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Items: 1 to 20 of 122


Role of ER stress in ventricular contractile dysfunction in type 2 diabetes.

Takada A, Miki T, Kuno A, Kouzu H, Sunaga D, Itoh T, Tanno M, Yano T, Sato T, Ishikawa S, Miura T.

PLoS One. 2012;7(6):e39893. doi: 10.1371/journal.pone.0039893. Epub 2012 Jun 29.


Endoplasmic reticulum stress in diabetic hearts abolishes erythropoietin-induced myocardial protection by impairment of phospho-glycogen synthase kinase-3beta-mediated suppression of mitochondrial permeability transition.

Miki T, Miura T, Hotta H, Tanno M, Yano T, Sato T, Terashima Y, Takada A, Ishikawa S, Shimamoto K.

Diabetes. 2009 Dec;58(12):2863-72. doi: 10.2337/db09-0158. Epub 2009 Sep 15.


Transcoronary gene transfer of SERCA2a increases coronary blood flow and decreases cardiomyocyte size in a type 2 diabetic rat model.

Sakata S, Lebeche D, Sakata Y, Sakata N, Chemaly ER, Liang L, Nakajima-Takenaka C, Tsuji T, Konishi N, del Monte F, Hajjar RJ, Takaki M.

Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H1204-7. Epub 2006 Sep 29.


Mechanical and metabolic rescue in a type II diabetes model of cardiomyopathy by targeted gene transfer.

Sakata S, Lebeche D, Sakata Y, Sakata N, Chemaly ER, Liang LF, Padmanabhan P, Konishi N, Takaki M, del Monte F, Hajjar RJ.

Mol Ther. 2006 May;13(5):987-96. Epub 2006 Feb 24.


Overexpression of the sarcoplasmic reticulum Ca(2+)-ATPase improves myocardial contractility in diabetic cardiomyopathy.

Trost SU, Belke DD, Bluhm WF, Meyer M, Swanson E, Dillmann WH.

Diabetes. 2002 Apr;51(4):1166-71.


Diabetes and Age-Related Differences in Vascular Function of Renal Artery: Possible Involvement of Endoplasmic Reticulum Stress.

Matsumoto T, Watanabe S, Ando M, Yamada K, Iguchi M, Taguchi K, Kobayashi T.

Rejuvenation Res. 2016 Feb;19(1):41-52. doi: 10.1089/rej.2015.1662.


Excessive degradation of adenine nucleotides by up-regulated AMP deaminase underlies afterload-induced diastolic dysfunction in the type 2 diabetic heart.

Kouzu H, Miki T, Tanno M, Kuno A, Yano T, Itoh T, Sato T, Sunaga D, Murase H, Tobisawa T, Ogasawara M, Ishikawa S, Miura T.

J Mol Cell Cardiol. 2015 Mar;80:136-45. doi: 10.1016/j.yjmcc.2015.01.004. Epub 2015 Jan 16.


Potential role of BNIP3 in cardiac remodeling, myocardial stiffness, and endoplasmic reticulum: mitochondrial calcium homeostasis in diastolic and systolic heart failure.

Chaanine AH, Gordon RE, Kohlbrenner E, Benard L, Jeong D, Hajjar RJ.

Circ Heart Fail. 2013 May;6(3):572-83. doi: 10.1161/CIRCHEARTFAILURE.112.000200. Epub 2013 Mar 18.


Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data.

Fredersdorf S, Thumann C, Zimmermann WH, Vetter R, Graf T, Luchner A, Riegger GA, Schunkert H, Eschenhagen T, Weil J.

Cardiovasc Diabetol. 2012 May 23;11:57.


Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a.

Younce CW, Burmeister MA, Ayala JE.

Am J Physiol Cell Physiol. 2013 Mar;304(6):C508-18. doi: 10.1152/ajpcell.00248.2012. Epub 2013 Jan 9.


Left-ventricular diastolic dysfunction may be prevented by chronic treatment with PPAR-alpha or -gamma agonists in a type 2 diabetic animal model.

Kim SK, Zhao ZS, Lee YJ, Lee KE, Kang SM, Choi D, Lim SK, Chung N, Lee HC, Cha BS.

Diabetes Metab Res Rev. 2003 Nov-Dec;19(6):487-93.


Gene delivery of sarcoplasmic reticulum calcium ATPase inhibits ventricular remodeling in ischemic mitral regurgitation.

Beeri R, Chaput M, Guerrero JL, Kawase Y, Yosefy C, Abedat S, Karakikes I, Morel C, Tisosky A, Sullivan S, Handschumacher MD, Gilon D, Vlahakes GJ, Hajjar RJ, Levine RA.

Circ Heart Fail. 2010 Sep;3(5):627-34. doi: 10.1161/CIRCHEARTFAILURE.109.891184. Epub 2010 Jul 15.


Preserved postischemic heart function in sucrose-fed type 2 diabetic OLETF rats.

Chen H, Higashino H, Kamenov ZA, Azuma M, Lee WH, Yang XQ, Zhou DJ, Yuan WJ.

Life Sci. 2003 May 9;72(25):2839-51.


Attenuation of endoplasmic reticulum stress-related myocardial apoptosis by SERCA2a gene delivery in ischemic heart disease.

Xin W, Lu X, Li X, Niu K, Cai J.

Mol Med. 2011 Mar-Apr;17(3-4):201-10. doi: 10.2119/molmed.2010.00197. Epub 2010 Dec 8.


Insulin inhibits beta-adrenergic action in ischemic/reperfused heart: a novel mechanism of insulin in cardioprotection.

Yu QJ, Si R, Zhou N, Zhang HF, Guo WY, Wang HC, Gao F.

Apoptosis. 2008 Feb;13(2):305-17. doi: 10.1007/s10495-007-0169-2.


[Effects of sarcoplasmic reticulum Ca(2+)-ATPase gene transfer in a minipig model of chronic ischemic heart failure].

Xin W, Lu XC, Li XY, Niu K, Cai JM.

Zhonghua Xin Xue Guan Bing Za Zhi. 2011 Apr;39(4):336-42. doi: 10.3760/cma.j.issn.0253-3758.2011.04.012. Chinese.


Partial left ventricular unloading reverses contractile dysfunction and helps recover gene expressions in failing rat hearts.

Wang J, Marui A, Ikeda T, Komeda M.

Interact Cardiovasc Thorac Surg. 2008 Feb;7(1):27-31. Epub 2007 Nov 15.


Time course of changes in the expression of DHPR, RyR(2), and SERCA2 after myocardial infarction in the rat left ventricle.

Sallinen P, Mänttäri S, Leskinen H, Ilves M, Ruskoaho H, Saarela S.

Mol Cell Biochem. 2007 Sep;303(1-2):97-103. Epub 2007 May 22.


Type 2 diabetes induces subendocardium-predominant reduction in transient outward K+ current with downregulation of Kv4.2 and KChIP2.

Sato T, Kobayashi T, Kuno A, Miki T, Tanno M, Kouzu H, Itoh T, Ishikawa S, Kojima T, Miura T, Tohse N.

Am J Physiol Heart Circ Physiol. 2014 Apr 1;306(7):H1054-65. doi: 10.1152/ajpheart.00414.2013. Epub 2014 Jan 31.


Inhibition of DPP-4 reduces acute mortality after myocardial infarction with restoration of autophagic response in type 2 diabetic rats.

Murase H, Kuno A, Miki T, Tanno M, Yano T, Kouzu H, Ishikawa S, Tobisawa T, Ogasawara M, Nishizawa K, Miura T.

Cardiovasc Diabetol. 2015 Aug 11;14:103. doi: 10.1186/s12933-015-0264-6.

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