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A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF).

Bai F, Asojo OA, Cirillo P, Ciustea M, Ledizet M, Aristoff PA, Leng L, Koski RA, Powell TJ, Bucala R, Anthony KG.

J Biol Chem. 2012 Aug 31;287(36):30653-63. doi: 10.1074/jbc.M112.385583. Epub 2012 Jul 10.


MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations.

Fan C, Rajasekaran D, Syed MA, Leng L, Loria JP, Bhandari V, Bucala R, Lolis EJ.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10994-9. doi: 10.1073/pnas.1221817110. Epub 2013 Jun 17.


An Analysis of MIF Structural Features that Control Functional Activation of CD74.

Pantouris G, Syed MA, Fan C, Rajasekaran D, Cho TY, Rosenberg EM Jr, Bucala R, Bhandari V, Lolis EJ.

Chem Biol. 2015 Sep 17;22(9):1197-205. doi: 10.1016/j.chembiol.2015.08.006. Epub 2015 Sep 10.


Macrophage migration inhibitory factor inhibits the migration of cartilage end plate-derived stem cells by reacting with CD74.

Xiong CJ, Huang B, Zhou Y, Cun YP, Liu LT, Wang J, Li CQ, Pan Y, Wang H.

PLoS One. 2012;7(8):e43984. doi: 10.1371/journal.pone.0043984. Epub 2012 Aug 27. Erratum in: PLoS One. 2012;7(11). doi:10.1371/annotation/a5edef40-e46d-4810-9008-dbda429ccc2c.


Migration inhibitory factor enhances inflammation via CD74 in cartilage end plates with Modic type 1 changes on MRI.

Xiong C, Huang B, Cun Y, Aghdasi BG, Zhou Y.

Clin Orthop Relat Res. 2014 Jun;472(6):1943-54. doi: 10.1007/s11999-014-3508-y. Epub 2014 Feb 26.


The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF).

Merk M, Zierow S, Leng L, Das R, Du X, Schulte W, Fan J, Lue H, Chen Y, Xiong H, Chagnon F, Bernhagen J, Lolis E, Mor G, Lesur O, Bucala R.

Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):E577-85. doi: 10.1073/pnas.1102941108. Epub 2011 Aug 4.


The tautomerase active site of macrophage migration inhibitory factor is a potential target for discovery of novel anti-inflammatory agents.

Lubetsky JB, Dios A, Han J, Aljabari B, Ruzsicska B, Mitchell R, Lolis E, Al-Abed Y.

J Biol Chem. 2002 Jul 12;277(28):24976-82. Epub 2002 May 7.


Inhibition of MIF bioactivity by rational design of pharmacological inhibitors of MIF tautomerase activity.

Dios A, Mitchell RA, Aljabari B, Lubetsky J, O'Connor K, Liao H, Senter PD, Manogue KR, Lolis E, Metz C, Bucala R, Callaway DJ, Al-Abed Y.

J Med Chem. 2002 Jun 6;45(12):2410-6.


Crystallographic and receptor binding characterization of Plasmodium falciparum macrophage migration inhibitory factor complexed to two potent inhibitors.

Pantouris G, Rajasekaran D, Garcia AB, Ruiz VG, Leng L, Jorgensen WL, Bucala R, Lolis EJ.

J Med Chem. 2014 Oct 23;57(20):8652-6. doi: 10.1021/jm501168q. Epub 2014 Oct 8.


Macrophage migration inhibitory factor confers resistance to senescence through CD74-dependent AMPK-FOXO3a signaling in mesenchymal stem cells.

Xia W, Zhang F, Xie C, Jiang M, Hou M.

Stem Cell Res Ther. 2015 Apr 22;6:82. doi: 10.1186/s13287-015-0076-3.


Structural and functional characterization of a secreted hookworm Macrophage Migration Inhibitory Factor (MIF) that interacts with the human MIF receptor CD74.

Cho Y, Jones BF, Vermeire JJ, Leng L, DiFedele L, Harrison LM, Xiong H, Kwong YK, Chen Y, Bucala R, Lolis E, Cappello M.

J Biol Chem. 2007 Aug 10;282(32):23447-56. Epub 2007 Jun 13.


MIF, CD74 and other partners in kidney disease: tales of a promiscuous couple.

Sanchez-Niño MD, Sanz AB, Ruiz-Andres O, Poveda J, Izquierdo MC, Selgas R, Egido J, Ortiz A.

Cytokine Growth Factor Rev. 2013 Feb;24(1):23-40. doi: 10.1016/j.cytogfr.2012.08.001. Epub 2012 Sep 7. Review.


Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action.

Ouertatani-Sakouhi H, El-Turk F, Fauvet B, Cho MK, Pinar Karpinar D, Le Roy D, Dewor M, Roger T, Bernhagen J, Calandra T, Zweckstetter M, Lashuel HA.

J Biol Chem. 2010 Aug 20;285(34):26581-98. doi: 10.1074/jbc.M110.113951. Epub 2010 Jun 1.


A Leishmania ortholog of macrophage migration inhibitory factor modulates host macrophage responses.

Kamir D, Zierow S, Leng L, Cho Y, Diaz Y, Griffith J, McDonald C, Merk M, Mitchell RA, Trent J, Chen Y, Kwong YK, Xiong H, Vermeire J, Cappello M, McMahon-Pratt D, Walker J, Bernhagen J, Lolis E, Bucala R.

J Immunol. 2008 Jun 15;180(12):8250-61.


CD74 and macrophage migration inhibitory factor as therapeutic targets in gastric cancer.

Zheng YX, Yang M, Rong TT, Yuan XL, Ma YH, Wang ZH, Shen LS, Cui L.

World J Gastroenterol. 2012 May 14;18(18):2253-61. doi: 10.3748/wjg.v18.i18.2253.


Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity.

Lubetsky JB, Swope M, Dealwis C, Blake P, Lolis E.

Biochemistry. 1999 Jun 1;38(22):7346-54.


MIF signal transduction initiated by binding to CD74.

Leng L, Metz CN, Fang Y, Xu J, Donnelly S, Baugh J, Delohery T, Chen Y, Mitchell RA, Bucala R.

J Exp Med. 2003 Jun 2;197(11):1467-76.

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