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Items: 1 to 20 of 122


In vivo emergence of Aspergillus terreus with reduced azole susceptibility and a Cyp51a M217I alteration.

Arendrup MC, Jensen RH, Grif K, Skov M, Pressler T, Johansen HK, Lass-Flörl C.

J Infect Dis. 2012 Sep 15;206(6):981-5. doi: 10.1093/infdis/jis442. Epub 2012 Jul 10.


In Vitro Activity of ASP2397 against Aspergillus Isolates with or without Acquired Azole Resistance Mechanisms.

Arendrup MC, Jensen RH, Cuenca-Estrella M.

Antimicrob Agents Chemother. 2015 Nov 9;60(1):532-6. doi: 10.1128/AAC.02336-15.


Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009.

Bueid A, Howard SJ, Moore CB, Richardson MD, Harrison E, Bowyer P, Denning DW.

J Antimicrob Chemother. 2010 Oct;65(10):2116-8. doi: 10.1093/jac/dkq279. Epub 2010 Aug 20.


Isolation of multiple-triazole-resistant Aspergillus fumigatus strains carrying the TR/L98H mutations in the cyp51A gene in India.

Chowdhary A, Kathuria S, Randhawa HS, Gaur SN, Klaassen CH, Meis JF.

J Antimicrob Chemother. 2012 Feb;67(2):362-6. doi: 10.1093/jac/dkr443. Epub 2011 Oct 25.


Mutations in the cyp51A gene and susceptibility to itraconazole in Aspergillus fumigatus serially isolated from a patient with lung aspergilloma.

Chen J, Li H, Li R, Bu D, Wan Z.

J Antimicrob Chemother. 2005 Jan;55(1):31-7. Epub 2004 Nov 24.


Establishing in vitro-in vivo correlations for Aspergillus fumigatus: the challenge of azoles versus echinocandins.

Arendrup MC, Perkhofer S, Howard SJ, Garcia-Effron G, Vishukumar A, Perlin D, Lass-Flörl C.

Antimicrob Agents Chemother. 2008 Oct;52(10):3504-11. doi: 10.1128/AAC.00190-08. Epub 2008 Jul 21.


cyp51A-Based mechanisms of Aspergillus fumigatus azole drug resistance present in clinical samples from Germany.

Bader O, Weig M, Reichard U, Lugert R, Kuhns M, Christner M, Held J, Peter S, Schumacher U, Buchheidt D, Tintelnot K, Groß U; MykoLabNet-D Partners..

Antimicrob Agents Chemother. 2013 Aug;57(8):3513-7. doi: 10.1128/AAC.00167-13. Epub 2013 May 13.


Aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on Aspergillus fumigatus azole resistance.

Mortensen KL, Jensen RH, Johansen HK, Skov M, Pressler T, Howard SJ, Leatherbarrow H, Mellado E, Arendrup MC.

J Clin Microbiol. 2011 Jun;49(6):2243-51. doi: 10.1128/JCM.00213-11. Epub 2011 Apr 20.


Multiple cyp51A-based mechanisms identified in azole-resistant isolates of Aspergillus fumigatus from China.

Liu M, Zeng R, Zhang L, Li D, Lv G, Shen Y, Zheng H, Zhang Q, Zhao J, Zheng N, Liu W.

Antimicrob Agents Chemother. 2015 Jul;59(7):4321-5. doi: 10.1128/AAC.00003-15. Epub 2015 Apr 20.


Genotype-phenotype complexity of the TR46/Y121F/T289A cyp51A azole resistance mechanism in Aspergillus fumigatus.

Snelders E, Camps SM, Karawajczyk A, Rijs AJ, Zoll J, Verweij PE, Melchers WJ.

Fungal Genet Biol. 2015 Sep;82:129-35. doi: 10.1016/j.fgb.2015.06.001. Epub 2015 Jun 16.


Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene.

Lockhart SR, Frade JP, Etienne KA, Pfaller MA, Diekema DJ, Balajee SA.

Antimicrob Agents Chemother. 2011 Sep;55(9):4465-8. doi: 10.1128/AAC.00185-11. Epub 2011 Jun 20.


Three-dimensional models of 14α-sterol demethylase (Cyp51A) from Aspergillus lentulus and Aspergillus fumigatus: an insight into differences in voriconazole interaction.

Alcazar-Fuoli L, Cuesta I, Rodriguez-Tudela JL, Cuenca-Estrella M, Sanglard D, Mellado E.

Int J Antimicrob Agents. 2011 Nov;38(5):426-34. doi: 10.1016/j.ijantimicag.2011.06.005. Epub 2011 Aug 25.


Role of Aspergillus lentulus 14-α sterol demethylase (Cyp51A) in azole drug susceptibility.

Mellado E, Alcazar-Fuoli L, Cuenca-Estrella M, Rodriguez-Tudela JL.

Antimicrob Agents Chemother. 2011 Dec;55(12):5459-68. doi: 10.1128/AAC.05178-11. Epub 2011 Sep 26.


Mutations in the Cyp51A gene and susceptibility to itraconazole in Aspergillus fumigatus isolated from avian farms in France and China.

Wang DY, Gricourt M, Arné P, Thierry S, Seguin D, Chermette R, Huang WY, Dannaoui E, Botterel F, Guillot J.

Poult Sci. 2014 Jan;93(1):12-5. doi: 10.3382/ps.2013-03541.


Targeted gene disruption of the 14-alpha sterol demethylase (cyp51A) in Aspergillus fumigatus and its role in azole drug susceptibility.

Mellado E, Garcia-Effron G, Buitrago MJ, Alcazar-Fuoli L, Cuenca-Estrella M, Rodriguez-Tudela JL.

Antimicrob Agents Chemother. 2005 Jun;49(6):2536-8.


Epidemiological cutoffs and cross-resistance to azole drugs in Aspergillus fumigatus.

Rodriguez-Tudela JL, Alcazar-Fuoli L, Mellado E, Alastruey-Izquierdo A, Monzon A, Cuenca-Estrella M.

Antimicrob Agents Chemother. 2008 Jul;52(7):2468-72. doi: 10.1128/AAC.00156-08. Epub 2008 May 12.


Low prevalence of resistance to azoles in Aspergillus fumigatus in a French cohort of patients treated for haematological malignancies.

Alanio A, Sitterlé E, Liance M, Farrugia C, Foulet F, Botterel F, Hicheri Y, Cordonnier C, Costa JM, Bretagne S.

J Antimicrob Chemother. 2011 Feb;66(2):371-4. doi: 10.1093/jac/dkq450. Epub 2010 Dec 5.


Differences in interactions between azole drugs related to modifications in the 14-alpha sterol demethylase gene (cyp51A) of Aspergillus fumigatus.

Garcia-Effron G, Mellado E, Gomez-Lopez A, Alcazar-Fuoli L, Cuenca-Estrella M, Rodriguez-Tudela JL.

Antimicrob Agents Chemother. 2005 May;49(5):2119-21.


Epidemiological cutoff values for azoles and Aspergillus fumigatus based on a novel mathematical approach incorporating cyp51A sequence analysis.

Meletiadis J, Mavridou E, Melchers WJ, Mouton JW, Verweij PE.

Antimicrob Agents Chemother. 2012 May;56(5):2524-9. doi: 10.1128/AAC.05959-11. Epub 2012 Feb 13.


Azole preexposure affects the Aspergillus fumigatus population in patients.

Alanio A, Cabaret O, Sitterlé E, Costa JM, Brisse S, Cordonnier C, Bretagne S.

Antimicrob Agents Chemother. 2012 Sep;56(9):4948-50. doi: 10.1128/AAC.05990-11. Epub 2012 Jun 18.

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