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Items: 1 to 20 of 132

1.

Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha.

Yueh MF, Li T, Evans RM, Hammock B, Tukey RH.

PLoS One. 2012;7(6):e37705. doi: 10.1371/journal.pone.0037705. Epub 2012 Jun 15.

2.

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression.

Wang H, Faucette S, Sueyoshi T, Moore R, Ferguson S, Negishi M, LeCluyse EL.

J Biol Chem. 2003 Apr 18;278(16):14146-52. Epub 2003 Feb 5.

3.

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.

Wang H, Faucette S, Moore R, Sueyoshi T, Negishi M, LeCluyse E.

J Biol Chem. 2004 Jul 9;279(28):29295-301. Epub 2004 Apr 28.

4.

Gender matters: estrogen receptor alpha (ERα) and histone deacetylase (HDAC) 1 and 2 control the gender-specific transcriptional regulation of human uridine diphosphate glucuronosyltransferases genes (UGT1A).

Kalthoff S, Winkler A, Freiberg N, Manns MP, Strassburg CP.

J Hepatol. 2013 Oct;59(4):797-804. doi: 10.1016/j.jhep.2013.05.028. Epub 2013 May 25.

PMID:
23714156
5.

Estradiol induces cytochrome P450 2B6 expression at high concentrations: implication in estrogen-mediated gene regulation in pregnancy.

Koh KH, Jurkovic S, Yang K, Choi SY, Jung JW, Kim KP, Zhang W, Jeong H.

Biochem Pharmacol. 2012 Jul 1;84(1):93-103. doi: 10.1016/j.bcp.2012.03.016. Epub 2012 Mar 30.

6.

The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics.

Sugatani J, Yamakawa K, Tonda E, Nishitani S, Yoshinari K, Degawa M, Abe I, Noguchi H, Miwa M.

Biochem Pharmacol. 2004 Mar 1;67(5):989-1000. Erratum in: Biochem Pharmacol. 2004 Jun 15;67(12):2991-2.

PMID:
15104253
7.

Effects of triclocarban on the transcription of estrogen, androgen and aryl hydrocarbon receptor responsive genes in human breast cancer cells.

Tarnow P, Tralau T, Hunecke D, Luch A.

Toxicol In Vitro. 2013 Aug;27(5):1467-75. doi: 10.1016/j.tiv.2013.03.003. Epub 2013 Mar 21.

8.

Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor.

Choi E, Lee S, Yeom SY, Kim GH, Lee JW, Kim SW.

Mol Endocrinol. 2005 Jul;19(7):1711-9. Epub 2005 Mar 10.

PMID:
15764585
9.

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.

Rencurel F, Stenhouse A, Hawley SA, Friedberg T, Hardie DG, Sutherland C, Wolf CR.

J Biol Chem. 2005 Feb 11;280(6):4367-73. Epub 2004 Nov 29.

10.

Endosulfan induces CYP2B6 and CYP3A4 by activating the pregnane X receptor.

Casabar RC, Das PC, Dekrey GK, Gardiner CS, Cao Y, Rose RL, Wallace AD.

Toxicol Appl Pharmacol. 2010 Jun 15;245(3):335-43. doi: 10.1016/j.taap.2010.03.017. Epub 2010 Mar 31.

PMID:
20361990
11.

Differential activation of pregnane X receptor and constitutive androstane receptor by buprenorphine in primary human hepatocytes and HepG2 cells.

Li L, Hassan HE, Tolson AH, Ferguson SS, Eddington ND, Wang H.

J Pharmacol Exp Ther. 2010 Dec;335(3):562-71. doi: 10.1124/jpet.110.173187. Epub 2010 Sep 9.

12.

Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR).

Anderson LE, Dring AM, Hamel LD, Stoner MA.

Toxicol Lett. 2011 Apr 25;202(2):148-54. doi: 10.1016/j.toxlet.2011.02.004. Epub 2011 Feb 18.

13.

The role of constitutive androstane receptor in oxazaphosphorine-mediated induction of drug-metabolizing enzymes in human hepatocytes.

Wang D, Li L, Fuhrman J, Ferguson S, Wang H.

Pharm Res. 2011 Aug;28(8):2034-44. doi: 10.1007/s11095-011-0429-2. Epub 2011 Apr 13.

14.

The environmental estrogen, nonylphenol, activates the constitutive androstane receptor.

Hernandez JP, Huang W, Chapman LM, Chua S, Moore DD, Baldwin WS.

Toxicol Sci. 2007 Aug;98(2):416-26. Epub 2007 May 5.

15.
16.

Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes.

Sahi J, Shord SS, Lindley C, Ferguson S, LeCluyse EL.

J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):43-58. doi: 10.1002/jbt.20264.

PMID:
19202563
17.

Flame retardant BDE-47 effectively activates nuclear receptor CAR in human primary hepatocytes.

Sueyoshi T, Li L, Wang H, Moore R, Kodavanti PR, Lehmler HJ, Negishi M, Birnbaum LS.

Toxicol Sci. 2014 Feb;137(2):292-302. doi: 10.1093/toxsci/kft243. Epub 2013 Nov 11.

18.

Dehydroepiandrosterone induces human CYP2B6 through the constitutive androstane receptor.

Kohalmy K, Tamási V, Kóbori L, Sárváry E, Pascussi JM, Porrogi P, Rozman D, Prough RA, Meyer UA, Monostory K.

Drug Metab Dispos. 2007 Sep;35(9):1495-501. Epub 2007 Jun 25.

19.

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR.

Xie W, Barwick JL, Simon CM, Pierce AM, Safe S, Blumberg B, Guzelian PS, Evans RM.

Genes Dev. 2000 Dec 1;14(23):3014-23.

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