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Items: 1 to 20 of 61

1.

Discovery of 1-[4-(N-benzylamino)phenyl]-3-phenylurea derivatives as non-peptidic selective SUMO-sentrin specific protease (SENP)1 inhibitors.

Uno M, Koma Y, Ban HS, Nakamura H.

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5169-73. doi: 10.1016/j.bmcl.2012.06.084. Epub 2012 Jul 3.

PMID:
22801642
2.

1-[4-(N-Benzylamino)phenyl]-3-phenylurea derivatives as a new class of hypoxia-inducible factor-1alpha inhibitors.

Uno M, Ban HS, Nakamura H.

Bioorg Med Chem Lett. 2009 Jun 15;19(12):3166-9. doi: 10.1016/j.bmcl.2009.04.122. Epub 2009 May 3.

PMID:
19435661
3.

2-(4-Chlorophenyl)-2-oxoethyl 4-benzamidobenzoate derivatives, a novel class of SENP1 inhibitors: Virtual screening, synthesis and biological evaluation.

Chen Y, Wen D, Huang Z, Huang M, Luo Y, Liu B, Lu H, Wu Y, Peng Y, Zhang J.

Bioorg Med Chem Lett. 2012 Nov 15;22(22):6867-70. doi: 10.1016/j.bmcl.2012.09.037. Epub 2012 Sep 20.

PMID:
23044371
4.

Boron-containing phenoxyacetanilide derivatives as hypoxia-inducible factor (HIF)-1alpha inhibitors.

Shimizu K, Maruyama M, Yasui Y, Minegishi H, Ban HS, Nakamura H.

Bioorg Med Chem Lett. 2010 Feb 15;20(4):1453-6. doi: 10.1016/j.bmcl.2009.12.037. Epub 2010 Jan 6.

PMID:
20083404
5.

Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives.

Domínguez JN, León C, Rodrigues J, Gamboa de Domínguez N, Gut J, Rosenthal PJ.

J Med Chem. 2005 May 19;48(10):3654-8.

PMID:
15887974
6.

Cell type-specific, topoisomerase II-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation by NSC 644221.

Creighton-Gutteridge M, Cardellina JH 2nd, Stephen AG, Rapisarda A, Uranchimeg B, Hite K, Denny WA, Shoemaker RH, Melillo G.

Clin Cancer Res. 2007 Feb 1;13(3):1010-8.

7.

Differential regulation of sentrinized proteins by a novel sentrin-specific protease.

Gong L, Millas S, Maul GG, Yeh ET.

J Biol Chem. 2000 Feb 4;275(5):3355-9.

8.

Design, synthesis and biological evaluation of novel L-lysine ureido derivatives as aminopeptidase N inhibitors.

Su L, Fang H, Yang K, Xu Y, Xu W.

Bioorg Med Chem. 2011 Jan 15;19(2):900-6. doi: 10.1016/j.bmc.2010.11.066. Epub 2010 Dec 4.

PMID:
21194957
9.

Suppression of hypoxia-induced HIF-1alpha accumulation by VEGFR inhibitors: Different profiles of AAL993 versus SU5416 and KRN633.

Ban HS, Uno M, Nakamura H.

Cancer Lett. 2010 Oct 1;296(1):17-26. doi: 10.1016/j.canlet.2010.03.010. Epub 2010 Apr 7.

PMID:
20378243
10.

The discovery of potent and selective 4-aminothienopyridines as B-Raf kinase inhibitors.

Tang J, Lackey KE, Dickerson SH.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):66-70. doi: 10.1016/j.bmcl.2012.11.020. Epub 2012 Nov 16.

PMID:
23218715
11.

Inhibition of VEGF transcription through blockade of the hypoxia inducible factor-1α-p300 interaction by a small molecule.

Kwon HS, Kim DR, Yang EG, Park YK, Ahn HC, Min SJ, Ahn DR.

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5249-52. doi: 10.1016/j.bmcl.2012.06.054. Epub 2012 Jun 23.

PMID:
22789427
12.

Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors.

Qiao Z, Wang W, Wang L, Wen D, Zhao Y, Wang Q, Meng Q, Chen G, Wu Y, Zhou H.

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6389-92. doi: 10.1016/j.bmcl.2011.08.101. Epub 2011 Sep 1.

PMID:
21930380
13.

Potent P1' biphenylmethyl substituted aggrecanase inhibitors.

Yao W, Chao M, Wasserman ZR, Liu RQ, Covington MB, Newton R, Christ D, Wexler RR, Decicco CP.

Bioorg Med Chem Lett. 2002 Jan 7;12(1):101-4.

PMID:
11738583
14.

SUMOylation of hypoxia-inducible factor-1alpha reduces its transcriptional activity.

Berta MA, Mazure N, Hattab M, Pouysségur J, Brahimi-Horn MC.

Biochem Biophys Res Commun. 2007 Aug 31;360(3):646-52. Epub 2007 Jun 27.

PMID:
17610843
15.

Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors.

Wang Z, Cuddy M, Samuel T, Welsh K, Schimmer A, Hanaii F, Houghten R, Pinilla C, Reed JC.

J Biol Chem. 2004 Nov 12;279(46):48168-76. Epub 2004 Aug 27.

16.

CCAAT/enhancer-binding protein alpha antagonizes transcriptional activity of hypoxia-inducible factor 1 alpha with direct protein-protein interaction.

Yang L, Jiang Y, Wu SF, Zhou MY, Wu YL, Chen GQ.

Carcinogenesis. 2008 Feb;29(2):291-8. Epub 2007 Nov 16.

PMID:
18024476
17.

SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors.

Xu Y, Li J, Zuo Y, Deng J, Wang LS, Chen GQ.

Cancer Lett. 2011 Oct 1;309(1):78-84. doi: 10.1016/j.canlet.2011.05.019. Epub 2011 Jun 12.

PMID:
21669491
18.

Development of small molecule inhibitors and probes of human SUMO deconjugating proteases.

Albrow VE, Ponder EL, Fasci D, Békés M, Deu E, Salvesen GS, Bogyo M.

Chem Biol. 2011 Jun 24;18(6):722-32. doi: 10.1016/j.chembiol.2011.05.008.

19.

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