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Identification and functional studies of a new Nrf2 partner IQGAP1: a critical role in the stability and transactivation of Nrf2.

Kim JH, Xu EY, Sacks DB, Lee J, Shu L, Xia B, Kong AN.

Antioxid Redox Signal. 2013 Jul 10;19(2):89-101. doi: 10.1089/ars.2012.4586. Epub 2012 Sep 17.


The Ras GTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK pathway.

Cheung KL, Lee JH, Shu L, Kim JH, Sacks DB, Kong AN.

J Biol Chem. 2013 Aug 2;288(31):22378-86. doi: 10.1074/jbc.M112.444182. Epub 2013 Jun 20.


The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains.

Kim JH, Yu S, Chen JD, Kong AN.

Oncogene. 2013 Jan 24;32(4):514-27. doi: 10.1038/onc.2012.59. Epub 2012 Feb 27.


PM2.5 induces Nrf2-mediated defense mechanisms against oxidative stress by activating PIK3/AKT signaling pathway in human lung alveolar epithelial A549 cells.

Deng X, Rui W, Zhang F, Ding W.

Cell Biol Toxicol. 2013 Jun;29(3):143-57. doi: 10.1007/s10565-013-9242-5. Epub 2013 Mar 24.


Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defenses.

Biswas C, Shah N, Muthu M, La P, Fernando AP, Sengupta S, Yang G, Dennery PA.

J Biol Chem. 2014 Sep 26;289(39):26882-94. doi: 10.1074/jbc.M114.567685. Epub 2014 Aug 8.


Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target.

Almazari I, Park JM, Park SA, Suh JY, Na HK, Cha YN, Surh YJ.

Carcinogenesis. 2012 Feb;33(2):368-76. doi: 10.1093/carcin/bgr259. Epub 2011 Nov 17.


Piper betle induces phase I & II genes through Nrf2/ARE signaling pathway in mouse embryonic fibroblasts derived from wild type and Nrf2 knockout cells.

Wan Hasan WN, Kwak MK, Makpol S, Wan Ngah WZ, Mohd Yusof YA.

BMC Complement Altern Med. 2014 Feb 23;14:72. doi: 10.1186/1472-6882-14-72.


Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling.

Lee HH, Park SA, Almazari I, Kim EH, Na HK, Surh YJ.

Arch Biochem Biophys. 2010 Sep 1;501(1):142-50. doi: 10.1016/ Epub 2010 Jun 15.


Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene.

Ray PD, Huang BW, Tsuji Y.

Biochim Biophys Acta. 2015 Oct;1849(10):1277-88. doi: 10.1016/j.bbagrm.2015.08.004. Epub 2015 Aug 18.


Effect of 7, 8-dihydroxyflavone on the up-regulation of Nrf2-mediated heme oxygenase-1 expression in hamster lung fibroblasts.

Ryu MJ, Kang KA, Piao MJ, Kim KC, Zheng J, Yao CW, Cha JW, Hyun CL, Chung HS, Park JC, Cho SJ, Hyun JW.

In Vitro Cell Dev Biol Anim. 2014 Jun;50(6):549-54. doi: 10.1007/s11626-014-9735-4. Epub 2014 Mar 8.


tBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and polymerase II to promoter region of HO-1.

Cheung KL, Yu S, Pan Z, Ma J, Wu TY, Kong AN.

Chem Res Toxicol. 2011 May 16;24(5):670-6. doi: 10.1021/tx1004369. Epub 2011 Apr 5.


Activation of Nrf2 in defense against cadmium-induced oxidative stress.

He X, Chen MG, Ma Q.

Chem Res Toxicol. 2008 Jul;21(7):1375-83. doi: 10.1021/tx800019a. Epub 2008 May 31.


Nuclear factor erythroid 2-related factor 2 nuclear translocation induces myofibroblastic dedifferentiation in idiopathic pulmonary fibrosis.

Artaud-Macari E, Goven D, Brayer S, Hamimi A, Besnard V, Marchal-Somme J, Ali ZE, Crestani B, Kerdine-Römer S, Boutten A, Bonay M.

Antioxid Redox Signal. 2013 Jan 1;18(1):66-79. doi: 10.1089/ars.2011.4240. Epub 2012 Aug 6.


Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes.

Zhang J, Hosoya T, Maruyama A, Nishikawa K, Maher JM, Ohta T, Motohashi H, Fukamizu A, Shibahara S, Itoh K, Yamamoto M.

Biochem J. 2007 Jun 15;404(3):459-66.


Activation of nuclear factor erythroid 2-related factor 2 and PPARγ plays a role in the genistein-mediated attenuation of oxidative stress-induced endothelial cell injury.

Zhang T, Wang F, Xu HX, Yi L, Qin Y, Chang H, Mi MT, Zhang QY.

Br J Nutr. 2013 Jan 28;109(2):223-35. doi: 10.1017/S0007114512001110. Epub 2012 May 3.


Activation of Nrf2 contributes to the protective effect of Exendin-4 against angiotensin II-induced vascular smooth muscle cell senescence.

Zhou T, Zhang M, Zhao L, Li A, Qin X.

Am J Physiol Cell Physiol. 2016 Oct 1;311(4):C572-C582. doi: 10.1152/ajpcell.00093.2016. Epub 2016 Aug 3.


Nrf2-dependent and Nrf2-independent induction of phase 2 detoxifying and antioxidant enzymes during keratinocyte differentiation.

Piao MS, Park JJ, Choi JY, Lee DH, Yun SJ, Lee JB, Lee SC.

Arch Dermatol Res. 2012 Jul;304(5):387-95. doi: 10.1007/s00403-012-1215-7. Epub 2012 Feb 5.


Oroxylin A exerts anti-inflammatory activity on lipopolysaccharide-induced mouse macrophage via Nrf2/ARE activation.

Ye M, Wang Q, Zhang W, Li Z, Wang Y, Hu R.

Biochem Cell Biol. 2014 Oct;92(5):337-48. doi: 10.1139/bcb-2014-0030. Epub 2014 Jul 17.


Identification of activating transcription factor 4 (ATF4) as an Nrf2-interacting protein. Implication for heme oxygenase-1 gene regulation.

He CH, Gong P, Hu B, Stewart D, Choi ME, Choi AM, Alam J.

J Biol Chem. 2001 Jun 15;276(24):20858-65. Epub 2001 Mar 26.


PECAM-1-dependent heme oxygenase-1 regulation via an Nrf2-mediated pathway in endothelial cells.

Saragih H, Zilian E, Jaimes Y, Paine A, Figueiredo C, Eiz-Vesper B, Blasczyk R, Larmann J, Theilmeier G, Burg-Roderfeld M, Andrei-Selmer LC, Becker JU, Santoso S, Immenschuh S.

Thromb Haemost. 2014 Jun;111(6):1077-88. doi: 10.1160/TH13-11-0923. Epub 2014 Feb 6.


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