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Items: 1 to 20 of 84

1.

Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53.

Bywater MJ, Poortinga G, Sanij E, Hein N, Peck A, Cullinane C, Wall M, Cluse L, Drygin D, Anderes K, Huser N, Proffitt C, Bliesath J, Haddach M, Schwaebe MK, Ryckman DM, Rice WG, Schmitt C, Lowe SW, Johnstone RW, Pearson RB, McArthur GA, Hannan RD.

Cancer Cell. 2012 Jul 10;22(1):51-65. doi: 10.1016/j.ccr.2012.05.019.

2.

Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.

Drygin D, Lin A, Bliesath J, Ho CB, O'Brien SE, Proffitt C, Omori M, Haddach M, Schwaebe MK, Siddiqui-Jain A, Streiner N, Quin JE, Sanij E, Bywater MJ, Hannan RD, Ryckman D, Anderes K, Rice WG.

Cancer Res. 2011 Feb 15;71(4):1418-30. doi: 10.1158/0008-5472.CAN-10-1728. Epub 2010 Dec 15.

3.

The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy.

Woods SJ, Hannan KM, Pearson RB, Hannan RD.

Biochim Biophys Acta. 2015 Jul;1849(7):821-9. doi: 10.1016/j.bbagrm.2014.10.007. Epub 2014 Nov 11. Review.

PMID:
25464032
4.

Targeting the nucleolus for cancer intervention.

Quin JE, Devlin JR, Cameron D, Hannan KM, Pearson RB, Hannan RD.

Biochim Biophys Acta. 2014 Jun;1842(6):802-16. doi: 10.1016/j.bbadis.2013.12.009. Epub 2014 Jan 2. Review.

6.

Targeting the nucleolus for cancer-specific activation of p53.

Drygin D, O'Brien SE, Hannan RD, McArthur GA, Von Hoff DD.

Drug Discov Today. 2014 Mar;19(3):259-65. doi: 10.1016/j.drudis.2013.08.012. Epub 2013 Aug 28. Review.

PMID:
23993916
7.

p53 represses ribosomal gene transcription.

Budde A, Grummt I.

Oncogene. 1999 Jan 28;18(4):1119-24.

8.

Combination Therapy Targeting Ribosome Biogenesis and mRNA Translation Synergistically Extends Survival in MYC-Driven Lymphoma.

Devlin JR, Hannan KM, Hein N, Cullinane C, Kusnadi E, Ng PY, George AJ, Shortt J, Bywater MJ, Poortinga G, Sanij E, Kang J, Drygin D, O'Brien S, Johnstone RW, McArthur GA, Hannan RD, Pearson RB.

Cancer Discov. 2016 Jan;6(1):59-70. doi: 10.1158/2159-8290.CD-14-0673. Epub 2015 Oct 21.

9.

Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity.

Quotti Tubi L, Gurrieri C, Brancalion A, Bonaldi L, Bertorelle R, Manni S, Pavan L, Lessi F, Zambello R, Trentin L, Adami F, Ruzzene M, Pinna LA, Semenzato G, Piazza F.

J Hematol Oncol. 2013 Oct 12;6:78. doi: 10.1186/1756-8722-6-78.

10.

Non-genotoxic activation of p53 through the RPL11-dependent ribosomal stress pathway.

Morgado-Palacin L, Llanos S, Urbano-Cuadrado M, Blanco-Aparicio C, Megias D, Pastor J, Serrano M.

Carcinogenesis. 2014 Dec;35(12):2822-30. doi: 10.1093/carcin/bgu220. Epub 2014 Oct 24.

PMID:
25344835
11.

BLM helicase facilitates RNA polymerase I-mediated ribosomal RNA transcription.

Grierson PM, Lillard K, Behbehani GK, Combs KA, Bhattacharyya S, Acharya S, Groden J.

Hum Mol Genet. 2012 Mar 1;21(5):1172-83. doi: 10.1093/hmg/ddr545. Epub 2011 Nov 21.

12.

1A6/DRIM, a novel t-UTP, activates RNA polymerase I transcription and promotes cell proliferation.

Peng Q, Wu J, Zhang Y, Liu Y, Kong R, Hu L, Du X, Ke Y.

PLoS One. 2010 Dec 7;5(12):e14244. doi: 10.1371/journal.pone.0014244.

13.

Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation.

Donati G, Brighenti E, Vici M, Mazzini G, Treré D, Montanaro L, Derenzini M.

J Cell Sci. 2011 Sep 1;124(Pt 17):3017-28. doi: 10.1242/jcs.086074.

14.
15.

Mouse and frog violate the paradigm of species-specific transcription of ribosomal RNA genes.

Culotta VC, Wilkinson JK, Sollner-Webb B.

Proc Natl Acad Sci U S A. 1987 Nov;84(21):7498-502.

16.

Glucocorticoid inhibition of initiation of transcription of the DNA encoding rRNA (rDNA) in lymphosarcoma P1798 cells.

Cavanaugh AH, Gokal PK, Lawther RP, Thompson EA Jr.

Proc Natl Acad Sci U S A. 1984 Feb;81(3):718-21.

17.

The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks.

Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R.

Nature. 2007 Jun 7;447(7145):730-4.

PMID:
17554310
18.

Mutation of a Nopp140 gene dao-5 alters rDNA transcription and increases germ cell apoptosis in C. elegans.

Lee CC, Tsai YT, Kao CW, Lee LW, Lai HJ, Ma TH, Chang YS, Yeh NH, Lo SJ.

Cell Death Dis. 2014 Apr 10;5:e1158. doi: 10.1038/cddis.2014.114.

PMID:
24722283
19.

The nucleolus: an emerging target for cancer therapy.

Hein N, Hannan KM, George AJ, Sanij E, Hannan RD.

Trends Mol Med. 2013 Nov;19(11):643-54. doi: 10.1016/j.molmed.2013.07.005. Epub 2013 Aug 15. Review.

PMID:
23953479
20.

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling.

Quin J, Chan KT, Devlin JR, Cameron DP, Diesch J, Cullinane C, Ahern J, Khot A, Hein N, George AJ, Hannan KM, Poortinga G, Sheppard KE, Khanna KK, Johnstone RW, Drygin D, McArthur GA, Pearson RB, Sanij E, Hannan RD.

Oncotarget. 2016 Aug 2;7(31):49800-49818. doi: 10.18632/oncotarget.10452.

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