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Items: 1 to 20 of 187

1.

Mouse-adapted H9N2 influenza A virus PB2 protein M147L and E627K mutations are critical for high virulence.

Wang J, Sun Y, Xu Q, Tan Y, Pu J, Yang H, Brown EG, Liu J.

PLoS One. 2012;7(7):e40752. doi: 10.1371/journal.pone.0040752. Epub 2012 Jul 10.

2.

Molecular basis of efficient replication and pathogenicity of H9N2 avian influenza viruses in mice.

Li X, Qi W, He J, Ning Z, Hu Y, Tian J, Jiao P, Xu C, Chen J, Richt J, Ma W, Liao M.

PLoS One. 2012;7(6):e40118. doi: 10.1371/journal.pone.0040118. Epub 2012 Jun 29.

3.

Rapid emergence of a PB2-E627K substitution confers a virulent phenotype to an H9N2 avian influenza virus during adoption in mice.

Sang X, Wang A, Chai T, He X, Ding J, Gao X, Li Y, Zhang K, Ren Z, Li L, Yu Z, Wang T, Feng N, Zheng X, Wang H, Zhao Y, Yang S, Gao Y, Xia X.

Arch Virol. 2015 May;160(5):1267-77. doi: 10.1007/s00705-015-2383-5. Epub 2015 Mar 19.

PMID:
25782865
4.

A nonpathogenic duck-origin H9N2 influenza A virus adapts to high pathogenicity in mice.

Liu Q, Chen H, Huang J, Chen Y, Gu M, Wang X, Hu S, Liu X, Liu X.

Arch Virol. 2014 Sep;159(9):2243-52. doi: 10.1007/s00705-014-2062-y. Epub 2014 Apr 3.

PMID:
24696271
5.

Molecular characterization of mammalian-adapted Korean-type avian H9N2 virus and evaluation of its virulence in mice.

Park KJ, Song MS, Kim EH, Kwon HI, Baek YH, Choi EH, Park SJ, Kim SM, Kim YI, Choi WS, Yoo DW, Kim CJ, Choi YK.

J Microbiol. 2015 Aug;53(8):570-7. doi: 10.1007/s12275-015-5329-4. Epub 2015 Jul 31.

PMID:
26224460
6.

Mutations during the Adaptation of H9N2 Avian Influenza Virus to the Respiratory Epithelium of Pigs Enhance Sialic Acid Binding Activity and Virulence in Mice.

Yang W, Punyadarsaniya D, Lambertz RL, Lee DC, Liang CH, Höper D, Leist SR, Hernández-Cáceres A, Stech J, Beer M, Wu CY, Wong CH, Schughart K, Meng F, Herrler G.

J Virol. 2017 Mar 29;91(8). pii: e02125-16. doi: 10.1128/JVI.02125-16. Print 2017 Apr 15.

PMID:
28148793
7.

PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza viruses.

Xiao C, Ma W, Sun N, Huang L, Li Y, Zeng Z, Wen Y, Zhang Z, Li H, Li Q, Yu Y, Zheng Y, Liu S, Hu P, Zhang X, Ning Z, Qi W, Liao M.

Sci Rep. 2016 Jan 19;6:19474. doi: 10.1038/srep19474.

8.

Virulence determinants in the PB2 gene of a mouse-adapted H9N2 virus.

Liu Q, Huang J, Chen Y, Chen H, Li Q, He L, Hao X, Liu J, Gu M, Hu J, Wang X, Hu S, Liu X, Liu X.

J Virol. 2015 Jan;89(1):877-82. doi: 10.1128/JVI.01775-14. Epub 2014 Oct 22.

9.

Single mutation at the amino acid position 627 of PB2 that leads to increased virulence of an H5N1 avian influenza virus during adaptation in mice can be compensated by multiple mutations at other sites of PB2.

Li J, Ishaq M, Prudence M, Xi X, Hu T, Liu Q, Guo D.

Virus Res. 2009 Sep;144(1-2):123-9. doi: 10.1016/j.virusres.2009.04.008. Epub 2009 Apr 23.

PMID:
19393699
10.

Adaptive mutations in PB2 gene contribute to the high virulence of a natural reassortant H5N2 avian influenza virus in mice.

Li Q, Wang X, Sun Z, Hu J, Gao Z, Hao X, Li J, Liu H, Wang X, Gu M, Xu X, Liu X, Liu X.

Virus Res. 2015 Dec 2;210:255-63. doi: 10.1016/j.virusres.2015.08.017. Epub 2015 Aug 24.

PMID:
26315686
11.

A combination of HA and PA mutations enhances virulence in a mouse-adapted H6N6 influenza A virus.

Tan L, Su S, Smith DK, He S, Zheng Y, Shao Z, Ma J, Zhu H, Zhang G.

J Virol. 2014 Dec;88(24):14116-25. doi: 10.1128/JVI.01736-14. Epub 2014 Oct 1.

12.

Effects of different polymerases of avian influenza viruses on the growth and pathogenicity of A/Puerto Rico/8/1934 (H1N1)-derived reassorted viruses.

Kim IH, Choi JG, Lee YJ, Kwon HJ, Kim JH.

Vet Microbiol. 2014 Jan 10;168(1):41-9. doi: 10.1016/j.vetmic.2013.10.011. Epub 2013 Oct 26.

PMID:
24296300
13.

Identification of potential virulence determinants associated H9N2 avian influenza virus PB2 E627K mutation by comparative proteomics.

Qi W, Tian J, Su S, Huang L, Li H, Liao M.

Proteomics. 2015 May;15(9):1512-24. doi: 10.1002/pmic.201400309. Epub 2015 Mar 11.

PMID:
25641917
14.

Assessment of the internal genes of influenza A (H7N9) virus contributing to high pathogenicity in mice.

Bi Y, Xie Q, Zhang S, Li Y, Xiao H, Jin T, Zheng W, Li J, Jia X, Sun L, Liu J, Qin C, Gao GF, Liu W.

J Virol. 2015 Jan;89(1):2-13. doi: 10.1128/JVI.02390-14. Epub 2014 Oct 15.

15.

Prevailing PA Mutation K356R in Avian Influenza H9N2 Virus Increases Mammalian Replication and Pathogenicity.

Xu G, Zhang X, Gao W, Wang C, Wang J, Sun H, Sun Y, Guo L, Zhang R, Chang KC, Liu J, Pu J.

J Virol. 2016 Aug 26;90(18):8105-14. doi: 10.1128/JVI.00883-16. Print 2016 Sep 15.

16.

Analysis of the phylogeny of Chinese H9N2 avian influenza viruses and their pathogenicity in mice.

Lin Z, Xu C, Liu B, Ji Y, Fu Y, Guo J, Zhu Q.

Arch Virol. 2014 Oct;159(10):2575-86. doi: 10.1007/s00705-014-2110-7. Epub 2014 May 17.

PMID:
24838853
17.

Multiple amino acid substitutions involved in enhanced pathogenicity of LPAI H9N2 in mice.

Zhang Z, Hu S, Li Z, Wang X, Liu M, Guo Z, Li S, Xiao Y, Bi D, Jin H.

Infect Genet Evol. 2011 Oct;11(7):1790-7. doi: 10.1016/j.meegid.2011.07.025. Epub 2011 Aug 27.

PMID:
21896338
18.

PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice.

Cheng K, Yu Z, Chai H, Sun W, Xin Y, Zhang Q, Huang J, Zhang K, Li X, Yang S, Wang T, Zheng X, Wang H, Qin C, Qian J, Chen H, Hua Y, Gao Y, Xia X.

Virology. 2014 Nov;468-470:207-13. doi: 10.1016/j.virol.2014.08.010. Epub 2014 Sep 6.

19.

Amino acid substitutions in polymerase basic protein 2 gene contribute to the pathogenicity of the novel A/H7N9 influenza virus in mammalian hosts.

Mok CK, Lee HH, Lestra M, Nicholls JM, Chan MC, Sia SF, Zhu H, Poon LL, Guan Y, Peiris JS.

J Virol. 2014 Mar;88(6):3568-76. doi: 10.1128/JVI.02740-13. Epub 2014 Jan 8.

20.

PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells.

Bussey KA, Bousse TL, Desmet EA, Kim B, Takimoto T.

J Virol. 2010 May;84(9):4395-406. doi: 10.1128/JVI.02642-09. Epub 2010 Feb 24.

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