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Effect of hypoxia and dexamethasone on inflammation and ion transporter function in pulmonary cells.

Urner M, Herrmann IK, Booy C, Roth-Z' Graggen B, Maggiorini M, Beck-Schimmer B.

Clin Exp Immunol. 2012 Aug;169(2):119-28. doi: 10.1111/j.1365-2249.2012.04595.x.


Dexamethasone prevents transport inhibition by hypoxia in rat lung and alveolar epithelial cells by stimulating activity and expression of Na+-K+-ATPase and epithelial Na+ channels.

Güney S, Schuler A, Ott A, Höschele S, Zügel S, Baloglu E, Bärtsch P, Mairbäurl H.

Am J Physiol Lung Cell Mol Physiol. 2007 Nov;293(5):L1332-8.


[Effects of hypoxia on the expression of glucocorticoid receptor and the anti-inflammatory action of dexamethasone in human alveolar epithelial cells].

Huang Y, Ni N, Lu C, Duan Y.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013 Jan;29(1):39-41. Chinese.


Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury.

Goolaerts A, Pellan-Randrianarison N, Larghero J, Vanneaux V, Uzunhan Y, Gille T, Dard N, Planès C, Matthay MA, Clerici C.

Am J Physiol Lung Cell Mol Physiol. 2014 Jun 1;306(11):L975-85. doi: 10.1152/ajplung.00242.2013.


Beta2-adrenergic stimulation blunts inhibition of epithelial ion transport by hypoxia of rat alveolar epithelial cells.

Loeh B, Baloglu E, Ke A, Bärtsch P, Mairbäurl H.

Cell Physiol Biochem. 2010;25(1):123-34. doi: 10.1159/000272057.


Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta.

Dada LA, Chandel NS, Ridge KM, Pedemonte C, Bertorello AM, Sznajder JI.

J Clin Invest. 2003 Apr;111(7):1057-64.


Functional roles of tumor necrosis factor-alpha and interleukin 1-Beta in hypoxia and reoxygenation.

Merry HE, Phelan P, Doaks M, Zhao M, Mulligan MS.

Ann Thorac Surg. 2015 Apr;99(4):1200-5. doi: 10.1016/j.athoracsur.2014.11.042.


Hypoxia upregulates activity and expression of the glucose transporter GLUT1 in alveolar epithelial cells.

Ouiddir A, Planès C, Fernandes I, VanHesse A, Clerici C.

Am J Respir Cell Mol Biol. 1999 Dec;21(6):710-8.


Resolvin D1 stimulates alveolar fluid clearance through alveolar epithelial sodium channel, Na,K-ATPase via ALX/cAMP/PI3K pathway in lipopolysaccharide-induced acute lung injury.

Wang Q, Zheng X, Cheng Y, Zhang YL, Wen HX, Tao Z, Li H, Hao Y, Gao Y, Yang LM, Smith FG, Huang CJ, Jin SW.

J Immunol. 2014 Apr 15;192(8):3765-77. doi: 10.4049/jimmunol.1302421.


Modulation of alpha-ENaC and alpha1-Na+-K+-ATPase by cAMP and dexamethasone in alveolar epithelial cells.

Dagenais A, Denis C, Vives MF, Girouard S, Massé C, Nguyen T, Yamagata T, Grygorczyk C, Kothary R, Berthiaume Y.

Am J Physiol Lung Cell Mol Physiol. 2001 Jul;281(1):L217-30.


KGF prevents hyperoxia-induced reduction of active ion transport in alveolar epithelial cells.

Borok Z, Mihyu S, Fernandes VF, Zhang XL, Kim KJ, Lubman RL.

Am J Physiol. 1999 Jun;276(6 Pt 1):C1352-60.


Dexamethasone blocks the systemic inflammation of alveolar hypoxia at several sites in the inflammatory cascade.

Chao J, Viets Z, Donham P, Wood JG, Gonzalez NC.

Am J Physiol Heart Circ Physiol. 2012 Jul 15;303(2):H168-77. doi: 10.1152/ajpheart.00106.2012.


Impairment of cation transport in A549 cells and rat alveolar epithelial cells by hypoxia.

Mairbäurl H, Wodopia R, Eckes S, Schulz S, Bärtsch P.

Am J Physiol. 1997 Oct;273(4 Pt 1):L797-806.


The systemic inflammation of alveolar hypoxia is initiated by alveolar macrophage-borne mediator(s).

Chao J, Wood JG, Blanco VG, Gonzalez NC.

Am J Respir Cell Mol Biol. 2009 Nov;41(5):573-82. doi: 10.1165/rcmb.2008-0417OC.


Hypoxia reduces alveolar epithelial sodium and fluid transport in rats: reversal by beta-adrenergic agonist treatment.

Vivona ML, Matthay M, Chabaud MB, Friedlander G, Clerici C.

Am J Respir Cell Mol Biol. 2001 Nov;25(5):554-61.


Propofol attenuates hypoxia-induced apoptosis in alveolar epithelial type II cells through down-regulating hypoxia-inducible factor-1α.

He XY, Shi XY, Yuan HB, Xu HT, Li YK, Zou Z.

Injury. 2012 Mar;43(3):279-83. doi: 10.1016/j.injury.2011.05.037.


Monocyte chemoattractant protein-1 released from alveolar macrophages mediates the systemic inflammation of acute alveolar hypoxia.

Chao J, Donham P, van Rooijen N, Wood JG, Gonzalez NC.

Am J Respir Cell Mol Biol. 2011 Jul;45(1):53-61. doi: 10.1165/rcmb.2010-0264OC.


Differential effects of hypoxic stress in alveolar epithelial cells and microvascular endothelial cells.

Signorelli S, Jennings P, Leonard MO, Pfaller W.

Cell Physiol Biochem. 2010;25(1):135-44. doi: 10.1159/000272066.


Hypoxia regulates gene expression of alveolar epithelial transport proteins.

Clerici C, Matthay MA.

J Appl Physiol (1985). 2000 May;88(5):1890-6. Review.


Hypoxia-induced inhibition of epithelial Na(+) channels in the lung. Role of Nedd4-2 and the ubiquitin-proteasome pathway.

Gille T, Randrianarison-Pellan N, Goolaerts A, Dard N, Uzunhan Y, Ferrary E, Hummler E, Clerici C, Planès C.

Am J Respir Cell Mol Biol. 2014 Mar;50(3):526-37. doi: 10.1165/rcmb.2012-0518OC.


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