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Items: 1 to 20 of 131

1.

Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides.

Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE.

Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12811-6. doi: 10.1073/pnas.1200330109. Epub 2012 Jul 16.

2.

Structural basis for olivetolic acid formation by a polyketide cyclase from Cannabis sativa.

Yang X, Matsui T, Kodama T, Mori T, Zhou X, Taura F, Noguchi H, Abe I, Morita H.

FEBS J. 2016 Mar;283(6):1088-106. doi: 10.1111/febs.13654. Epub 2016 Feb 2.

3.

Expression, purification and crystallization of a plant polyketide cyclase from Cannabis sativa.

Yang X, Matsui T, Mori T, Taura F, Noguchi H, Abe I, Morita H.

Acta Crystallogr F Struct Biol Commun. 2015 Dec;71(Pt 12):1470-4. doi: 10.1107/S2053230X15020385. Epub 2015 Nov 18.

PMID:
26625288
4.

Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathway.

Taura F, Tanaka S, Taguchi C, Fukamizu T, Tanaka H, Shoyama Y, Morimoto S.

FEBS Lett. 2009 Jun 18;583(12):2061-6. doi: 10.1016/j.febslet.2009.05.024. Epub 2009 May 19.

5.

PKS activities and biosynthesis of cannabinoids and flavonoids in Cannabis sativa L. plants.

Flores-Sanchez IJ, Verpoorte R.

Plant Cell Physiol. 2008 Dec;49(12):1767-82. doi: 10.1093/pcp/pcn150. Epub 2008 Oct 14.

PMID:
18854334
6.

The hexanoyl-CoA precursor for cannabinoid biosynthesis is formed by an acyl-activating enzyme in Cannabis sativa trichomes.

Stout JM, Boubakir Z, Ambrose SJ, Purves RW, Page JE.

Plant J. 2012 Aug;71(3):353-65. doi: 10.1111/j.1365-313X.2012.04949.x. Epub 2012 Jun 1.

7.

Identification of candidate genes affecting Delta9-tetrahydrocannabinol biosynthesis in Cannabis sativa.

Marks MD, Tian L, Wenger JP, Omburo SN, Soto-Fuentes W, He J, Gang DR, Weiblen GD, Dixon RA.

J Exp Bot. 2009;60(13):3715-26. doi: 10.1093/jxb/erp210. Epub 2009 Jul 6.

8.

The draft genome and transcriptome of Cannabis sativa.

van Bakel H, Stout JM, Cote AG, Tallon CM, Sharpe AG, Hughes TR, Page JE.

Genome Biol. 2011 Oct 20;12(10):R102. doi: 10.1186/gb-2011-12-10-r102.

9.

Cloning and over-expression of a cDNA encoding a polyketide synthase from Cannabis sativa.

Raharjo TJ, Chang WT, Verberne MC, Peltenburg-Looman AM, Linthorst HJ, Verpoorte R.

Plant Physiol Biochem. 2004 Apr;42(4):291-7.

PMID:
15120113
10.

Structural and biochemical characterization of ZhuI aromatase/cyclase from the R1128 polyketide pathway.

Ames BD, Lee MY, Moody C, Zhang W, Tang Y, Tsai SC.

Biochemistry. 2011 Oct 4;50(39):8392-406. doi: 10.1021/bi200593m. Epub 2011 Sep 8.

11.

Crystallization and preliminary X-ray diffraction studies of polyketide synthase-1 (PKS-1) from Cannabis sativa.

Taguchi C, Taura F, Tamada T, Shoyama Y, Shoyama Y, Tanaka H, Kuroki R, Morimoto S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Mar 1;64(Pt 3):217-20. doi: 10.1107/S1744309108003795. Epub 2008 Feb 29.

12.

Insights into natural products biosynthesis from analysis of 490 polyketide synthases from Fusarium.

Brown DW, Proctor RH.

Fungal Genet Biol. 2016 Apr;89:37-51. doi: 10.1016/j.fgb.2016.01.008. Epub 2016 Jan 27.

PMID:
26826610
13.

Rational reprogramming of fungal polyketide first-ring cyclization.

Xu Y, Zhou T, Zhou Z, Su S, Roberts SA, Montfort WR, Zeng J, Chen M, Zhang W, Lin M, Zhan J, Molnár I.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5398-403. doi: 10.1073/pnas.1301201110. Epub 2013 Mar 18.

14.

Monitoring Metabolite Profiles of Cannabis sativa L. Trichomes during Flowering Period Using 1H NMR-Based Metabolomics and Real-Time PCR.

Happyana N, Kayser O.

Planta Med. 2016 Aug;82(13):1217-23. doi: 10.1055/s-0042-108058. Epub 2016 Jun 23.

PMID:
27336318
15.

Structural basis for cyclization specificity of two Azotobacter type III polyketide synthases: a single amino acid substitution reverses their cyclization specificity.

Satou R, Miyanaga A, Ozawa H, Funa N, Katsuyama Y, Miyazono K, Tanokura M, Ohnishi Y, Horinouchi S.

J Biol Chem. 2013 Nov 22;288(47):34146-57. doi: 10.1074/jbc.M113.487272. Epub 2013 Oct 7.

16.

Iterative type II polyketide synthases, cyclases and ketoreductases exhibit context-dependent behavior in the biosynthesis of linear and angular decapolyketides.

Meurer G, Gerlitz M, Wendt-Pienkowski E, Vining LC, Rohr J, Hutchinson CR.

Chem Biol. 1997 Jun;4(6):433-43.

PMID:
9224566
17.

Type III polyketide synthases in natural product biosynthesis.

Yu D, Xu F, Zeng J, Zhan J.

IUBMB Life. 2012 Apr;64(4):285-95. doi: 10.1002/iub.1005. Epub 2012 Feb 23. Review.

18.

Molecular cloning, modeling, and site-directed mutagenesis of type III polyketide synthase from Sargassum binderi (Phaeophyta).

Baharum H, Morita H, Tomitsuka A, Lee FC, Ng KY, Rahim RA, Abe I, Ho CL.

Mar Biotechnol (NY). 2011 Oct;13(5):845-56. doi: 10.1007/s10126-010-9344-5. Epub 2010 Dec 23.

PMID:
21181422
19.

A new reducing polyketide synthase gene from the lichen-forming fungus Cladonia metacorallifera.

Kim JA, Hong SG, Cheong YH, Koh YJ, Hur JS.

Mycologia. 2012 Mar-Apr;104(2):362-70. doi: 10.3852/11-001. Epub 2012 Jan 5.

PMID:
22223171
20.

2-Alkylquinolone alkaloid biosynthesis in the medicinal plant Evodia rutaecarpa involves collaboration of two novel type III polyketide synthases.

Matsui T, Kodama T, Mori T, Tadakoshi T, Noguchi H, Abe I, Morita H.

J Biol Chem. 2017 Jun 2;292(22):9117-9135. doi: 10.1074/jbc.M117.778977. Epub 2017 Apr 14.

PMID:
28411241

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