Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 127


Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity.

Wang H, Megill A, He K, Kirkwood A, Lee HK.

Neural Plast. 2012;2012:272374. doi: 10.1155/2012/272374. Epub 2012 Jun 26. Review.


Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease.

Caccamo A, Branca C, Talboom JS, Shaw DM, Turner D, Ma L, Messina A, Huang Z, Wu J, Oddo S.

J Neurosci. 2015 Oct 14;35(41):14042-56. doi: 10.1523/JNEUROSCI.2781-15.2015.


Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.

Ma H, Lesné S, Kotilinek L, Steidl-Nichols JV, Sherman M, Younkin L, Younkin S, Forster C, Sergeant N, Delacourte A, Vassar R, Citron M, Kofuji P, Boland LM, Ashe KH.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):8167-72. Epub 2007 Apr 30.


Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.

Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.

Eur J Neurosci. 2013 Jun;37(12):1962-9. doi: 10.1111/ejn.12235.


Alzheimer's disease.

De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV.

Subcell Biochem. 2012;65:329-52. doi: 10.1007/978-94-007-5416-4_14. Review.


The molecular link between beta- and gamma-secretase activity on the amyloid beta precursor protein.

Tabaton M, Tamagno E.

Cell Mol Life Sci. 2007 Sep;64(17):2211-8. Review.


Synaptic dysfunction in Alzheimer's disease.

Marcello E, Epis R, Saraceno C, Di Luca M.

Adv Exp Med Biol. 2012;970:573-601. doi: 10.1007/978-3-7091-0932-8_25. Review.


Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.

McConlogue L, Buttini M, Anderson JP, Brigham EF, Chen KS, Freedman SB, Games D, Johnson-Wood K, Lee M, Zeller M, Liu W, Motter R, Sinha S.

J Biol Chem. 2007 Sep 7;282(36):26326-34. Epub 2007 Jul 6.


Partial reduction of BACE1 improves synaptic plasticity, recent and remote memories in Alzheimer's disease transgenic mice.

Kimura R, Devi L, Ohno M.

J Neurochem. 2010 Apr;113(1):248-61. doi: 10.1111/j.1471-4159.2010.06608.x. Epub 2010 Jan 20.


Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses.

Almeida CG, Tampellini D, Takahashi RH, Greengard P, Lin MT, Snyder EM, Gouras GK.

Neurobiol Dis. 2005 Nov;20(2):187-98.


Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity.

Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ.

Biochemistry. 2014 Jun 24;53(24):3908-21.


Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development.

Zhang XM, Cai Y, Xiong K, Cai H, Luo XG, Feng JC, Clough RW, Struble RG, Patrylo PR, Yan XX.

Eur J Neurosci. 2009 Dec;30(12):2271-83. doi: 10.1111/j.1460-9568.2009.07017.x. Epub 2009 Dec 10.


Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation.

Obregon D, Hou H, Deng J, Giunta B, Tian J, Darlington D, Shahaduzzaman M, Zhu Y, Mori T, Mattson MP, Tan J.

Nat Commun. 2012 Apr 10;3:777. doi: 10.1038/ncomms1781.


Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations.

Tampellini D, Rahman N, Gallo EF, Huang Z, Dumont M, Capetillo-Zarate E, Ma T, Zheng R, Lu B, Nanus DM, Lin MT, Gouras GK.

J Neurosci. 2009 Aug 5;29(31):9704-13. doi: 10.1523/JNEUROSCI.2292-09.2009.


Impairments of long-term depression induction and motor coordination precede Aβ accumulation in the cerebellum of APPswe/PS1dE9 double transgenic mice.

Kuwabara Y, Ishizeki M, Watamura N, Toba J, Yoshii A, Inoue T, Ohshima T.

J Neurochem. 2014 Aug;130(3):432-43. doi: 10.1111/jnc.12728. Epub 2014 Apr 19.


Role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation.

Hou P, Liu G, Zhao Y, Shi Z, Zheng Q, Bu G, Xu H, Zhang YW.

Neurobiol Aging. 2015 Mar;36(3):1310-5. doi: 10.1016/j.neurobiolaging.2014.12.005. Epub 2014 Dec 11.


Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo.

Kim ML, Zhang B, Mills IP, Milla ME, Brunden KR, Lee VM.

J Neurosci. 2008 Nov 12;28(46):12052-61. doi: 10.1523/JNEUROSCI.2913-08.2008.


Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.

Liang B, Duan BY, Zhou XP, Gong JX, Luo ZG.

J Biol Chem. 2010 Sep 3;285(36):27737-44. doi: 10.1074/jbc.M110.117960. Epub 2010 Jul 1.


BACE1 as a therapeutic target in Alzheimer's disease: rationale and current status.

Evin G, Hince C.

Drugs Aging. 2013 Oct;30(10):755-64. doi: 10.1007/s40266-013-0099-3. Review.

Items per page

Supplemental Content

Support Center