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SnoN suppresses maturation of chondrocytes by mediating signal cross-talk between transforming growth factor-β and bone morphogenetic protein pathways.

Kawamura I, Maeda S, Imamura K, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.

J Biol Chem. 2012 Aug 17;287(34):29101-13. doi: 10.1074/jbc.M112.349415.


5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes.

Zuscik MJ, Baden JF, Wu Q, Sheu TJ, Schwarz EM, Drissi H, O'Keefe RJ, Puzas JE, Rosier RN.

J Cell Biochem. 2004 May 15;92(2):316-31.


Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.

Li TF, Darowish M, Zuscik MJ, Chen D, Schwarz EM, Rosier RN, Drissi H, O'Keefe RJ.

J Bone Miner Res. 2006 Jan;21(1):4-16.


Localization of Smads, the TGF-beta family intracellular signaling components during endochondral ossification.

Sakou T, Onishi T, Yamamoto T, Nagamine T, Sampath Tk, Ten Dijke P.

J Bone Miner Res. 1999 Jul;14(7):1145-52.


Bone morphogenic protein (BMP) signaling up-regulates neutral sphingomyelinase 2 to suppress chondrocyte maturation via the Akt protein signaling pathway as a negative feedback mechanism.

Kakoi H, Maeda S, Shinohara N, Matsuyama K, Imamura K, Kawamura I, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S.

J Biol Chem. 2014 Mar 21;289(12):8135-50. doi: 10.1074/jbc.M113.509331.


Induction of high temperature requirement A1, a serine protease, by TGF-beta1 in articular chondrocytes of mouse models of OA.

Xu L, Golshirazian I, Asbury BJ, Li Y.

Histol Histopathol. 2014 May;29(5):609-18. doi: 10.14670/HH-29.10.609.


The crosstalk between transforming growth factor-β1 and delta like-1 mediates early chondrogenesis during embryonic endochondral ossification.

Taipaleenmäki H, Harkness L, Chen L, Larsen KH, Säämänen AM, Kassem M, Abdallah BM.

Stem Cells. 2012 Feb;30(2):304-13. doi: 10.1002/stem.792.


Transforming growth factor β1 inhibits bone morphogenic protein (BMP)-2 and BMP-7 signaling via upregulation of Ski-related novel protein N (SnoN): possible mechanism for the failure of BMP therapy?

Ehnert S, Zhao J, Pscherer S, Freude T, Dooley S, Kolk A, Stöckle U, Nussler AK, Hube R.

BMC Med. 2012 Sep 7;10:101. doi: 10.1186/1741-7015-10-101.


Regulation of α5 and αV Integrin Expression by GDF-5 and BMP-7 in Chondrocyte Differentiation and Osteoarthritis.

Garciadiego-Cázares D, Aguirre-Sánchez HI, Abarca-Buis RF, Kouri JB, Velasquillo C, Ibarra C.

PLoS One. 2015 May 26;10(5):e0127166. doi: 10.1371/journal.pone.0127166.


Endoglin differentially modulates antagonistic transforming growth factor-beta1 and BMP-7 signaling.

Scherner O, Meurer SK, Tihaa L, Gressner AM, Weiskirchen R.

J Biol Chem. 2007 May 11;282(19):13934-43.


Bone morphogenetic protein-7 inhibits proximal tubular epithelial cell Smad3 signaling via increased SnoN expression.

Luo DD, Phillips A, Fraser D.

Am J Pathol. 2010 Mar;176(3):1139-47. doi: 10.2353/ajpath.2010.090459.


Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells.

Maeda S, Hayashi M, Komiya S, Imamura T, Miyazono K.

EMBO J. 2004 Feb 11;23(3):552-63.


TGF-β is a potent inducer of Nerve Growth Factor in articular cartilage via the ALK5-Smad2/3 pathway. Potential role in OA related pain?

Blaney Davidson EN, van Caam AP, Vitters EL, Bennink MB, Thijssen E, van den Berg WB, Koenders MI, van Lent PL, van de Loo FA, van der Kraan PM.

Osteoarthritis Cartilage. 2015 Mar;23(3):478-86. doi: 10.1016/j.joca.2014.12.005.


The high affinity ALK1-ligand BMP9 induces a hypertrophy-like state in chondrocytes that is antagonized by TGFβ1.

van Caam A, Blaney Davidson E, Garcia de Vinuesa A, van Geffen E, van den Berg W, Goumans MJ, ten Dijke P, van der Kraan P.

Osteoarthritis Cartilage. 2015 Jun;23(6):985-95. doi: 10.1016/j.joca.2015.02.007.


Age-related alterations in TGF beta signaling as a causal factor of cartilage degeneration in osteoarthritis.

van der Kraan PM.

Biomed Mater Eng. 2014;24(1 Suppl):75-80. doi: 10.3233/BME-140976.


TGF-β1 as possible link between loss of bone mineral density and chronic inflammation.

Ehnert S, Baur J, Schmitt A, Neumaier M, Lucke M, Dooley S, Vester H, Wildemann B, Stöckle U, Nussler AK.

PLoS One. 2010 Nov 22;5(11):e14073. doi: 10.1371/journal.pone.0014073.

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