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Items: 1 to 20 of 115

1.

Allosteric inhibition of the DNA-dependent ATPase activity of Escherichia coli DNA gyrase by a representative of a novel class of inhibitors.

Shapiro AB, Andrews B.

Biochem Pharmacol. 2012 Oct 1;84(7):900-4. doi: 10.1016/j.bcp.2012.07.007. Epub 2012 Jul 20.

PMID:
22820247
2.

Effect of different classes of inhibitors on DNA gyrase from Mycobacterium smegmatis.

Chatterji M, Unniraman S, Mahadevan S, Nagaraja V.

J Antimicrob Chemother. 2001 Oct;48(4):479-85.

PMID:
11581225
3.

Streptococcus pneumononiae gyrase ATPase: development and validation of an assay for inhibitor discovery and characterization.

Miller JR, Herberg JT, Tomilo M, McCroskey MC, Feilmeier BJ.

Anal Biochem. 2007 Jun 1;365(1):132-43. Epub 2007 Feb 27.

PMID:
17395144
4.

Evidence for the role of DNA strand passage in the mechanism of action of microcin B17 on DNA gyrase.

Pierrat OA, Maxwell A.

Biochemistry. 2005 Mar 22;44(11):4204-15.

PMID:
15766248
5.

Discovery and development of ATPase inhibitors of DNA gyrase as antibacterial agents.

Oblak M, Kotnik M, Solmajer T.

Curr Med Chem. 2007;14(19):2033-47. Review.

PMID:
17691945
6.

Active-site residues of Escherichia coli DNA gyrase required in coupling ATP hydrolysis to DNA supercoiling and amino acid substitutions leading to novobiocin resistance.

Gross CH, Parsons JD, Grossman TH, Charifson PS, Bellon S, Jernee J, Dwyer M, Chambers SP, Markland W, Botfield M, Raybuck SA.

Antimicrob Agents Chemother. 2003 Mar;47(3):1037-46.

7.

A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism.

Manjunatha UH, Maxwell A, Nagaraja V.

Nucleic Acids Res. 2005 Jun 1;33(10):3085-94. Print 2005.

8.

Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.

Ronkin SM, Badia M, Bellon S, Grillot AL, Gross CH, Grossman TH, Mani N, Parsons JD, Stamos D, Trudeau M, Wei Y, Charifson PS.

Bioorg Med Chem Lett. 2010 May 1;20(9):2828-31. doi: 10.1016/j.bmcl.2010.03.052. Epub 2010 Mar 15.

PMID:
20356737
9.

Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases.

Black MT, Stachyra T, Platel D, Girard AM, Claudon M, Bruneau JM, Miossec C.

Antimicrob Agents Chemother. 2008 Sep;52(9):3339-49. doi: 10.1128/AAC.00496-08. Epub 2008 Jul 14.

10.

A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase.

Edwards MJ, Flatman RH, Mitchenall LA, Stevenson CE, Le TB, Clarke TA, McKay AR, Fiedler HP, Buttner MJ, Lawson DM, Maxwell A.

Science. 2009 Dec 4;326(5958):1415-8. doi: 10.1126/science.1179123.

11.

Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives.

Liu XH, Cui P, Song BA, Bhadury PS, Zhu HL, Wang SF.

Bioorg Med Chem. 2008 Apr 1;16(7):4075-82. doi: 10.1016/j.bmc.2008.01.035. Epub 2008 Jan 29.

PMID:
18262793
12.

Mechanism of inhibition of DNA gyrase by ES-1273, a novel DNA gyrase inhibitor.

Oyamada Y, Yamagishi J, Kihara T, Yoshida H, Wachi M, Ito H.

Microbiol Immunol. 2007;51(10):977-84.

13.

Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV.

Manchester JI, Dussault DD, Rose JA, Boriack-Sjodin PA, Uria-Nickelsen M, Ioannidis G, Bist S, Fleming P, Hull KG.

Bioorg Med Chem Lett. 2012 Aug 1;22(15):5150-6. doi: 10.1016/j.bmcl.2012.05.128. Epub 2012 Jun 19.

PMID:
22814212
14.

The pentapeptide repeat proteins MfpAMt and QnrB4 exhibit opposite effects on DNA gyrase catalytic reactions and on the ternary gyrase-DNA-quinolone complex.

Mérens A, Matrat S, Aubry A, Lascols C, Jarlier V, Soussy CJ, Cavallo JD, Cambau E.

J Bacteriol. 2009 Mar;191(5):1587-94. doi: 10.1128/JB.01205-08. Epub 2008 Dec 5.

15.
16.

Mechanism of inhibition of DNA gyrase by cyclothialidine, a novel DNA gyrase inhibitor.

Nakada N, Gmünder H, Hirata T, Arisawa M.

Antimicrob Agents Chemother. 1994 Sep;38(9):1966-73.

17.

Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action.

Flatman RH, Howells AJ, Heide L, Fiedler HP, Maxwell A.

Antimicrob Agents Chemother. 2005 Mar;49(3):1093-100.

18.

Dimerization of Escherichia coli DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic center.

Brino L, Urzhumtsev A, Mousli M, Bronner C, Mitschler A, Oudet P, Moras D.

J Biol Chem. 2000 Mar 31;275(13):9468-75.

19.

Gyramides prevent bacterial growth by inhibiting DNA gyrase and altering chromosome topology.

Rajendram M, Hurley KA, Foss MH, Thornton KM, Moore JT, Shaw JT, Weibel DB.

ACS Chem Biol. 2014 Jun 20;9(6):1312-9. doi: 10.1021/cb500154m. Epub 2014 Apr 22.

20.

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