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Triangulated mal-signaling in Alzheimer's disease: roles of neurotoxic ceramides, ER stress, and insulin resistance reviewed.

de la Monte SM.

J Alzheimers Dis. 2012;30 Suppl 2:S231-49. doi: 10.3233/JAD-2012-111727. Review.


Insulin resistance and neurodegeneration: roles of obesity, type 2 diabetes mellitus and non-alcoholic steatohepatitis.

de la Monte SM, Longato L, Tong M, Wands JR.

Curr Opin Investig Drugs. 2009 Oct;10(10):1049-60. Review.


Dysfunctional pro-ceramide, ER stress, and insulin/IGF signaling networks with progression of Alzheimer's disease.

de la Monte SM, Re E, Longato L, Tong M.

J Alzheimers Dis. 2012;30 Suppl 2:S217-29. doi: 10.3233/JAD-2012-111728.


Insulin resistance and Alzheimer's disease.

de la Monte SM.

BMB Rep. 2009 Aug 31;42(8):475-81. Review.


Ceramide-mediated insulin resistance and impairment of cognitive-motor functions.

de la Monte SM, Tong M, Nguyen V, Setshedi M, Longato L, Wands JR.

J Alzheimers Dis. 2010;21(3):967-84. doi: 10.3233/JAD-2010-091726.


Brain metabolic dysfunction at the core of Alzheimer's disease.

de la Monte SM, Tong M.

Biochem Pharmacol. 2014 Apr 15;88(4):548-59. doi: 10.1016/j.bcp.2013.12.012. Epub 2013 Dec 28. Review.


The liver-brain axis of alcohol-mediated neurodegeneration: role of toxic lipids.

de la Monte SM, Longato L, Tong M, DeNucci S, Wands JR.

Int J Environ Res Public Health. 2009 Jul;6(7):2055-75. doi: 10.3390/ijerph6072055. Epub 2009 Jul 23. Review.


Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis.

Lyn-Cook LE Jr, Lawton M, Tong M, Silbermann E, Longato L, Jiao P, Mark P, Wands JR, Xu H, de la Monte SM.

J Alzheimers Dis. 2009;16(4):715-29. doi: 10.3233/JAD-2009-0984.


Insulin resistance, ceramide accumulation, and endoplasmic reticulum stress in human chronic alcohol-related liver disease.

Longato L, Ripp K, Setshedi M, Dostalek M, Akhlaghi F, Branda M, Wands JR, de la Monte SM.

Oxid Med Cell Longev. 2012;2012:479348. doi: 10.1155/2012/479348. Epub 2012 Apr 22.


Insulin resistance, ceramide accumulation and endoplasmic reticulum stress in experimental chronic alcohol-induced steatohepatitis.

Ramirez T, Longato L, Dostalek M, Tong M, Wands JR, de la Monte SM.

Alcohol Alcohol. 2013 Jan-Feb;48(1):39-52. doi: 10.1093/alcalc/ags106. Epub 2012 Sep 20.


Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's disease.

de la Monte SM.

Drugs. 2012 Jan 1;72(1):49-66. doi: 10.2165/11597760-000000000-00000. Review.


Therapeutic reversal of chronic alcohol-related steatohepatitis with the ceramide inhibitor myriocin.

Tong M, Longato L, Ramirez T, Zabala V, Wands JR, de la Monte SM.

Int J Exp Pathol. 2014 Feb;95(1):49-63. doi: 10.1111/iep.12052. Epub 2013 Oct 29.


Insulin resistance and Alzheimer's disease: molecular links & clinical implications.

Neumann KF, Rojo L, Navarrete LP, Farías G, Reyes P, Maccioni RB.

Curr Alzheimer Res. 2008 Oct;5(5):438-47.


Mechanisms of ceramide-mediated neurodegeneration.

Tong M, de la Monte SM.

J Alzheimers Dis. 2009;16(4):705-14. doi: 10.3233/JAD-2009-0983.


Insulin resistance, inflammation, and cognition in Alzheimer's Disease: lessons for multiple sclerosis.

Watson GS, Craft S.

J Neurol Sci. 2006 Jun 15;245(1-2):21-33. Epub 2006 Apr 24. Review.


Alcohol, insulin resistance and the liver-brain axis.

de la Monte S, Derdak Z, Wands JR.

J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2:33-41. doi: 10.1111/j.1440-1746.2011.07023.x. Review.


Stress, the endoplasmic reticulum, and insulin resistance.

Tsiotra PC, Tsigos C.

Ann N Y Acad Sci. 2006 Nov;1083:63-76. Review.


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