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Items: 1 to 20 of 240

1.

New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms.

Carneiro PF, do Nascimento SB, Pinto AV, Pinto Mdo C, Lechuga GC, Santos DO, dos Santos Júnior HM, Resende JA, Bourguignon SC, Ferreira VF.

Bioorg Med Chem. 2012 Aug 15;20(16):4995-5000. doi: 10.1016/j.bmc.2012.06.027. Epub 2012 Jun 21.

PMID:
22795899
2.

Trypanosoma cruzi: activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms.

Salas C, Tapia RA, Ciudad K, Armstrong V, Orellana M, Kemmerling U, Ferreira J, Maya JD, Morello A.

Bioorg Med Chem. 2008 Jan 15;16(2):668-74. Epub 2007 Oct 18.

PMID:
18029184
3.

2-Phenylaminonaphthoquinones and related compounds: synthesis, trypanocidal and cytotoxic activities.

Sieveking I, Thomas P, Estévez JC, Quiñones N, Cuéllar MA, Villena J, Espinosa-Bustos C, Fierro A, Tapia RA, Maya JD, López-Muñoz R, Cassels BK, Estévez RJ, Salas CO.

Bioorg Med Chem. 2014 Sep 1;22(17):4609-20. doi: 10.1016/j.bmc.2014.07.030. Epub 2014 Jul 27.

PMID:
25127463
4.

Trypanosoma cruzi: in vitro activity of Epoxy-alpha-Lap, a derivative of alpha-lapachone, on trypomastigote and amastigote forms.

Bourguignon SC, Castro HC, Santos DO, Alves CR, Ferreira VF, Gama IL, Silva FC, Seguins WS, Pinho RT.

Exp Parasitol. 2009 Jun;122(2):91-6. doi: 10.1016/j.exppara.2009.03.002. Epub 2009 Mar 11.

PMID:
19285074
5.

In vitro and in vivo trypanocidal evaluation of nickel complexes with an azapurine derivative against Trypanosoma cruzi.

Maldonado CR, Marín C, Olmo F, Huertas O, Quirós M, Sánchez-Moreno M, Rosales MJ, Salas JM.

J Med Chem. 2010 Oct 14;53(19):6964-72. doi: 10.1021/jm100581z.

PMID:
20812723
6.

Naphthoquinoidal [1,2,3]-triazole, a new structural moiety active against Trypanosoma cruzi.

da Silva EN Jr, Menna-Barreto RF, Pinto Mdo C, Silva RS, Teixeira DV, de Souza MC, De Simone CA, De Castro SL, Ferreira VF, Pinto AV.

Eur J Med Chem. 2008 Aug;43(8):1774-80. Epub 2007 Oct 22.

PMID:
18045742
7.

Oxyrane derivative of alpha-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms.

Jorqueira A, Gouvêa RM, Ferreira VF, da Silva MN, de Souza MC, Zuma AA, Cavalcanti DF, Araújo HP, Santos DO, Bourguignon SC.

Parasitol Res. 2006 Sep;99(4):429-33. Epub 2006 Apr 5.

PMID:
16596415
8.

Effect of 9-hydroxy-α- and 7-hydroxy-β-pyran naphthoquinones on Trypanosoma cruzi and structure-activity relationship studies.

da Rochaa DR, de Souza AM, de Souza AC, Castro HC, Rodrigues CR, Menna-Barreto RF, de Castro SL, Ferreira VF.

Med Chem. 2014;10(6):564-70.

PMID:
24372389
9.

Synthesis, physicochemical properties of allopurinol derivatives and their biological activity against Trypanosoma cruzi.

Raviolo MA, Solana ME, Novoa MM, Gualdesi MS, Alba-Soto CD, Briñón MC.

Eur J Med Chem. 2013 Nov;69:455-64. doi: 10.1016/j.ejmech.2013.08.045. Epub 2013 Sep 13.

PMID:
24090917
10.

Synthesis of naphthofuranquinones with activity against Trypanosoma cruzi.

Silva RS, Costa EM, Trindade UL, Teixeira DV, Pinto Mde C, Santos GL, Malta VR, De Simone CA, Pinto AV, de Castro SL.

Eur J Med Chem. 2006 Apr;41(4):526-30. Epub 2006 Feb 28.

PMID:
16500733
11.

Natural and synthetic naphthoquinones active against Trypanosoma cruzi: an initial step towards new drugs for Chagas disease.

Salas CO, Faúndez M, Morello A, Maya JD, Tapia RA.

Curr Med Chem. 2011;18(1):144-61. Review.

PMID:
21110810
12.

Toxic effects of natural piperine and its derivatives on epimastigotes and amastigotes of Trypanosoma cruzi.

Ribeiro TS, Freire-de-Lima L, Previato JO, Mendonça-Previato L, Heise N, de Lima ME.

Bioorg Med Chem Lett. 2004 Jul 5;14(13):3555-8.

PMID:
15177472
13.

Trypanocidal agents with low cytotoxicity to mammalian cell line: a comparison of the theoretical and biological features of lapachone derivatives.

Ferreira VF, Jorqueira A, Souza AM, da Silva MN, de Souza MC, Gouvêa RM, Rodrigues CR, Pinto AV, Castro HC, Santos DO, Araújo HP, Bourguignon SC.

Bioorg Med Chem. 2006 Aug 15;14(16):5459-66. Epub 2006 May 24.

PMID:
16725327
14.

Synthesis and biological activity against Trypanosoma cruzi of substituted 1,4-naphthoquinones.

Olímpio da Silva A, da Silva Lopes R, Vieira de Lima R, Santos Suniga Tozatti C, Marques MR, de Albuquerque S, Beatriz A, Pires de Lima D.

Eur J Med Chem. 2013 Feb;60:51-6. doi: 10.1016/j.ejmech.2012.11.034. Epub 2012 Dec 1.

PMID:
23279867
15.

Activity of "reversed" diamidines against Trypanosoma cruzi "in vitro".

Silva CF, Batista MM, Mota RA, de Souza EM, Stephens CE, Som P, Boykin DW, Soeiro Mde N.

Biochem Pharmacol. 2007 Jun 15;73(12):1939-46. Epub 2007 Mar 24.

PMID:
17462605
16.

2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

Salmon-Chemin L, Buisine E, Yardley V, Kohler S, Debreu MA, Landry V, Sergheraert C, Croft SL, Krauth-Siegel RL, Davioud-Charvet E.

J Med Chem. 2001 Feb 15;44(4):548-65.

PMID:
11170645
17.

On the search for potential anti-Trypanosoma cruzi drugs: synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions.

da Silva Júnior EN, de Melo IM, Diogo EB, Costa VA, de Souza Filho JD, Valença WO, Camara CA, de Oliveira RN, de Araujo AS, Emery FS, dos Santos MR, de Simone CA, Menna-Barreto RF, de Castro SL.

Eur J Med Chem. 2012 Jun;52:304-12. doi: 10.1016/j.ejmech.2012.03.039. Epub 2012 Mar 29.

PMID:
22483633
18.

The effects on Trypanosoma cruzi of novel synthetic naphthoquinones are mediated by mitochondrial dysfunction.

Menna-Barreto RF, Goncalves RL, Costa EM, Silva RS, Pinto AV, Oliveira MF, de Castro SL.

Free Radic Biol Med. 2009 Sep 1;47(5):644-53. doi: 10.1016/j.freeradbiomed.2009.06.004. Epub 2009 Jun 6.

PMID:
19501647
19.

Trypanocidal activity of 5,6-dihydropyran-2-ones against free trypomastigotes forms of Trypanosoma cruzi.

de Fátima A, Marquissolo C, de Albuquerque S, Carraro-Abrahão AA, Pilli RA.

Eur J Med Chem. 2006 Oct;41(10):1210-3. Epub 2006 Jul 3.

PMID:
16815596
20.

Synthesis, biological evaluation and chemometric analysis of indazole derivatives. 1,2-Disubstituted 5-nitroindazolinones, new prototypes of antichagasic drug.

Vega MC, Rolón M, Montero-Torres A, Fonseca-Berzal C, Escario JA, Gómez-Barrio A, Gálvez J, Marrero-Ponce Y, Arán VJ.

Eur J Med Chem. 2012 Dec;58:214-27. doi: 10.1016/j.ejmech.2012.10.009. Epub 2012 Oct 16.

PMID:
23124218

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