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Items: 1 to 20 of 157

1.

Bacillus anthracis inosine 5'-monophosphate dehydrogenase in action: the first bacterial series of structures of phosphate ion-, substrate-, and product-bound complexes.

Makowska-Grzyska M, Kim Y, Wu R, Wilton R, Gollapalli DR, Wang XK, Zhang R, Jedrzejczak R, Mack JC, Maltseva N, Mulligan R, Binkowski TA, Gornicki P, Kuhn ML, Anderson WF, Hedstrom L, Joachimiak A.

Biochemistry. 2012 Aug 7;51(31):6148-63. Epub 2012 Jul 25.

2.

A novel cofactor-binding mode in bacterial IMP dehydrogenases explains inhibitor selectivity.

Makowska-Grzyska M, Kim Y, Maltseva N, Osipiuk J, Gu M, Zhang M, Mandapati K, Gollapalli DR, Gorla SK, Hedstrom L, Joachimiak A.

J Biol Chem. 2015 Feb 27;290(9):5893-911. doi: 10.1074/jbc.M114.619767. Epub 2015 Jan 8.

3.

Crystal structure at 2.4 A resolution of Borrelia burgdorferi inosine 5'-monophosphate dehydrogenase: evidence of a substrate-induced hinged-lid motion by loop 6.

McMillan FM, Cahoon M, White A, Hedstrom L, Petsko GA, Ringe D.

Biochemistry. 2000 Apr 18;39(15):4533-42.

PMID:
10758003
4.

Species-specific inhibition of inosine 5'-monophosphate dehydrogenase by mycophenolic acid.

Digits JA, Hedstrom L.

Biochemistry. 1999 Nov 16;38(46):15388-97.

PMID:
10563825
7.

IMP dehydrogenase: the dynamics of drug selectivity.

Hedstrom L, Gan L, Schlippe YG, Riera T, Seyedsayamdost M.

Nucleic Acids Res Suppl. 2003;(3):97-8.

PMID:
14510398
8.

The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitors.

Sintchak MD, Nimmesgern E.

Immunopharmacology. 2000 May;47(2-3):163-84. Review.

PMID:
10878288
10.

Structure and mechanism of inosine monophosphate dehydrogenase in complex with the immunosuppressant mycophenolic acid.

Sintchak MD, Fleming MA, Futer O, Raybuck SA, Chambers SP, Caron PR, Murcko MA, Wilson KP.

Cell. 1996 Jun 14;85(6):921-30.

12.

Inactivation of inosine 5'-monophosphate dehydrogenase by the antiviral agent 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide 5'-monophosphate.

Wang W, Papov VV, Minakawa N, Matsuda A, Biemann K, Hedstrom L.

Biochemistry. 1996 Jan 9;35(1):95-101.

PMID:
8555204
13.

A kinetic alignment of orthologous inosine-5'-monophosphate dehydrogenases.

Riera TV, Wang W, Josephine HR, Hedstrom L.

Biochemistry. 2008 Aug 19;47(33):8689-96. doi: 10.1021/bi800674a. Epub 2008 Jul 22.

14.

Inhibition of IMPDH by mycophenolic acid: dissection of forward and reverse pathways using capillary electrophoresis.

Fleming MA, Chambers SP, Connelly PR, Nimmesgern E, Fox T, Bruzzese FJ, Hoe ST, Fulghum JR, Livingston DJ, Stuver CM, Sintchak MD, Wilson KP, Thomson JA.

Biochemistry. 1996 Jun 4;35(22):6990-7.

PMID:
8679523
15.

Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds.

Makowska-Grzyska M, Kim Y, Gorla SK, Wei Y, Mandapati K, Zhang M, Maltseva N, Modi G, Boshoff HI, Gu M, Aldrich C, Cuny GD, Hedstrom L, Joachimiak A.

PLoS One. 2015 Oct 6;10(10):e0138976. doi: 10.1371/journal.pone.0138976. eCollection 2015.

16.

Characteristics and crystal structure of bacterial inosine-5'-monophosphate dehydrogenase.

Zhang R, Evans G, Rotella FJ, Westbrook EM, Beno D, Huberman E, Joachimiak A, Collart FR.

Biochemistry. 1999 Apr 13;38(15):4691-700.

PMID:
10200156
17.

Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.

Nair V, Shu Q.

Antivir Chem Chemother. 2007;18(5):245-58. Review.

PMID:
18046958
18.

Inhibition of Inosine-5'-monophosphate Dehydrogenase from Bacillus anthracis: Mechanism Revealed by Pre-Steady-State Kinetics.

Wei Y, Kuzmi─Ź P, Yu R, Modi G, Hedstrom L.

Biochemistry. 2016 Sep 20;55(37):5279-88. doi: 10.1021/acs.biochem.6b00265. Epub 2016 Sep 2.

19.

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