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Items: 1 to 20 of 101

1.

Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain.

Bottiglieri T, Arning E, Wasek B, Nunbhakdi-Craig V, Sontag JM, Sontag E.

J Neurosci. 2012 Jul 4;32(27):9173-81. doi: 10.1523/JNEUROSCI.0125-12.2012.

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Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation.

Sontag E, Nunbhakdi-Craig V, Sontag JM, Diaz-Arrastia R, Ogris E, Dayal S, Lentz SR, Arning E, Bottiglieri T.

J Neurosci. 2007 Mar 14;27(11):2751-9.

4.

Folic Acid Reduces Tau Phosphorylation by Regulating PP2A Methylation in Streptozotocin-Induced Diabetic Mice.

Zheng M, Zou C, Li M, Huang G, Gao Y, Liu H.

Int J Mol Sci. 2017 Apr 19;18(4). pii: E861. doi: 10.3390/ijms18040861.

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Folic acid inhibits tau phosphorylation through regulation of PP2A methylation in SH-SY5Y cells.

Li W, Jiang M, Xiao Y, Zhang X, Cui S, Huang G.

J Nutr Health Aging. 2015 Feb;19(2):123-9. doi: 10.1007/s12603-014-0514-4.

PMID:
25651436
7.

Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.

Zhou XW, Gustafsson JA, Tanila H, Bjorkdahl C, Liu R, Winblad B, Pei JJ.

Neurobiol Dis. 2008 Sep;31(3):386-94. doi: 10.1016/j.nbd.2008.05.013. Epub 2008 Jul 23.

PMID:
18586097
8.
9.

Folate is related to phosphorylated neurofilament-H and P-tau (Ser396) in rat brain.

Obeid R, Schlundt J, Umanskaya N, Herrmann W, Herrmann M.

J Neurochem. 2011 Jun;117(6):1047-54. doi: 10.1111/j.1471-4159.2011.07280.x. Epub 2011 May 13.

10.

Morroniside-Induced PP2A Activation Antagonizes Tau Hyperphosphorylation in a Cellular Model of Neurodegeneration.

Yang CC, Kuai XX, Gao WB, Yu JC, Wang Q, Li L, Zhang L.

J Alzheimers Dis. 2016;51(1):33-44. doi: 10.3233/JAD-150728.

PMID:
26836014
11.

Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam.

Arif M, Kazim SF, Grundke-Iqbal I, Garruto RM, Iqbal K.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1144-9. doi: 10.1073/pnas.1322614111. Epub 2014 Jan 6.

12.

Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation.

Wang Y, Yang R, Gu J, Yin X, Jin N, Xie S, Wang Y, Chang H, Qian W, Shi J, Iqbal K, Gong CX, Cheng C, Liu F.

Neurobiol Aging. 2015 Jan;36(1):188-200. doi: 10.1016/j.neurobiolaging.2014.07.035. Epub 2014 Aug 1.

PMID:
25219467
13.

Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus.

Zhang CE, Tian Q, Wei W, Peng JH, Liu GP, Zhou XW, Wang Q, Wang DW, Wang JZ.

Neurobiol Aging. 2008 Nov;29(11):1654-65. Epub 2007 May 29.

PMID:
17537547
14.

Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation.

Xiong Y, Jing XP, Zhou XW, Wang XL, Yang Y, Sun XY, Qiu M, Cao FY, Lu YM, Liu R, Wang JZ.

Neurobiol Aging. 2013 Mar;34(3):745-56. doi: 10.1016/j.neurobiolaging.2012.07.003. Epub 2012 Aug 11.

PMID:
22892311
15.

B vitamin deficiency promotes tau phosphorylation through regulation of GSK3beta and PP2A.

Nicolia V, Fuso A, Cavallaro RA, Di Luzio A, Scarpa S.

J Alzheimers Dis. 2010;19(3):895-907. doi: 10.3233/JAD-2010-1284.

PMID:
20157245
16.

Methotrexate decreases PP2A methylation and increases tau phosphorylation in neuron.

Yoon SY, Choi HI, Choi JE, Sul CA, Choi JM, Kim DH.

Biochem Biophys Res Commun. 2007 Nov 23;363(3):811-6. Epub 2007 Sep 24.

PMID:
17904102
17.

Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice.

Sontag JM, Wasek B, Taleski G, Smith J, Arning E, Sontag E, Bottiglieri T.

Front Aging Neurosci. 2014 Aug 22;6:214. doi: 10.3389/fnagi.2014.00214. eCollection 2014.

18.

Protein Phosphatase 2A and Its Methylation Modulating Enzymes LCMT-1 and PME-1 Are Dysregulated in Tauopathies of Progressive Supranuclear Palsy and Alzheimer Disease.

Park HJ, Lee KW, Oh S, Yan R, Zhang J, Beach TG, Adler CH, Voronkov M, Braithwaite SP, Stock JB, Mouradian MM.

J Neuropathol Exp Neurol. 2018 Feb 1;77(2):139-148. doi: 10.1093/jnen/nlx110.

19.

GSK-3β is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner.

Chu D, Tan J, Xie S, Jin N, Yin X, Gong CX, Iqbal K, Liu F.

J Alzheimers Dis. 2016;49(2):365-75. doi: 10.3233/JAD-150497.

PMID:
26484916
20.

Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A.

Chasseigneaux S, Clamagirand C, Huguet L, Gorisse-Hussonnois L, Rose C, Allinquant B.

BMC Neurosci. 2014 Jun 30;15:82. doi: 10.1186/1471-2202-15-82.

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