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CD40 inhibits replication of hepatitis C virus in primary human hepatocytes by c-Jun N terminal kinase activation independent from the interferon pathway.

Rau SJ, Hildt E, Himmelsbach K, Thimme R, Wakita T, Blum HE, Fischer R.

Hepatology. 2013 Jan;57(1):23-36. doi: 10.1002/hep.25966.


Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells.

Plumlee CR, Lazaro CA, Fausto N, Polyak SJ.

Virol J. 2005 Dec 2;2:89.


ISG12a inhibits HCV replication and potentiates the anti-HCV activity of IFN-α through activation of the Jak/STAT signaling pathway independent of autophagy and apoptosis.

Chen Y, Jiao B, Yao M, Shi X, Zheng Z, Li S, Chen L.

Virus Res. 2017 Jan 2;227:231-239. doi: 10.1016/j.virusres.2016.10.013. Epub 2016 Oct 21.


Hepatitis C virus triggers apoptosis of a newly developed hepatoma cell line through antiviral defense system.

Zhu H, Dong H, Eksioglu E, Hemming A, Cao M, Crawford JM, Nelson DR, Liu C.

Gastroenterology. 2007 Nov;133(5):1649-59. Epub 2007 Sep 16.


CD8+ T-cell interaction with HCV replicon cells: evidence for both cytokine- and cell-mediated antiviral activity.

Liu C, Zhu H, Tu Z, Xu YL, Nelson DR.

Hepatology. 2003 Jun;37(6):1335-42.


HCV-induced miR-21 contributes to evasion of host immune system by targeting MyD88 and IRAK1.

Chen Y, Chen J, Wang H, Shi J, Wu K, Liu S, Liu Y, Wu J.

PLoS Pathog. 2013;9(4):e1003248. doi: 10.1371/journal.ppat.1003248. Epub 2013 Apr 25.


Hepatitis C virus replication in mouse cells is restricted by IFN-dependent and -independent mechanisms.

Nandakumar R, Finsterbusch K, Lipps C, Neumann B, Grashoff M, Nair S, Hochnadel I, Lienenklaus S, Wappler I, Steinmann E, Hauser H, Pietschmann T, Kröger A.

Gastroenterology. 2013 Dec;145(6):1414-23.e1. doi: 10.1053/j.gastro.2013.08.037. Epub 2013 Aug 21.


CD40 ligand-mediated activation of the de novo RelB NF-kappaB synthesis pathway in transformed B cells promotes rescue from apoptosis.

Mineva ND, Rothstein TL, Meyers JA, Lerner A, Sonenshein GE.

J Biol Chem. 2007 Jun 15;282(24):17475-85. Epub 2007 Apr 19.


CD56+ T cells inhibit hepatitis C virus replication in human hepatocytes.

Ye L, Wang X, Wang S, Wang Y, Song L, Hou W, Zhou L, Li H, Ho W.

Hepatology. 2009 Mar;49(3):753-62. doi: 10.1002/hep.22715.


1Hepatitis C virus NS5A protein modulates c-Jun N-terminal kinase through interaction with tumor necrosis factor receptor-associated factor 2.

Park KJ, Choi SH, Choi DH, Park JM, Yie SW, Lee SY, Hwang SB.

J Biol Chem. 2003 Aug 15;278(33):30711-8. Epub 2003 Jun 7.


Enhanced T cell responses against hepatitis C virus by ex vivo targeting of adenoviral particles to dendritic cells.

Echeverria I, Pereboev A, Silva L, Zabaleta A, Riezu-Boj JI, Bes M, Cubero M, Borras-Cuesta F, Lasarte JJ, Esteban JI, Prieto J, Sarobe P.

Hepatology. 2011 Jul;54(1):28-37. doi: 10.1002/hep.24325. Epub 2011 May 14.


Hepatitis C virus-infected hepatocytes extrinsically modulate dendritic cell maturation to activate T cells and natural killer cells.

Ebihara T, Shingai M, Matsumoto M, Wakita T, Seya T.

Hepatology. 2008 Jul;48(1):48-58. doi: 10.1002/hep.22337.


Modulation of Hepatitis C Virus-Specific CD8 Effector T-Cell Function with Antiviral Effect in Infectious Hepatitis C Virus Coculture Model.

Ojiro K, Qu X, Cho H, Park JJ, Vuidepot A, Lissin N, Molloy PE, Bennett A, Jakobsen BK, Kaplan DE, Riley JL, Chang KM.

J Virol. 2017 Apr 28;91(10). pii: e02129-16. doi: 10.1128/JVI.02129-16. Print 2017 May 15.


Analysis of CD8+ T-cell-mediated inhibition of hepatitis C virus replication using a novel immunological model.

Jo J, Aichele U, Kersting N, Klein R, Aichele P, Bisse E, Sewell AK, Blum HE, Bartenschlager R, Lohmann V, Thimme R.

Gastroenterology. 2009 Apr;136(4):1391-401. doi: 10.1053/j.gastro.2008.12.034. Epub 2008 Dec 13.


Altered expression and activation of signal transducers and activators of transcription (STATs) in hepatitis C virus infection: in vivo and in vitro studies.

Larrea E, Aldabe R, Molano E, Fernandez-Rodriguez CM, Ametzazurra A, Civeira MP, Prieto J.

Gut. 2006 Aug;55(8):1188-96. Epub 2005 Aug 24.


Hepatitis C virus inhibits intracellular interferon alpha expression in human hepatic cell lines.

Zhang T, Lin RT, Li Y, Douglas SD, Maxcey C, Ho C, Lai JP, Wang YJ, Wan Q, Ho WZ.

Hepatology. 2005 Oct;42(4):819-27.


Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes.

Stevenson NJ, Bourke NM, Ryan EJ, Binder M, Fanning L, Johnston JA, Hegarty JE, Long A, O'Farrelly C.

FEBS Lett. 2013 May 21;587(10):1571-8. doi: 10.1016/j.febslet.2013.03.041. Epub 2013 Apr 12.


Ribavirin enhances the action of interferon-α against hepatitis C virus by promoting the p53 activity through the ERK1/2 pathway.

Liu WL, Yang HC, Su WC, Wang CC, Chen HL, Wang HY, Huang WH, Chen DS, Lai MY.

PLoS One. 2012;7(9):e43824. doi: 10.1371/journal.pone.0043824. Epub 2012 Sep 4.

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