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Atorvastatin and simvastatin, but not pravastatin, up-regulate LPS-induced MMP-9 expression in macrophages by regulating phosphorylation of ERK and CREB.

Lee DK, Park EJ, Kim EK, Jin J, Kim JS, Shin IJ, Kim BY, Lee H, Kim DE.

Cell Physiol Biochem. 2012;30(3):499-511. doi: 10.1159/000341433.


Effects of statins on matrix metalloproteinases and their endogenous inhibitors in human endothelial cells.

Izidoro-Toledo TC, Guimaraes DA, Belo VA, Gerlach RF, Tanus-Santos JE.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Jun;383(6):547-54. doi: 10.1007/s00210-011-0623-0.


Atorvastatin suppresses LPS-induced rapid upregulation of Toll-like receptor 4 and its signaling pathway in endothelial cells.

Wang Y, Zhang MX, Meng X, Liu FQ, Yu GS, Zhang C, Sun T, Wang XP, Li L, Wang YY, Ding SF, Yang JM, Zhang Y.

Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1743-52. doi: 10.1152/ajpheart.01335.2008.


Statins inhibit cyclooxygenase-2 and matrix metalloproteinase-9 in human endothelial cells: anti-angiogenic actions possibly contributing to plaque stability.

Massaro M, Zampolli A, Scoditti E, Carluccio MA, Storelli C, Distante A, De Caterina R.

Cardiovasc Res. 2010 May 1;86(2):311-20. doi: 10.1093/cvr/cvp375.


Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract.

Kim SE, Thanh Thuy TT, Lee JH, Ro JY, Bae YA, Kong Y, Ahn JY, Lee DS, Oh YM, Lee SD, Lee YS.

Exp Mol Med. 2009 Apr 30;41(4):277-87. doi: 10.3858/emm.2009.41.4.031.


Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition: a role for RhoA in ABCA1-mediated cholesterol efflux.

Argmann CA, Edwards JY, Sawyez CG, O'Neil CH, Hegele RA, Pickering JG, Huff MW.

J Biol Chem. 2005 Jun 10;280(23):22212-21.


Effects of atorvastatin and pravastatin on signal transduction related to glucose uptake in 3T3L1 adipocytes.

Takaguri A, Satoh K, Itagaki M, Tokumitsu Y, Ichihara K.

J Pharmacol Sci. 2008 May;107(1):80-9.


Redox markers and inflammation are differentially affected by atorvastatin, pravastatin or simvastatin administered before endotoxin-induced acute lung injury.

Melo AC, Valença SS, Gitirana LB, Santos JC, Ribeiro ML, Machado MN, Magalhães CB, Zin WA, Porto LC.

Int Immunopharmacol. 2013 Sep;17(1):57-64. doi: 10.1016/j.intimp.2013.05.016.


HMG-CoA reductase inhibitors inhibit inducible nitric oxide synthase gene expression in macrophages.

Huang KC, Chen CW, Chen JC, Lin WW.

J Biomed Sci. 2003 Jul-Aug;10(4):396-405.


Simvastatin and atorvastatin attenuate VCAM-1 and uPAR expression on human endothelial cells and platelet surface expression of CD40 ligand.

Stach K, Nguyen XD, Lang S, Elmas E, Weiss C, Borggrefe M, Fischer J, Kälsch T.

Cardiol J. 2012;19(1):20-8.


Statin-induced expression of decay-accelerating factor protects vascular endothelium against complement-mediated injury.

Mason JC, Ahmed Z, Mankoff R, Lidington EA, Ahmad S, Bhatia V, Kinderlerer A, Randi AM, Haskard DO.

Circ Res. 2002 Oct 18;91(8):696-703.


Hydroxymethylglutaryl-coenzyme A reductase inhibitors induce apoptosis in human cardiac myocytes in vitro.

Demyanets S, Kaun C, Pfaffenberger S, Hohensinner PJ, Rega G, Pammer J, Maurer G, Huber K, Wojta J.

Biochem Pharmacol. 2006 Apr 28;71(9):1324-30.


Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia.

Bi X, Baudry M, Liu J, Yao Y, Fu L, Brucher F, Lynch G.

J Biol Chem. 2004 Nov 12;279(46):48238-45.


Statins (HMG-CoA reductase inhibitors) reduce CD40 expression in human vascular cells.

Mulhaupt F, Matter CM, Kwak BR, Pelli G, Veillard NR, Burger F, Graber P, Lüscher TF, Mach F.

Cardiovasc Res. 2003 Sep 1;59(3):755-66.


Statins upregulate cystathionine γ-lyase transcription and H2S generation via activating Akt signaling in macrophage.

Xu Y, Du HP, Li J, Xu R, Wang YL, You SJ, Liu H, Wang F, Cao YJ, Liu CF, Hu LF.

Pharmacol Res. 2014 Sep;87:18-25. doi: 10.1016/j.phrs.2014.06.006.


HMG-CoA reductase inhibitors, simvastatin and atorvastatin, downregulate ABCG1-mediated cholesterol efflux in human macrophages.

Wang W, Song W, Wang Y, Chen L, Yan X.

J Cardiovasc Pharmacol. 2013 Jul;62(1):90-8. doi: 10.1097/FJC.0b013e3182927e7c.


Atorvastatin inhibits angiotensin-converting enzyme induction in differentiating human macrophages.

Saijonmaa O, Nyman T, Fyhrquist F.

Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1917-21.

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