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Items: 1 to 20 of 119

1.

Characterisation of the first enzymes committed to lysine biosynthesis in Arabidopsis thaliana.

Griffin MD, Billakanti JM, Wason A, Keller S, Mertens HD, Atkinson SC, Dobson RC, Perugini MA, Gerrard JA, Pearce FG.

PLoS One. 2012;7(7):e40318. doi: 10.1371/journal.pone.0040318. Epub 2012 Jul 5.

2.

The structure of dihydrodipicolinate reductase (DapB) from Mycobacterium tuberculosis in three crystal forms.

Janowski R, Kefala G, Weiss MS.

Acta Crystallogr D Biol Crystallogr. 2010 Jan;66(Pt 1):61-72. doi: 10.1107/S0907444909043960. Epub 2009 Dec 21.

PMID:
20057050
3.

Crystallization and preliminary X-ray diffraction analysis of dihydrodipicolinate synthase 2 from Arabidopsis thaliana.

Griffin MD, Billakanti JM, Gerrard JA, Dobson RC, Pearce FG.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1386-90. doi: 10.1107/S1744309111033276. Epub 2011 Oct 27.

4.

Structural, kinetic and computational investigation of Vitis vinifera DHDPS reveals new insight into the mechanism of lysine-mediated allosteric inhibition.

Atkinson SC, Dogovski C, Downton MT, Czabotar PE, Dobson RC, Gerrard JA, Wagner J, Perugini MA.

Plant Mol Biol. 2013 Mar;81(4-5):431-46. doi: 10.1007/s11103-013-0014-7. Epub 2013 Jan 26.

PMID:
23354837
5.

Structure and evolution of a novel dimeric enzyme from a clinically important bacterial pathogen.

Burgess BR, Dobson RC, Bailey MF, Atkinson SC, Griffin MD, Jameson GB, Parker MW, Gerrard JA, Perugini MA.

J Biol Chem. 2008 Oct 10;283(41):27598-603. doi: 10.1074/jbc.M804231200. Epub 2008 Aug 5.

6.

Crystal, solution and in silico structural studies of dihydrodipicolinate synthase from the common grapevine.

Atkinson SC, Dogovski C, Downton MT, Pearce FG, Reboul CF, Buckle AM, Gerrard JA, Dobson RC, Wagner J, Perugini MA.

PLoS One. 2012;7(6):e38318. doi: 10.1371/journal.pone.0038318. Epub 2012 Jun 25.

7.

Structure and Function of Cyanobacterial DHDPS and DHDPR.

Christensen JB, Soares da Costa TP, Faou P, Pearce FG, Panjikar S, Perugini MA.

Sci Rep. 2016 Nov 15;6:37111. doi: 10.1038/srep37111.

8.

Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis.

Kefala G, Evans GL, Griffin MD, Devenish SR, Pearce FG, Perugini MA, Gerrard JA, Weiss MS, Dobson RC.

Biochem J. 2008 Apr 15;411(2):351-60.

PMID:
18062777
9.

The crystal structures of native and (S)-lysine-bound dihydrodipicolinate synthase from Escherichia coli with improved resolution show new features of biological significance.

Dobson RC, Griffin MD, Jameson GB, Gerrard JA.

Acta Crystallogr D Biol Crystallogr. 2005 Aug;61(Pt 8):1116-24. Epub 2005 Jul 20.

PMID:
16041077
10.

Structural and functional characterization of Staphylococcus aureus dihydrodipicolinate synthase.

Girish TS, Sharma E, Gopal B.

FEBS Lett. 2008 Aug 20;582(19):2923-30. doi: 10.1016/j.febslet.2008.07.035. Epub 2008 Jul 29.

11.

Characterization of dihydrodipicolinate reductase from Thermotoga maritima reveals evolution of substrate binding kinetics.

Pearce FG, Sprissler C, Gerrard JA.

J Biochem. 2008 May;143(5):617-23. doi: 10.1093/jb/mvn012. Epub 2008 Feb 4.

PMID:
18250105
12.

Crystal structure of LL-diaminopimelate aminotransferase from Arabidopsis thaliana: a recently discovered enzyme in the biosynthesis of L-lysine by plants and Chlamydia.

Watanabe N, Cherney MM, van Belkum MJ, Marcus SL, Flegel MD, Clay MD, Deyholos MK, Vederas JC, James MN.

J Mol Biol. 2007 Aug 17;371(3):685-702. Epub 2007 May 26.

PMID:
17583737
13.

Regulatory mechanisms after short- and long-term perturbed lysine biosynthesis in the aspartate pathway: the need for isogenes in Arabidopsis thaliana.

Van Bochaute P, Novoa A, Ballet S, Rognes SE, Angenon G.

Physiol Plant. 2013 Dec;149(4):449-60. doi: 10.1111/ppl.12053. Epub 2013 Apr 15.

PMID:
23556418
14.

Structure of dihydrodipicolinate synthase from Methanocaldococcus jannaschii.

Padmanabhan B, Strange RW, Antonyuk SV, Ellis MJ, Hasnain SS, Iino H, Agari Y, Bessho Y, Yokoyama S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Dec 1;65(Pt 12):1222-6. doi: 10.1107/S174430910904651X. Epub 2009 Nov 27.

15.

Mutating the tight-dimer interface of dihydrodipicolinate synthase disrupts the enzyme quaternary structure: toward a monomeric enzyme.

Pearce FG, Dobson RC, Weber A, Lane LA, McCammon MG, Squire MA, Perugini MA, Jameson GB, Robinson CV, Gerrard JA.

Biochemistry. 2008 Nov 18;47(46):12108-17. doi: 10.1021/bi801094t. Epub 2008 Oct 21.

PMID:
18937497
16.

A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis.

Evans G, Schuldt L, Griffin MD, Devenish SR, Grant Pearce F, Perugini MA, Dobson RC, Jameson GB, Weiss MS, Gerrard JA.

Arch Biochem Biophys. 2011 Aug 15;512(2):154-9. doi: 10.1016/j.abb.2011.05.014. Epub 2011 Jun 7.

PMID:
21672512
17.

NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase.

Devenish SR, Blunt JW, Gerrard JA.

J Med Chem. 2010 Jun 24;53(12):4808-12. doi: 10.1021/jm100349s.

PMID:
20503968
18.

Dihydrodipicolinate synthase from Thermotoga maritima.

Pearce FG, Perugini MA, McKerchar HJ, Gerrard JA.

Biochem J. 2006 Dec 1;400(2):359-66.

19.

Structural and dynamic requirements for optimal activity of the essential bacterial enzyme dihydrodipicolinate synthase.

Reboul CF, Porebski BT, Griffin MD, Dobson RC, Perugini MA, Gerrard JA, Buckle AM.

PLoS Comput Biol. 2012;8(6):e1002537. doi: 10.1371/journal.pcbi.1002537. Epub 2012 Jun 7.

20.

Crystal structure of dihydrodipicolinate synthase from Hahella chejuensis at 1.5 A resolution.

Kang BS, Kim YG, Ahn JW, Kim KJ.

Int J Biol Macromol. 2010 Jun;46(5):512-6. doi: 10.1016/j.ijbiomac.2010.03.005. Epub 2010 Mar 20.

PMID:
20227435

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