A, Badura HE, Ahmad M, Ghanjati F, Santourlidis S, Haikel Y, Hassan M.

Cell Signal. 2013 Jan;25(1):308-18. doi: 10.1016/j.cellsig.2012.10.004. Epub 2012 Oct 15. Erratum in: Cell Signal. 2015 Mar;27(3):727. Cell Signal. 2015 May;27(5):1019-1020.

PMID:
23079083
16.

Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation.

Brüning A, Rahmeh M, Friese K.

Mol Oncol. 2013 Dec;7(6):1012-8. doi: 10.1016/j.molonc.2013.07.010. Epub 2013 Jul 20.

17.

Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.

Mimura N, Fulciniti M, Gorgun G, Tai YT, Cirstea D, Santo L, Hu Y, Fabre C, Minami J, Ohguchi H, Kiziltepe T, Ikeda H, Kawano Y, French M, Blumenthal M, Tam V, Kertesz NL, Malyankar UM, Hokenson M, Pham T, Zeng Q, Patterson JB, Richardson PG, Munshi NC, Anderson KC.

Blood. 2012 Jun 14;119(24):5772-81. doi: 10.1182/blood-2011-07-366633. Epub 2012 Apr 26.

18.

Reovirus therapy stimulates endoplasmic reticular stress, NOXA induction, and augments bortezomib-mediated apoptosis in multiple myeloma.

Kelly KR, Espitia CM, Mahalingam D, Oyajobi BO, Coffey M, Giles FJ, Carew JS, Nawrocki ST.

Oncogene. 2012 Jun 21;31(25):3023-38. doi: 10.1038/onc.2011.478. Epub 2011 Oct 17.

PMID:
22002308
19.

Panobinostat synergizes with bortezomib to induce endoplasmic reticulum stress and ubiquitinated protein accumulation in renal cancer cells.

Sato A, Asano T, Isono M, Ito K, Asano T.

BMC Urol. 2014 Aug 30;14:71. doi: 10.1186/1471-2490-14-71.

20.

Combined therapeutic effects of bortezomib and anacardic acid on multiple myeloma cells via activation of the endoplasmic reticulum stress response.

Dong X, Liao Y, Liu N, Hua X, Cai J, Liu J, Huang H.

Mol Med Rep. 2016 Sep;14(3):2679-84. doi: 10.3892/mmr.2016.5533. Epub 2016 Jul 19.

PMID:
27430733

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