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miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity.

Allen RM, Marquart TJ, Albert CJ, Suchy FJ, Wang DQ, Ananthanarayanan M, Ford DA, Baldán A.

EMBO Mol Med. 2012 Sep;4(9):882-95. doi: 10.1002/emmm.201201228.


Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content.

Paulusma CC, de Waart DR, Kunne C, Mok KS, Elferink RP.

J Biol Chem. 2009 Apr 10;284(15):9947-54. doi: 10.1074/jbc.M808667200.


Defective canalicular transport and toxicity of dietary ursodeoxycholic acid in the abcb11-/- mouse: transport and gene expression studies.

Wang R, Liu L, Sheps JA, Forrest D, Hofmann AF, Hagey LR, Ling V.

Am J Physiol Gastrointest Liver Physiol. 2013 Aug 15;305(4):G286-94. doi: 10.1152/ajpgi.00082.2013.


Hepatic overexpression of murine Abcb11 increases hepatobiliary lipid secretion and reduces hepatic steatosis.

Figge A, Lammert F, Paigen B, Henkel A, Matern S, Korstanje R, Shneider BL, Chen F, Stoltenberg E, Spatz K, Hoda F, Cohen DE, Green RM.

J Biol Chem. 2004 Jan 23;279(4):2790-9.


MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis.

Najafi-Shoushtari SH, Kristo F, Li Y, Shioda T, Cohen DE, Gerszten RE, Näär AM.

Science. 2010 Jun 18;328(5985):1566-9. doi: 10.1126/science.1189123.


Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.

Groen A, Romero MR, Kunne C, Hoosdally SJ, Dixon PH, Wooding C, Williamson C, Seppen J, Van den Oever K, Mok KS, Paulusma CC, Linton KJ, Oude Elferink RP.

Gastroenterology. 2011 Nov;141(5):1927-37.e1-4. doi: 10.1053/j.gastro.2011.07.042.


Expression of liver plasma membrane transporters in gallstone-susceptible and gallstone-resistant mice.

Müller O, Schalla C, Scheibner J, Stange EF, Fuchs M.

Biochem J. 2002 Feb 1;361(Pt 3):673-9.


3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) induce hepatic expression of the phospholipid translocase mdr2 in rats.

Hooiveld GJ, Vos TA, Scheffer GL, Van Goor H, Koning H, Bloks V, Loot AE, Meijer DK, Jansen PL, Kuipers F, Müller M.

Gastroenterology. 1999 Sep;117(3):678-87.


Mice overexpressing hepatic Abcb11 rapidly develop cholesterol gallstones.

Henkel A, Wei Z, Cohen DE, Green RM.

Mamm Genome. 2005 Dec;16(12):903-8.


MicroRNAs as biomarkers of hepatotoxicity in a randomized placebo-controlled study of simvastatin and ubiquinol supplementation.

Pek SL, Tavintharan S, Woon K, Lin L, Ong CN, Lim SC, Sum CF.

Exp Biol Med (Maywood). 2016 Feb;241(3):317-30. doi: 10.1177/1535370215605588.


MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor.

de Aguiar Vallim TQ, Tarling EJ, Kim T, Civelek M, Baldán Á, Esau C, Edwards PA.

Circ Res. 2013 Jun 7;112(12):1602-12. doi: 10.1161/CIRCRESAHA.112.300648.


Novel non-coding RNA-based therapeutic approaches to prevent statin-induced liver damage.

Bang C, Thum T.

EMBO Mol Med. 2012 Sep;4(9):863-5. doi: 10.1002/emmm.201201565. No abstract available.


Hepatic secretion of phospholipid vesicles in the mouse critically depends on mdr2 or MDR3 P-glycoprotein expression. Visualization by electron microscopy.

Crawford AR, Smith AJ, Hatch VC, Oude Elferink RP, Borst P, Crawford JM.

J Clin Invest. 1997 Nov 15;100(10):2562-7.


Overexpression of mdr2 gene by peroxisome proliferators in the mouse liver.

Miranda S, Vollrath V, Wielandt AM, Loyola G, Bronfman M, Chianale J.

J Hepatol. 1997 Jun;26(6):1331-9.


Reduced biliary sterol output with no change in total faecal excretion in mice expressing a human apolipoprotein A-I variant.

Parolini C, Caligari S, Gilio D, Manzini S, Busnelli M, Montagnani M, Locatelli M, Diani E, Giavarini F, Caruso D, Roda E, Roda A, Sirtori CR, Chiesa G.

Liver Int. 2012 Oct;32(9):1363-71. doi: 10.1111/j.1478-3231.2012.02855.x.


Decreased Na+-dependent taurocholate uptake and low expression of the sinusoidal Na+-taurocholate cotransporting protein (Ntcp) in livers of mdr2 P-glycoprotein-deficient mice.

Koopen NR, Wolters H, Voshol P, Stieger B, Vonk RJ, Meier PJ, Kuipers F, Hagenbuch B.

J Hepatol. 1999 Jan;30(1):14-21.


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