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Items: 1 to 20 of 110

1.

Reversal of dabigatran anticoagulation by prothrombin complex concentrate (Beriplex P/N) in a rabbit model.

Pragst I, Zeitler SH, Doerr B, Kaspereit FJ, Herzog E, Dickneite G, van Ryn J.

J Thromb Haemost. 2012 Sep;10(9):1841-8. doi: 10.1111/j.1538-7836.2012.04859.x.

2.

Thrombotic safety of prothrombin complex concentrate (Beriplex P/N) for dabigatran reversal in a rabbit model.

Herzog E, Kaspereit FJ, Krege W, Doerr B, van Ryn J, Dickneite G, Pragst I.

Thromb Res. 2014 Sep;134(3):729-36. doi: 10.1016/j.thromres.2014.07.003. Epub 2014 Jul 11.

3.

Reversal of dabigatran effects in models of thrombin generation and hemostasis by factor VIIa and prothrombin complex concentrate.

Hoffman M, Volovyk Z, Monroe DM.

Anesthesiology. 2015 Feb;122(2):353-62. doi: 10.1097/ALN.0000000000000540.

PMID:
25502064
4.

Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects.

Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M.

Circulation. 2011 Oct 4;124(14):1573-9. doi: 10.1161/CIRCULATIONAHA.111.029017. Epub 2011 Sep 6.

5.

Prothrombin complex concentrate (Beriplex P/N) for emergency anticoagulation reversal: a prospective multinational clinical trial.

Pabinger I, Brenner B, Kalina U, Knaub S, Nagy A, Ostermann H; Beriplex P/N Anticoagulation Reversal Study Group.

J Thromb Haemost. 2008 Apr;6(4):622-31. doi: 10.1111/j.1538-7836.2008.02904.x. Epub 2008 Jan 15.

6.

Prothrombin complex concentrates as reversal agents for new oral anticoagulants: lessons from preclinical studies with Beriplex.

Dickneite G.

Clin Lab Med. 2014 Sep;34(3):623-35. doi: 10.1016/j.cll.2014.06.001. Epub 2014 Jul 18. Review.

PMID:
25168947
7.

Prothrombin complex concentrate (Beriplex P/N) for control of bleeding after kidney trauma in a rabbit dilutional coagulopathy model.

Pragst I, Kaspereit F, Dörr B, Dickneite G.

Thromb Res. 2010 Mar;125(3):272-7. doi: 10.1016/j.thromres.2009.10.011. Epub 2009 Nov 14.

PMID:
19913880
8.

Successful emergency reversal of phenprocoumon anticoagulation with prothrombin complex concentrate: a prospective clinical study.

Lorenz R, Kienast J, Otto U, Kiehl M, Schreiter D, Haertel S, Barthels M.

Blood Coagul Fibrinolysis. 2007 Sep;18(6):565-70.

PMID:
17762533
9.

Prothrombin complex concentrate (Beriplex P/N) in severe bleeding: experience in a large tertiary hospital.

Bruce D, Nokes TJ.

Crit Care. 2008;12(4):R105. doi: 10.1186/cc6987. Epub 2008 Aug 15.

10.

Pharmacologic interventions for reversing the effects of oral anticoagulants.

Kalus JS.

Am J Health Syst Pharm. 2013 May 15;70(10 Suppl 1):S12-21. doi: 10.2146/ajhp130041.

PMID:
23640528
11.

Impact of infusion speed on the safety and effectiveness of prothrombin complex concentrate: a prospective clinical trial of emergency anticoagulation reversal.

Pabinger I, Tiede A, Kalina U, Knaub S, Germann R, Ostermann H; Beriplex P/N Anticoagulation Reversal Study Group.

Ann Hematol. 2010 Mar;89(3):309-16. doi: 10.1007/s00277-009-0830-7. Epub 2009 Sep 29.

PMID:
19787352
12.

Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study.

Sarode R, Milling TJ Jr, Refaai MA, Mangione A, Schneider A, Durn BL, Goldstein JN.

Circulation. 2013 Sep 10;128(11):1234-43. doi: 10.1161/CIRCULATIONAHA.113.002283. Epub 2013 Aug 9.

13.

Pharmacokinetics of Beriplex P/N prothrombin complex concentrate in healthy volunteers.

Ostermann H, Haertel S, Knaub S, Kalina U, Jung K, Pabinger I.

Thromb Haemost. 2007 Oct;98(4):790-7.

PMID:
17938803
14.

Warfarin-reversal: results of a phase III study with pasteurised, nanofiltrated prothrombin complex concentrate.

Pabinger-Fasching I.

Thromb Res. 2008;122 Suppl 2:S19-22. doi: 10.1016/S0049-3848(08)70005-7. Review.

PMID:
18549908
15.

Monitoring of dabigatran anticoagulation and its reversal in vitro by thrombelastography.

Solbeck S, Meyer MA, Johansson PI, Meyer AS, Cotton BA, Stensballe J, Schött U, Ostrowski SR.

Int J Cardiol. 2014 Oct 20;176(3):794-9. doi: 10.1016/j.ijcard.2014.07.084. Epub 2014 Aug 4.

PMID:
25156858
16.

Comparison of three-factor and four-factor prothrombin complex concentrates regarding reversal of the anticoagulant effects of rivaroxaban in healthy volunteers.

Levi M, Moore KT, Castillejos CF, Kubitza D, Berkowitz SD, Goldhaber SZ, Raghoebar M, Patel MR, Weitz JI, Levy JH.

J Thromb Haemost. 2014 Sep;12(9):1428-36. doi: 10.1111/jth.12599. Epub 2014 Jul 24.

17.

Long-term safety and efficacy of a pasteurized nanofiltrated prothrombin complex concentrate (Beriplex P/N): a pharmacovigilance study.

Hanke AA, Joch C, Görlinger K.

Br J Anaesth. 2013 May;110(5):764-72. doi: 10.1093/bja/aes501. Epub 2013 Jan 18. Review.

PMID:
23335567
19.

Dabigatran and its reversal with recombinant factor VIIa and prothrombin complex concentrate: a Sonoclot in vitro study.

Sølbeck S, Nilsson CU, Engström M, Ostrowski SR, Johansson PI.

Scand J Clin Lab Invest. 2014 Oct;74(7):591-8. doi: 10.3109/00365513.2014.921930. Epub 2014 Jun 9.

PMID:
24909158
20.

Four-factor prothrombin complex concentrate reverses apixaban-associated bleeding in a rabbit model of acute hemorrhage.

Herzog E, Kaspereit F, Krege W, Mueller-Cohrs J, Doerr B, Niebl P, Dickneite G.

J Thromb Haemost. 2015 Dec;13(12):2220-6. doi: 10.1111/jth.13165. Epub 2015 Nov 24.

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