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Items: 1 to 20 of 98

1.

Identification of potential small molecule binding pockets on Rho family GTPases.

Ortiz-Sanchez JM, Nichols SE, Sayyah J, Brown JH, McCammon JA, Grant BJ.

PLoS One. 2012;7(7):e40809. doi: 10.1371/journal.pone.0040809. Epub 2012 Jul 16.

2.

Novel allosteric sites on Ras for lead generation.

Grant BJ, Lukman S, Hocker HJ, Sayyah J, Brown JH, McCammon JA, Gorfe AA.

PLoS One. 2011;6(10):e25711. doi: 10.1371/journal.pone.0025711. Epub 2011 Oct 25.

3.

X-ray crystal structures reveal two activated states for RhoC.

Dias SM, Cerione RA.

Biochemistry. 2007 Jun 5;46(22):6547-58. Epub 2007 May 12.

PMID:
17497936
4.

Tax-interacting protein 1 coordinates the spatiotemporal activation of Rho GTPases and regulates the infiltrative growth of human glioblastoma.

Wang H, Han M, Whetsell W Jr, Wang J, Rich J, Hallahan D, Han Z.

Oncogene. 2014 Mar 20;33(12):1558-69. doi: 10.1038/onc.2013.97. Epub 2013 Apr 8.

5.

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.

Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J.

Nat Struct Biol. 2002 Jun;9(6):468-75.

PMID:
12006984
6.

Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases.

Longenecker KL, Lewis ME, Chikumi H, Gutkind JS, Derewenda ZS.

Structure. 2001 Jul 3;9(7):559-69.

7.

Structural basis of the Rho GTPase signaling.

Hakoshima T, Shimizu T, Maesaki R.

J Biochem. 2003 Sep;134(3):327-31. Review.

8.

Transient pockets on XIAP-BIR2: toward the characterization of putative binding sites of small-molecule XIAP inhibitors.

Eyrisch S, Medina-Franco JL, Helms V.

J Mol Model. 2012 May;18(5):2031-42. doi: 10.1007/s00894-011-1217-y. Epub 2011 Aug 30.

PMID:
21877153
9.

Conformational selection in G-proteins: lessons from Ras and Rho.

Grant BJ, McCammon JA, Gorfe AA.

Biophys J. 2010 Dec 1;99(11):L87-9. doi: 10.1016/j.bpj.2010.10.020.

10.

Targeting rho GTPases by peptidic structures.

Marchioni F, Zheng Y.

Curr Pharm Des. 2009;15(21):2481-7. Review.

PMID:
19601845
11.
13.

Rho GTPases and their effector proteins.

Bishop AL, Hall A.

Biochem J. 2000 Jun 1;348 Pt 2:241-55. Review.

15.
16.

Structural Dynamics in Ras and Related Proteins upon Nucleotide Switching.

Harrison RA, Lu J, Carrasco M, Hunter J, Manandhar A, Gondi S, Westover KD, Engen JR.

J Mol Biol. 2016 Nov 20;428(23):4723-4735. doi: 10.1016/j.jmb.2016.10.017. Epub 2016 Oct 14.

PMID:
27751724
17.

The G protein-coupled receptor S1P2 regulates Rho/Rho kinase pathway to inhibit tumor cell migration.

Lepley D, Paik JH, Hla T, Ferrer F.

Cancer Res. 2005 May 1;65(9):3788-95.

18.

Structure-function based design of small molecule inhibitors targeting Rho family GTPases.

Nassar N, Cancelas J, Zheng J, Williams DA, Zheng Y.

Curr Top Med Chem. 2006;6(11):1109-16. Review.

PMID:
16842149
19.

In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion.

Hirata E, Yukinaga H, Kamioka Y, Arakawa Y, Miyamoto S, Okada T, Sahai E, Matsuda M.

J Cell Sci. 2012 Feb 15;125(Pt 4):858-68. doi: 10.1242/jcs.089995. Epub 2012 Mar 7.

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