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Items: 1 to 20 of 135

1.

Occludin is a direct target of thyroid transcription factor-1 (TTF-1/NKX2-1).

Runkle EA, Rice SJ, Qi J, Masser D, Antonetti DA, Winslow MM, Mu D.

J Biol Chem. 2012 Aug 17;287(34):28790-801. doi: 10.1074/jbc.M112.367987. Epub 2012 Jul 2.

2.

The complexity of thyroid transcription factor 1 with both pro- and anti-oncogenic activities.

Mu D.

J Biol Chem. 2013 Aug 30;288(35):24992-5000. doi: 10.1074/jbc.R113.491647. Epub 2013 Jul 1. Review.

3.

Claudin-1 is a metastasis suppressor and correlates with clinical outcome in lung adenocarcinoma.

Chao YC, Pan SH, Yang SC, Yu SL, Che TF, Lin CW, Tsai MS, Chang GC, Wu CH, Wu YY, Lee YC, Hong TM, Yang PC.

Am J Respir Crit Care Med. 2009 Jan 15;179(2):123-33. doi: 10.1164/rccm.200803-456OC. Epub 2008 Sep 11.

PMID:
18787218
4.

Thyroid transcription factor-1 inhibits transforming growth factor-beta-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells.

Saito RA, Watabe T, Horiguchi K, Kohyama T, Saitoh M, Nagase T, Miyazono K.

Cancer Res. 2009 Apr 1;69(7):2783-91. doi: 10.1158/0008-5472.CAN-08-3490. Epub 2009 Mar 17.

5.

MicroRNA-33a mediates the regulation of high mobility group AT-hook 2 gene (HMGA2) by thyroid transcription factor 1 (TTF-1/NKX2-1).

Rice SJ, Lai SC, Wood LW, Helsley KR, Runkle EA, Winslow MM, Mu D.

J Biol Chem. 2013 Jun 7;288(23):16348-60. doi: 10.1074/jbc.M113.474643. Epub 2013 Apr 26.

6.

Thyroid transcription factor-1-regulated microRNA-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma cells.

Griesing S, Kajino T, Tai MC, Liu Z, Nakatochi M, Shimada Y, Suzuki M, Takahashi T.

Cancer Sci. 2017 Jul;108(7):1394-1404. doi: 10.1111/cas.13271. Epub 2017 Jun 10.

7.

Suppression of lung adenocarcinoma progression by Nkx2-1.

Winslow MM, Dayton TL, Verhaak RG, Kim-Kiselak C, Snyder EL, Feldser DM, Hubbard DD, DuPage MJ, Whittaker CA, Hoersch S, Yoon S, Crowley D, Bronson RT, Chiang DY, Meyerson M, Jacks T.

Nature. 2011 May 5;473(7345):101-4. doi: 10.1038/nature09881. Epub 2011 Apr 6.

8.

Inactivating mutations and hypermethylation of the NKX2-1/TTF-1 gene in non-terminal respiratory unit-type lung adenocarcinomas.

Matsubara D, Soda M, Yoshimoto T, Amano Y, Sakuma Y, Yamato A, Ueno T, Kojima S, Shibano T, Hosono Y, Kawazu M, Yamashita Y, Endo S, Hagiwara K, Fukayama M, Takahashi T, Mano H, Niki T.

Cancer Sci. 2017 Sep;108(9):1888-1896. doi: 10.1111/cas.13313. Epub 2017 Jul 29.

9.

Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis.

Li CM, Gocheva V, Oudin MJ, Bhutkar A, Wang SY, Date SR, Ng SR, Whittaker CA, Bronson RT, Snyder EL, Gertler FB, Jacks T.

Genes Dev. 2015 Sep 1;29(17):1850-62. doi: 10.1101/gad.267393.115.

10.

Thyroid transcription factor 1 represses the expression of Ki-67 and induces apoptosis in non-small cell lung cancer.

Zu YF, Wang XC, Chen Y, Wang JY, Liu X, Li X, Li CW, Xie YC, Luo Y, Shang XQ, Guo J.

Oncol Rep. 2012 Nov;28(5):1544-50. doi: 10.3892/or.2012.2009. Epub 2012 Aug 31.

11.

[Expression and clinical significance of the thyroid transcription factor 1 in Xuanwei lung adenocarcinoma].

Zu Y, Wang X, Liu X, Chen Y, Li C, Shang X, Xie Y, Zhao H, Wang J.

Zhongguo Fei Ai Za Zhi. 2013 Mar;16(3):131-7. doi: 10.3779/j.issn.1009-3419.2013.03.03. Chinese.

12.

Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells.

Shimobaba S, Taga S, Akizuki R, Hichino A, Endo S, Matsunaga T, Watanabe R, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.

Biochim Biophys Acta. 2016 Jun;1863(6 Pt A):1170-8. doi: 10.1016/j.bbamcr.2016.02.015. Epub 2016 Feb 24.

13.

Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung.

Maeda Y, Tsuchiya T, Hao H, Tompkins DH, Xu Y, Mucenski ML, Du L, Keiser AR, Fukazawa T, Naomoto Y, Nagayasu T, Whitsett JA.

J Clin Invest. 2012 Dec;122(12):4388-400. doi: 10.1172/JCI64048. Epub 2012 Nov 12.

14.

The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors.

Jonckheere N, Velghe A, Ducourouble MP, Copin MC, Renes IB, Van Seuningen I.

FEBS J. 2011 Jan;278(2):282-94. doi: 10.1111/j.1742-4658.2010.07945.x. Epub 2010 Dec 3.

15.

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.

Dey S, Sayers CM, Verginadis II, Lehman SL, Cheng Y, Cerniglia GJ, Tuttle SW, Feldman MD, Zhang PJ, Fuchs SY, Diehl JA, Koumenis C.

J Clin Invest. 2015 Jul 1;125(7):2592-608. doi: 10.1172/JCI78031. Epub 2015 May 26.

16.

Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1.

Tanaka H, Yanagisawa K, Shinjo K, Taguchi A, Maeno K, Tomida S, Shimada Y, Osada H, Kosaka T, Matsubara H, Mitsudomi T, Sekido Y, Tanimoto M, Yatabe Y, Takahashi T.

Cancer Res. 2007 Jul 1;67(13):6007-11.

17.

Hepatocyte nuclear factor 6 suppresses the migration and invasive growth of lung cancer cells through p53 and the inhibition of epithelial-mesenchymal transition.

Yuan XW, Wang DM, Hu Y, Tang YN, Shi WW, Guo XJ, Song JG.

J Biol Chem. 2013 Oct 25;288(43):31206-16. doi: 10.1074/jbc.M113.480285. Epub 2013 Sep 10.

18.

Obligate progression precedes lung adenocarcinoma dissemination.

Caswell DR, Chuang CH, Yang D, Chiou SH, Cheemalavagu S, Kim-Kiselak C, Connolly A, Winslow MM.

Cancer Discov. 2014 Jul;4(7):781-9. doi: 10.1158/2159-8290.CD-13-0862. Epub 2014 Apr 16.

19.

NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression.

Yamaguchi T, Hosono Y, Yanagisawa K, Takahashi T.

Cancer Cell. 2013 Jun 10;23(6):718-23. doi: 10.1016/j.ccr.2013.04.002. Review.

20.

Expression of thyroid transcription factor-1 in 16 human lung cancer cell lines.

Fujita J, Ohtsuki Y, Bandoh S, Ueda Y, Kubo A, Tojo Y, Yamaji Y, Ishida T.

Lung Cancer. 2003 Jan;39(1):31-6.

PMID:
12499091

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