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Items: 1 to 20 of 109

1.

Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells.

Camilo V, Barros R, Sousa S, Magalhães AM, Lopes T, Mário Santos A, Pereira T, Figueiredo C, David L, Almeida R.

Carcinogenesis. 2012 Oct;33(10):1985-92. doi: 10.1093/carcin/bgs233. Epub 2012 Jul 12.

PMID:
22791809
2.

Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines.

Barros R, Pereira B, Duluc I, Azevedo M, Mendes N, Camilo V, Jacobs RJ, Paulo P, Santos-Silva F, van Seuningen I, van den Brink GR, David L, Freund JN, Almeida R.

J Pathol. 2008 Aug;215(4):411-20. doi: 10.1002/path.2369.

PMID:
18498120
3.

Helicobacter pylori induces gastric mucosal intestinal metaplasia through the inhibition of interleukin-4-mediated HMG box protein Sox2 expression.

Asonuma S, Imatani A, Asano N, Oikawa T, Konishi H, Iijima K, Koike T, Ohara S, Shimosegawa T.

Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G312-22. doi: 10.1152/ajpgi.00518.2007. Epub 2009 Jun 11.

4.

Inactivation of NKX6.3 in the stomach leads to abnormal expression of CDX2 and SOX2 required for gastric-to-intestinal transdifferentiation.

Yoon JH, Choi SS, Kim O, Choi WS, Park YK, Nam SW, Lee JY, Park WS.

Mod Pathol. 2016 Feb;29(2):194-208. doi: 10.1038/modpathol.2015.150. Epub 2016 Jan 8.

5.

Sox2 expression is maintained while gastric phenotype is completely lost in Cdx2-induced intestinal metaplastic mucosa.

Mutoh H, Sashikawa M, Sugano K.

Differentiation. 2011 Feb;81(2):92-8. doi: 10.1016/j.diff.2010.10.002. Epub 2010 Oct 30.

PMID:
21036460
6.
7.

Dysregulation of CDX1, CDX2 and SOX2 in patients with gastric cancer also affects the non-malignant mucosa.

Bornschein J, Tóth K, Selgrad M, Kuester D, Wex T, Molnár B, Tulassay Z, Malfertheiner P.

J Clin Pathol. 2013 Sep;66(9):819-22. doi: 10.1136/jclinpath-2013-201448. Epub 2013 Apr 23.

PMID:
23613102
8.

Intestine-specific homeobox (ISX) induces intestinal metaplasia and cell proliferation to contribute to gastric carcinogenesis.

Sue S, Shibata W, Kameta E, Sato T, Ishii Y, Kaneko H, Miwa H, Sasaki T, Tamura T, Kondo M, Maeda S.

J Gastroenterol. 2016 Oct;51(10):949-60. doi: 10.1007/s00535-016-1176-2. Epub 2016 Feb 12.

PMID:
26872890
9.

Differentiation reprogramming in gastric intestinal metaplasia and dysplasia: role of SOX2 and CDX2.

Camilo V, Garrido M, Valente P, Ricardo S, Amaral AL, Barros R, Chaves P, Carneiro F, David L, Almeida R.

Histopathology. 2015 Feb;66(3):343-50. doi: 10.1111/his.12544. Epub 2014 Nov 10.

PMID:
25196071
10.

CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype.

Barros R, da Costa LT, Pinto-de-Sousa J, Duluc I, Freund JN, David L, Almeida R.

Gut. 2011 Mar;60(3):290-8. doi: 10.1136/gut.2010.222323. Epub 2010 Dec 9.

11.

Aberrant expression of CDX2 in the gastric mucosa with and without intestinal metaplasia: effect of eradication of Helicobacter pylori.

Satoh K, Mutoh H, Eda A, Yanaka I, Osawa H, Honda S, Kawata H, Kihira K, Sugano K.

Helicobacter. 2002 Jun;7(3):192-8.

PMID:
12047325
12.

Expression of intestine-specific transcription factors, CDX1 and CDX2, in intestinal metaplasia and gastric carcinomas.

Almeida R, Silva E, Santos-Silva F, Silberg DG, Wang J, De Bolós C, David L.

J Pathol. 2003 Jan;199(1):36-40.

PMID:
12474224
13.

OCT-1 is over-expressed in intestinal metaplasia and intestinal gastric carcinomas and binds to, but does not transactivate, CDX2 in gastric cells.

Almeida R, Almeida J, Shoshkes M, Mendes N, Mesquita P, Silva E, Van Seuningen I, Reis CA, Santos-Silva F, David L.

J Pathol. 2005 Dec;207(4):396-401.

PMID:
16278805
14.

Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses.

Asano N, Imatani A, Watanabe T, Fushiya J, Kondo Y, Jin X, Ara N, Uno K, Iijima K, Koike T, Strober W, Shimosegawa T.

Cancer Res. 2016 Mar 1;76(5):1135-45. doi: 10.1158/0008-5472.CAN-15-2272. Epub 2016 Jan 12.

15.

Determinants of gastric CDX2 expression: a study in Mozambique.

Peleteiro B, Barros R, Carrilho C, Artiaga J, Cunha L, Modcoicar P, Ferreira R, Figueiredo C, Almeida R, La Vecchia C, David L, Barros H, Lunet N.

Eur J Cancer Prev. 2012 Nov;21(6):532-40.

PMID:
22407102
16.

Monocyte chemoattractant protein-1 is generated via TGF-beta by myofibroblasts in gastric intestinal metaplasia and carcinoma without H. pylori infection.

Mutoh H, Sashikawa M, Hayakawa H, Sugano K.

Cancer Sci. 2010 Aug;101(8):1783-9. doi: 10.1111/j.1349-7006.2010.01609.x. Epub 2010 Apr 29.

17.

SOX2 Inhibition Promotes Promoter Demethylation of CDX2 to Facilitate Gastric Intestinal Metaplasia.

Niu H, Jia Y, Li T, Su B.

Dig Dis Sci. 2017 Jan;62(1):124-132. doi: 10.1007/s10620-016-4361-5. Epub 2016 Dec 2.

PMID:
27913994
18.

Down-regulation of a gastric transcription factor, Sox2, and ectopic expression of intestinal homeobox genes, Cdx1 and Cdx2: inverse correlation during progression from gastric/intestinal-mixed to complete intestinal metaplasia.

Tsukamoto T, Inada K, Tanaka H, Mizoshita T, Mihara M, Ushijima T, Yamamura Y, Nakamura S, Tatematsu M.

J Cancer Res Clin Oncol. 2004 Mar;130(3):135-45. Epub 2003 Dec 4.

PMID:
14655050
19.

Celecoxib inhibits Cdx2 expression and prevents gastric cancer in Helicobacter pylori-infected Mongolian gerbils.

Futagami S, Suzuki K, Hiratsuka T, Shindo T, Hamamoto T, Tatsuguchi A, Ueki N, Shinji Y, Kusunoki M, Wada K, Miyake K, Gudis K, Tsukui T, Sakamoto C.

Digestion. 2006;74(3-4):187-98. Epub 2007 Mar 6.

PMID:
17341852
20.

Alterations of gastric homeoprotein expression in Helicobacter pylori infection, incisural antralisation, and intestinal metaplasia.

Zhu S, Xia HH, Yang Y, Ma J, Chen M, Hu P, Gu Q, Liang Y, Lin H, Wong BC.

Dig Dis Sci. 2009 May;54(5):996-1002. doi: 10.1007/s10620-008-0459-8. Epub 2008 Aug 27.

PMID:
18754095

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